KEGG   ENZYME: 2.7.1.147
Entry
EC 2.7.1.147                Enzyme                                 

Name
ADP-specific glucose/glucosamine kinase;
ADP-specific glucokinase;
ADP-dependent glucokinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ADP:D-glucose/D-glucosamine 6-phosphotransferase
Reaction(IUBMB)
(1) ADP + D-glucose = AMP + D-glucose 6-phosphate [RN:R05804];
(2) ADP + D-glucosamine = AMP + D-glucosamine 6-phosphate [RN:R12594]
Reaction(KEGG)
Substrate
ADP [CPD:C00008];
D-glucose [CPD:C00031];
D-glucosamine [CPD:C00329]
Product
AMP [CPD:C00020];
D-glucose 6-phosphate [CPD:C00092];
D-glucosamine 6-phosphate [CPD:C00352]
Comment
Requires Mg2+. The enzyme, characterized from a number of hyperthermophilic archaeal species, is highly specific for ADP. No activity is detected when ADP is replaced by ATP, GDP, phosphoenolpyruvate, diphosphate or polyphosphate.
History
EC 2.7.1.147 created 2001, modified 2020
Pathway
ec00010  Glycolysis / Gluconeogenesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K00918  ADP-dependent phosphofructokinase/glucokinase
K08074  ADP-dependent glucokinase
Genes
HSA: 83440(ADPGK)
PTR: 748791(ADPGK)
PPS: 100988588(ADPGK)
GGO: 101140731(ADPGK)
PON: 100173850(ADPGK)
NLE: 100596634(ADPGK)
MCC: 699257(ADPGK)
MCF: 101866506(ADPGK)
CSAB: 103245364(ADPGK)
CATY: 105573490(ADPGK)
PANU: 101013948(ADPGK)
RRO: 104673839(ADPGK)
TFN: 117070396(ADPGK)
PTEH: 111526986(ADPGK)
CJC: 100385481(ADPGK)
SBQ: 101050870(ADPGK)
MMUR: 105873383(ADPGK)
MMU: 72141(Adpgk)
MCAL: 110301455(Adpgk)
MPAH: 110327365(Adpgk)
RNO: 315722(Adpgk)
MCOC: 116072504(Adpgk)
MUN: 110549574(Adpgk)
CGE: 100754978(Adpgk)
PLEU: 114708931(Adpgk)
NGI: 103736851(Adpgk)
HGL: 101717458(Adpgk)
CCAN: 109687654(Adpgk)
OCU: 100347024(ADPGK)
TUP: 102498911(ADPGK)
CFA: 478360(ADPGK)
VVP: 112935284(ADPGK)
VLG: 121482224(ADPGK)
AML: 100473629(ADPGK)
UMR: 103679135(ADPGK)
UAH: 113240943(ADPGK)
ORO: 101378614(ADPGK)
ELK: 111153171
MPUF: 101675628(ADPGK)
EJU: 114206550(ADPGK)
MLX: 118003689(ADPGK)
FCA: 101088581(ADPGK)
PTG: 102961110(ADPGK)
PPAD: 109262726(ADPGK)
AJU: 106974196(ADPGK)
HHV: 120235493(ADPGK)
BTA: 518158(ADPGK)
BOM: 102286604(ADPGK)
BIU: 109564750(ADPGK)
BBUB: 102410724(ADPGK)
CHX: 102181503(ADPGK)
OAS: 101116836(ADPGK)
ODA: 120853510(ADPGK)
SSC: 100623786(ADPGK)
CFR: 102523920(ADPGK)
CDK: 105087286(ADPGK)
BACU: 103021058(ADPGK)
LVE: 103082058(ADPGK)
OOR: 101278987(ADPGK)
DLE: 111177800(ADPGK)
PCAD: 102996053(ADPGK)
ECB: 100052166(ADPGK)
EPZ: 103555465(ADPGK)
EAI: 106836645(ADPGK)
MYB: 102260287(ADPGK)
MYD: 102775076(ADPGK)
MMYO: 118675492(ADPGK)
MNA: 107528420(ADPGK)
HAI: 109391764(ADPGK)
DRO: 112301941(ADPGK)
SHON: 118987779(ADPGK)
AJM: 119050113(ADPGK)
MMF: 118620149 118636169(ADPGK)
PALE: 102897483(ADPGK)
RAY: 107501104(ADPGK)
MJV: 108394720(ADPGK)
TOD: 119238824(ADPGK)
LAV: 100662497(ADPGK)
