KEGG   ENZYME: 2.6.1.105
Entry
EC 2.6.1.105                Enzyme                                 
Name
lysine---8-amino-7-oxononanoate transaminase;
DAPA aminotransferase (ambiguous);
bioA (gene name) (ambiguous);
bioK (gene name)
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
L-lysine:8-amino-7-oxononanoate aminotransferase
Reaction(IUBMB)
L-lysine + 8-amino-7-oxononanoate = (S)-2-amino-6-oxohexanoate + 7,8-diaminononanoate [RN:R10699]
Reaction(KEGG)
R10699
Substrate
L-lysine [CPD:C00047];
8-amino-7-oxononanoate [CPD:C01092]
Product
(S)-2-amino-6-oxohexanoate [CPD:C04076];
7,8-diaminononanoate [CPD:C01037]
Comment
A pyridoxal 5'-phosphate enzyme [2]. Participates in the pathway for biotin biosynthesis. The enzyme from the bacterium Bacillus subtilis cannot use S-adenosyl-L-methionine as amino donor and catalyses an alternative reaction for the conversion of 8-amino-7-oxononanoate to 7,8-diaminononanoate (cf. EC 2.6.1.62, adenosylmethionine---8-amino-7-oxononanoate transaminase).
History
EC 2.6.1.105 created 2014
Pathway
ec00780  Biotin metabolism
ec01100  Metabolic pathways
Orthology
K19563  lysine---8-amino-7-oxononanoate aminotransferase
Genes
BSUBSU30230(bioA)
BSRI33_3077(bioA)
BSLA7A1_1653
BSHBSU6051_30230(bioK)
BSYI653_14470
BSUTBSUB_03212(bioK)
BSULBSUA_03212(bioK)
BSUSQ433_16395
BSOBSNT_09443(bioA)
BSNBSn5_05955
BSQB657_30230(bioK)
BSXC663_2868(bioK)
BSPU712_15005
BSSBSUW23_14645(bioK)
BSTGYO_3271(bioA)
BLIBL00953(bioA)
BLDBLi00767(bioA)
BLHBaLi_c08650(bioA)
BAYRBAM_018280(bioA)
BAQBACAU_1786(bioA)
BYABANAU_1953(bioA)
BAMPB938_09455
BQYMUS_2182(bioA)
BAMLBAM5036_1765(bioK)
BAMARBAU_1803(bioK)
BAMNBASU_1783(bioK)
BAMBBAPNAU_1916(bioA)
BAMTAJ82_10385
BAMYV529_17980(bioA)
BMPNG74_01904(bioK)
BAOBAMF_1923(bioK)
BAZBAMTA208_07890(bioK)
BQLLL3_02013(bioK)
BXHBAXH7_01607(bioA)
BAMIKSO_010225
BAMCU471_18830
BAMFU722_09670
BSIACWD84_11855
BAEBATR1942_12905
BVMB9C48_09330
BSONS101395_00962(bioA)
BHTDIC78_16485
BMOJHC660_28870(bioK)
BIQAN935_15130
BJSMY9_3023
BACIB1NLA3E_02730
BACPSB24_00515
BACBOY17_12275
BACOOXB_3534
BACYQF06_13305
BACLBS34A_32870(bioA)
BALMBsLM_3007
BGYBGLY_0781(bioK)
BACSAUL54_01445
BITBIS30_04485
BACQDOE78_13825
BBADK7T73_02980(bioA)
BCABEFK13_15360(bioA)
BEOBEH_11235
BHABH0782
BKWBkAM31D_02745(bioK)
BGIBGM20_09065
BPFBpOF4_04195(bioA)
AFLAflv_1071(bioA)
AGNAFK25_09050
VIRX953_06770
VILCFK37_17920
VPNA21D_01032(bioK_1)
RUEDT065_18015
MSEMGMB29_11990(bioA)
CTHUHUR95_16680(bioA)
AACAaci_2857
SPOSDV702_05505
SPAEE2C16_12250(bioA)
LKILKI_05230
LECLGMK_07195
 » show all
Reference
1  [PMID:15880481]
  Authors
Van Arsdell SW, Perkins JB, Yocum RR, Luan L, Howitt CL, Chatterjee NP, Pero JG
  Title
Removing a bottleneck in the Bacillus subtilis biotin pathway: bioA utilizes lysine rather than S-adenosylmethionine as the amino donor in the KAPA-to-DAPA reaction.
  Journal
Biotechnol Bioeng 91:75-83 (2005)
DOI:10.1002/bit.20488
  Sequence
[bsu:BSU30230]
Reference
2  [PMID:20565114]
  Authors
Dey S, Lane JM, Lee RE, Rubin EJ, Sacchettini JC
  Title
Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase .
  Journal
Biochemistry 49:6746-60 (2010)
DOI:10.1021/bi902097j
  Sequence
[bsu:BSU30230]
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.105
IUBMB Enzyme Nomenclature: 2.6.1.105
ExPASy - ENZYME nomenclature database: 2.6.1.105
BRENDA, the Enzyme Database: 2.6.1.105
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