KEGG   ENZYME: 2.6.1.77Help
Entry
EC 2.6.1.77                 Enzyme                                 

Name
taurine---pyruvate aminotransferase;
Tpa
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
taurine:pyruvate aminotransferase
Reaction(IUBMB)
taurine + pyruvate = L-alanine + 2-sulfoacetaldehyde [RN:R05652]
Reaction(KEGG)
Substrate
taurine [CPD:C00245];
pyruvate [CPD:C00022]
Product
L-alanine [CPD:C00041];
2-sulfoacetaldehyde [CPD:C00593]
Comment
The enzyme from the bacterium Bilophila wadsworthia requires pyridoxal 5'-phosphate as a cofactor, and catalyses a reversible reaction that starts an anaerobic taurine degradation pathway. beta-Alanine is also a significant amino group donor. The enzyme from the bacterium Pseudomonas denitrificans PD1222 can also use hypotaurine, producing 2-sulfinoacetaldehyde, which spontaneously hydrolyses to sulfite and acetaldehyde. Unlike, EC 2.6.1.55, taurine---2-oxoglutarate transaminase, 2-oxoglutarate cannot serve as an acceptor for the amino group.
History
EC 2.6.1.77 created 2003
Pathway
ec00430  Taurine and hypotaurine metabolism
ec01100  Metabolic pathways
Orthology
K03851  taurine-pyruvate aminotransferase
Genes
VNA: PN96_16085
VEJ: VEJY3_24191
PGB: H744_1c1564
PCQ: PcP3B5_40420(tpa_3)
COLW: A3Q33_11510
PIN: Ping_0051
WOC: BA177_02200
GAI: IMCC3135_11690(tpa)
HHH: CLM76_04195
MPC: Mar181_2033
BPE: BP0721
BPC: BPTD_0724
BPER: BN118_0083
BPET: B1917_3102
BPEU: Q425_33090
BPAR: BN117_1002
BPA: BPP3675
BBR: BB4110
DVM: DvMF_0516
DDS: Ddes_0218
DWD: DSCW_03190(yhxA)
NEN: NCHU2750_31190(tpa)
MAQU: Maq22A_c21465(bioA)
SIL: SPO0673(tpa)
RUT: FIU92_02275(tpa1)
RSP: RSP_0943(yhxA)
RCP: RCAP_rcc02240(tpa)
RDE: RD1_0981(tpa)
RLI: RLO149_c001900(tpa)
PDE: Pden_4273
DSH: Dshi_2042(tpa)
KVL: KVU_0494(yhxA) KVU_0941(tpa)
KVU: EIO_1453
KRO: BVG79_01142(tpa)
PGA: PGA1_c28770(tpa)
PGL: PGA2_c26710(tpa)
PGD: Gal_00552
PHP: PhaeoP97_00629(tpa)
PPIC: PhaeoP14_02649(tpa)
OAT: OAN307_c06270(tpa)
OAR: OA238_c35800(tpa)
OTM: OSB_27890(tpa_2)
LAQU: R2C4_14985
PTP: RCA23_c01520(tpa)
CID: P73_3057
MALG: MALG_00569
RHC: RGUI_0795
SPSE: SULPSESMR1_03483(tpa)
RMM: ROSMUCSMR3_02376(tpa)
RID: RIdsm_05064(tpa_5)
ROH: FIU89_00700(tpa1)
ROT: FIV09_01645(tpa1)
GXL: H845_1617
TMO: TMO_c0442
BSR: I33_1053
BSL: A7A1_3801
BSH: BSU6051_09260(yhxA)
BSUT: BSUB_01021(yhxA)
BSUL: BSUA_01021(yhxA)
BSUS: Q433_05265
BSS: BSUW23_04675(yhxA)
BST: GYO_1214
BSO: BSNT_07358(yhxA)
BSQ: B657_09260(yhxA)
BSX: C663_0949(yhxA)
BAQ: BACAU_0912(yhxA)
BYA: BANAU_0857(yhxA)