TMU: 101353805
MDO: 100016323(ADPGK)
SHR: 100921460(ADPGK)
PCW: 110213901(ADPGK)
OAA: 100077123(ADPGK)
GGA: 415317(ADPGK)
PCOC: 116244521(ADPGK)
MGP: 100544507(ADPGK)
CJO: 107318502(ADPGK)
NMEL: 110403602(ADPGK)
APLA: 101797470(ADPGK)
ACYG: 106044200(ADPGK)
TGU: 100230242(ADPGK)
LSR: 110483973(ADPGK)
SCAN: 103816150(ADPGK)
PMOA: 120508830(ADPGK)
GFR: 102040116(ADPGK)
FAB: 101814955(ADPGK)
PHI: 102108989(ADPGK)
PMAJ: 107209369(ADPGK)
CCAE: 111933914(ADPGK)
CCW: 104697511(ADPGK)
ETL: 114059930(ADPGK)
FPG: 101912436(ADPGK)
FCH: 102052366(ADPGK)
CLV: 102093047(ADPGK)
EGZ: 104130704(ADPGK)
NNI: 104016789(ADPGK)
ACUN: 113483794(ADPGK)
PADL: 103913426(ADPGK)
AAM: 106486110(ADPGK)
ASN: 102369271(ADPGK)
AMJ: 102576175(ADPGK)
CPOO: 109308846(ADPGK)
GGN: 109288341(ADPGK)
PSS: 102444452(ADPGK)
CMY: 102945709(ADPGK)
CPIC: 101937495(ADPGK)
TST: 117883709(ADPGK)
CABI: 116839428(ADPGK)
ACS: 100567625(adpgk)
PVT: 110084388(ADPGK)
PBI: 103059020(ADPGK)
PMUR: 107297693(ADPGK)
TSR: 106551694(ADPGK)
PGUT: 117674542(ADPGK)
ZVI: 118086453(ADPGK)
GJA: 107116940(ADPGK)
XLA: 108711296(adpgkl.L) 108716645(XB5992952.L) 108717798
XTR: 100216148 100489920(adpgkl) 100495684(adpgk)
NPR: 108784070(ADPGK) 108792739
DRE: 557919(adpgk) 566398(adpgk2)
IPU: 108269756 108275069(adpgk)
PHYP: 113529880(adpgk) 113538789
AMEX: 103040241 103047422(adpgk)
EEE: 113578613 113583561(adpgk)
TRU: 101076196(adpgk) 101076203
LCO: 104920148 104929546(adpgk)
ELY: 117260620(adpgk2) 117262464(adpgk)
PLEP: 121950689(adpgk) 121950805(adpgk2)
SLUC: 116060554(adpgk2) 116061969(adpgk)
ECRA: 117949226(adpgk) 117958519(adpgk2)
PFLV: 114554738 114560777(adpgk)
GAT: 120809336(adpgk) 120831602(adpgk2)
MSAM: 119890477(adpgk2) 119893196(adpgk)
CUD: 121513403(adpgk2) 121515601(adpgk)
ONL: 100698586(adpgk) 100699774
OAU: 116313276(adpgk2) 116330487(adpgk)
OLA: 101160066(adpgk) 101160396
OML: 112141254(adpgk) 112160421(adpgk2)
XMA: 102225042(adpgk) 102232621
XCO: 114143454 114153348(adpgk)
XHE: 116718732 116736635(adpgk)
PRET: 103461108(adpgk) 103462836
CVG: 107092158 107093211(adpgk)
CTUL: 119789620(adpgk2) 119793964(adpgk)
NFU: 107381177 107395420(adpgk)
KMR: 108237299(adpgk2) 108248323(adpgk)
ALIM: 106523670 106531205(adpgk)
AOCE: 111583744(adpgk) 111585860
CSEM: 103379410(adpgk) 103379918
POV: 109624554(adpgk) 109625024
LCF: 108877019 108883016(adpgk)
SDU: 111219002 111229922(adpgk)
SLAL: 111650379(adpgk) 111668843
XGL: 120793735(adpgk) 120795342(adpgk2)
BPEC: 110169162(adpgk) 110172923
MALB: 109954478 109974965(adpgk)
ELS: 105016080 105018670(adpgk)
SFM: 108923988 108942355(adpgk)
LOC: 102687542(adpgk) 102692797
LCM: 102354033 102364267(ADPGK)
CMK: 103178909 103188726(adpgk)
RTP: 109915605(adpgk)
DME: Dmel_CG6650(CG6650)
DER: 6545532
DSE: 6605634
DSI: Dsimw501_GD14473(Dsim_GD14473)
DAN: 6507219
DSR: 110190186
DPE: 6595753
DMN: 108153097
DWI: 6638735
