| Entry |
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| Name |
4-hydroxyglutamate transaminase;
4-hydroxyglutamate aminotransferase;
4-hydroxy-L-glutamate:2-oxoglutarate aminotransferase
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| Class |
Transferases;
Transferring nitrogenous groups;
Transaminases
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| Sysname |
erythro-4-hydroxy-L-glutamate:2-oxoglutarate aminotransferase
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| Reaction(IUBMB) |
erythro-4-hydroxy-L-glutamate + 2-oxoglutarate = (4R)-4-hydroxy-2-oxoglutarate + L-glutamate [RN: R05052]
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| Reaction(KEGG) |
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| Substrate |
erythro-4-hydroxy-L-glutamate [CPD: C05947];
2-oxoglutarate [CPD: C00026]
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| Product |
(4R)-4-hydroxy-2-oxoglutarate [CPD: C05946];
L-glutamate [CPD: C00025]
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| Comment |
The enzyme participates in a degradation pathway of trans-4-hydroxy-L-proline, a compound that contributes to the stability of the collagen triple helix. Oxaloacetate can replace 2-oxoglutarate. This enzyme may be identical with EC 2.6.1.1 aspartate transaminase.
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| History |
EC 2.6.1.23 created 1972, modified 1982, modified 2020
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| Pathway |
| ec00330 | Arginine and proline metabolism |
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| Reference |
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| Authors |
GOLDSTONE A, ADAMS E. |
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| Title |
Metabolism of gamma-hydroxyglutamic acid. I. Conversion to alpha-hydroxy-gamma-ketoglutarate by purified glutamic-aspartic transaminase to rat liver. |
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| Journal |
J Biol Chem 237:3476-85 (1962) |
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| Reference |
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| Authors |
KURATOMI K, FUKUNAGA K, KOBAYASHI Y. |
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| Title |
THE METABOLISM OF GAMMA-HYDROXYGLUTAMATE IN RAT LIVER. II. A TRANSAMINASE CONCERNED IN GAMMA-HYDROXYGLUTAMATE METABOLISM. |
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| Journal |
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| Reference |
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| Authors |
MAITRA U, DEEKKER E |
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| Title |
PURIFICATION OF RAT-LIVER GAMMA-HYDROXYGLUTAMATE TRANSAMINASE AND ITS PROBABLE IDENTITY WITH GLUTAMATE-ASPARTATE TRANSAMINASE. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.6.1.23 |
| ExPASy - ENZYME nomenclature database: | 2.6.1.23 |
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| LinkDB |
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