BAMP: B938_04545
BAML: BAM5036_0854(yhxA)
BAMA: RBAU_0915(yhxA)
BAMN: BASU_0891(yhxA)
BAMB: BAPNAU_2850(yhxA)
BAMT: AJ82_05330
BAMY: V529_08870(yhxA)
BMP: NG74_00959(tpa_1)
BAO: BAMF_1022(yhxA)
BAZ: BAMTA208_04320(yhxA)
BQL: LL3_01007(yhxA)
BXH: BAXH7_00902(yhxA)
BQY: MUS_0963(yhxA)
BAMI: KSO_015115
BAMC: U471_09340
BAMF: U722_04800
BANS: BAPAT_1551
BCQ: BCQ_1668(bioA)
BCX: BCA_1667
BAL: BACI_c16570(bioA1)
BNC: BCN_1588
BCF: bcf_08105
BCER: BCK_00395
BTT: HD73_1844
BTHI: BTK_09360
BTG: BTB_c16490(yhxA)
BTI: BTG_12680
BTW: BF38_2830
BWW: bwei_1477(tpa) bwei_3380(tpa)
BPU: BPUM_0880
BPUM: BW16_04795
BPUS: UP12_04780
BMQ: BMQ_4417
BMD: BMD_4403
BMEG: BG04_1334
BAG: Bcoa_0555
BJS: MY9_1022
BMET: BMMGA3_06920(yhxA)
BACW: QR42_04590
BACP: SB24_05120
BACB: OY17_07440
BACY: QF06_03570
BACL: BS34A_10460(yhxA)
BALM: BsLM_0965
BGY: BGLY_1018
GGH: GHH_c13390(yhxA)
GEA: GARCT_01455(tpa)
ANM: GFC28_986
AAMY: GFC30_2204
ANL: GFC29_641
HLI: HLI_04685
VPN: A21D_02472(tpa)
PSYO: PB01_12610
PMS: KNP414_02471(yhxA)
PMW: B2K_13815
PSAB: PSAB_23050
PRI: PRIO_6435(yhxA)
PSWU: SY83_21850
AAC: Aaci_2668
AAD: TC41_2977
BTS: Btus_3087
SIV: SSIL_0757
STED: SPTER_40040(tpa)
 » show all
Taxonomy
Reference
1  [PMID:11082195]
  Authors
Laue H, Cook AM.
  Title
Biochemical and molecular characterization of taurine:pyruvate aminotransferase from the anaerobe Bilophila wadsworthia.
  Journal
Eur J Biochem 267:6841-8 (2000)
DOI:10.1046/j.1432-1033.2000.01782.x
  Sequence
Reference
2  [PMID:12471498]
  Authors
Cook AM, Denger K.
  Title
Dissimilation of the C2 sulfonates.
  Journal
Arch Microbiol 179:1-6 (2002)
DOI:10.1007/s00203-002-0497-0
Reference
3  [PMID:11728723]
  Authors
Masepohl B, Fuhrer F, Klipp W.
  Title
Genetic analysis of a Rhodobacter capsulatus gene region involved in utilization of taurine as a sulfur source.
  Journal
FEMS Microbiol Lett 205:105-11 (2001)
DOI:10.1111/j.1574-6968.2001.tb10932.x
Reference
4  [PMID:23603744]
  Authors
Felux AK, Denger K, Weiss M, Cook AM, Schleheck D
  Title
Paracoccus denitrificans PD1222 utilizes hypotaurine via transamination followed  by spontaneous desulfination to yield acetaldehyde and, finally, acetate for growth.
  Journal
J Bacteriol 195:2921-30 (2013)
DOI:10.1128/JB.00307-13
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.77
IUBMB Enzyme Nomenclature: 2.6.1.77
ExPASy - ENZYME nomenclature database: 2.6.1.77
BRENDA, the Enzyme Database: 2.6.1.77
CAS: 51901-18-9
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