DGR: 6556704
DAZ: 108613311
DNV: 108651233
DVI: 6622989
MDE: 101896047
LCQ: 111681213
ACOZ: 120950186
AARA: 120893506
AAG: 110676244
CPII: 120420919
AME: 413336
ACER: 107995904
BIM: 100749517
BTER: 100652288
CCAL: 108623529
OBB: 114877764
MGEN: 117229902
NMEA: 116434808
CGIG: 122397543
SOC: 105205417
MPHA: 105829982
AEC: 105145579
ACEP: 105620980
PBAR: 105429499
VEM: 105566163
HST: 105183903
DQU: 106741608
CFO: 105249194
FEX: 115234581
LHU: 105674879
PGC: 109855885
OBO: 105280856
PCF: 106792050
NVI: 100118248
CSOL: 105367804
MDL: 103576353
BMOR: 101746527
BMAN: 114244333
MSEX: 115450780
BANY: 112055004
PMAC: 106711958
PPOT: 106101577
PXU: 106113793
PRAP: 111001851
ZCE: 119832746
HAW: 110372149
BTAB: 109044175
CLEC: 106661214
NLU: 111052119
ZNE: 110841380
CSEC: 111866705
HAME: 121864507
DSV: 119463415
RSAN: 119401578
RMP: 119164142
VDE: 111243959
VJA: 111267421
TUT: 107361191
DPTE: 113796635
CSCU: 111624497
PTEP: 107447833
SDM: 118186328
CEL: CELE_C50D2.7(C50D2.7)
CBR: CBG06989
BMY: BM_BM2865(Bm2865)
TSP: Tsp_05422
BGT: 106074092
EGL: EGR_09230
NVE: 5506810
EPA: 110250152
ATEN: 116305926
ADF: 107332063
AMIL: 114973522
SPIS: 111320563
DGT: 114515678
DDI: DDB_G0287631(glk)
SPAR: SPRG_15821
LPIL: LIP_1249
MBAS: ALGA_3097
ASAC: ATHSA_0704
MJA: MJ_1604
MMP: MMP1296(pfkC)
MMD: GYY_07315
MMAK: MMKA1_15210(pfkC)
MMAO: MMOS7_14030(pfkC)
MMAD: MMJJ_15470
MAE: Maeo_0005
PHO: PH0589(PH0589) PH1645(PH1645)
TGA: TGAM_0818(glkA) TGAM_1465(pfkC)
MAC: MA_3562(glkA) MA_3563(pfk)
MTP: Mthe_1214
MCJ: MCON_0234(pfkC)
MBN: Mboo_1525
NMG: Nmag_3826
NCON: LC1Nh_0114
 » show all
Reference
1  [PMID:8530474]
  Authors
Kengen SW, Tuininga JE, de Bok FA, Stams AJ, de Vos WM.
  Title
Purification and characterization of a novel ADP-dependent glucokinase from the hyperthermophilic archaeon Pyrococcus furiosus.
  Journal
J Biol Chem 270:30453-7 (1995)
DOI:10.1074/jbc.270.51.30453
  Sequence
[pfu:PF0312]
Reference
2  [PMID:11098152]
  Authors
Koga S, Yoshioka I, Sakuraba H, Takahashi M, Sakasegawa S, Shimizu S, Ohshima T
  Title
Biochemical characterization, cloning, and sequencing of ADP-dependent (AMP-forming) glucokinase from two hyperthermophilic archaea, Pyrococcus furiosus and Thermococcus litoralis.
  Journal
J Biochem 128:1079-85 (2000)
DOI:10.1093/oxfordjournals.jbchem.a022836
Reference
3  [PMID:29146530]
  Authors
Aslam M, Takahashi N, Matsubara K, Imanaka T, Kanai T, Atomi H
  Title
Identification of the glucosamine kinase in the chitinolytic pathway of Thermococcus kodakarensis.
  Journal
J Biosci Bioeng 125:320-326 (2018)
DOI:10.1016/j.jbiosc.2017.10.005
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.147
IUBMB Enzyme Nomenclature: 2.7.1.147
ExPASy - ENZYME nomenclature database: 2.7.1.147
BRENDA, the Enzyme Database: 2.7.1.147
CAS: 173585-07-4
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