| Entry |
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| Name |
O-ureido-L-serine synthase;
dcsD (gene name)
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| Class |
Transferases;
Transferring nitrogenous groups;
Transferring other nitrogenous groups
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| Sysname |
O-acetyl-L-serine:hydroxyurea 2-amino-2-carboxyethyltransferase
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| Reaction(IUBMB) |
O-acetyl-L-serine + hydroxyurea = O-ureido-L-serine + acetate [RN: R10461]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species. Also catalyses EC 2.5.1.47, cysteine synthase.
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| History |
EC 2.6.99.3 created 2013
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| Pathway |
| ec00997 | Biosynthesis of various secondary metabolites - part 3 |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K19725 | O-ureido-L-serine/cysteine synthase |
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| Reference |
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| Authors |
Kumagai T, Koyama Y, Oda K, Noda M, Matoba Y, Sugiyama M |
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| Title |
Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Uda N, Matoba Y, Kumagai T, Oda K, Noda M, Sugiyama M |
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| Title |
Establishment of an in vitro D-cycloserine-synthesizing system by using O-ureido-L-serine synthase and D-cycloserine synthetase found in the biosynthetic pathway. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.6.99.3 |
| ExPASy - ENZYME nomenclature database: | 2.6.99.3 |
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| LinkDB |
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