| Entry |
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| Name |
tetraacyldisaccharide 4'-kinase;
lipid-A 4'-kinase
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| Class |
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
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| Sysname |
ATP:2,2',3,3'-tetrakis[(3R)-3-hydroxytetradecanoyl]-beta-D-glucosaminyl-(1->6)-alpha-D-glucosaminyl-phosphate 4'-O-phosphotransferase
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| Reaction(IUBMB) |
ATP + {2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-beta-D-glucosaminyl}-(1->6)-{2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl phosphate} = ADP + {2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-4-O-phospho-beta-D-glucosaminyl}-(1->6)-{2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl phosphate} [RN: R04657]
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| Reaction(KEGG) |
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| Substrate |
ATP [CPD: C00002];
{2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-beta-D-glucosaminyl}-(1->6)-{2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl phosphate}
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| Product |
ADP [CPD: C00008];
{2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-4-O-phospho-beta-D-glucosaminyl}-(1->6)-{2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl phosphate}
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| Comment |
Involved with EC 2.3.1.129 (acyl-[acyl-carrier- protein]---UDP-N-acetylglucosamine O-acyltransferase) and EC 2.4.1.182 (lipid-A-disaccharide synthase) in the biosynthesis of the phosphorylated glycolipid, lipid A, in the outer membrane of Escherichia coli.
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| History |
EC 2.7.1.130 created 1990
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| Pathway |
| ec00540 | Lipopolysaccharide biosynthesis |
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| Orthology |
| K00912 | tetraacyldisaccharide 4'-kinase |
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| Genes |
» show all
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| Reference |
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| Authors |
Ray BL, Raetz CR. |
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| Title |
The biosynthesis of gram-negative endotoxin. A novel kinase in Escherichia coli membranes that incorporates the 4'-phosphate of lipid A. |
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| Journal |
J Biol Chem 262:1122-8 (1987) |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.7.1.130 |
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| LinkDB |
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