KEGG   ENZYME: 2.7.1.195Help
Entry
EC 2.7.1.195                Enzyme                                 

Name
protein-Npi-phosphohistidine---2-O-alpha-mannosyl-D-glycerate phosphotransferase;
mngA (gene names);
2-O-alpha-mannosyl-D-glycerate PTS permease;
EIIMngA;
Enzyme IIMngA;
Enzyme IIHrsA;
EIImannosylglycerate;
Frx
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
protein-Npi-phospho-L-histidine:2-O-alpha-mannopyranosyl-D-glycerate Npi-phosphotransferase
Reaction(IUBMB)
[protein]-Npi-phospho-L-histidine + 2-O-(alpha-D-mannopyranosyl)-D-glycerate [side 1] = [protein]-L-histidine + 2-O-(6-phospho-alpha-D-mannopyranosyl)-D-glycerate [side 2] [RN:R11169]
Reaction(KEGG)
Substrate
[protein]-Npi-phospho-L-histidine [CPD:C04261];
2-O-(alpha-D-mannopyranosyl)-D-glycerate[side 1] [CPD:C11544]
Product
[protein]-L-histidine [CPD:C00615];
2-O-(6-phospho-alpha-D-mannopyranosyl)-D-glycerate[side 2] [CPD:C16699]
Comment
This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it. The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9 (phosphoenolpyruvate---protein phosphotransferase). Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.
History
EC 2.7.1.195 created 1972 as EC 2.7.1.69, part transferred 2016 to EC 2.7.1.195
Orthology
K11200  2-O-A-mannosyl-D-glycerate PTS system EIIABC component
Genes
ECO: b0731(mngA)
ECJ: JW0720(mngA)
ECD: ECDH10B_0797(mngA)
EBW: BWG_0589(mngA)
ECOK: ECMDS42_0580(mngA)
EOI: ECO111_0747(mngA)
EOJ: ECO26_0791(mngA)
ESL: O3K_17990
ESO: O3O_07300
ESM: O3M_17970
ECK: EC55989_0714(mngA)
ELH: ETEC_0741
EUN: UMNK88_767(hrsA)
ENA: ECNA114_0666(mngA)
ECOS: EC958_0845
ECY: ECSE_0790
ECR: ECIAI1_0704(mngA)
EBR: ECB_00690(hrsA)
EBL: ECD_00690(mngA)
EBE: B21_00679(mngA)
EBD: ECBD_2930
ESE: ECSF_0663
EKF: KO11_20100(mngA)
EDJ: ECDH1ME8569_0689(mngA)
ELW: ECW_m0785(mngA)
ELL: WFL_03830(mngA)
ELP: P12B_c0701(mngA)
ECOJ: P423_03595
EFE: EFER_2373(mngA)
SBG: SBG_0634(mngA)
SBZ: A464_709
SFL: SF0566(hrsA)
SFX: S0579(hrsA)
SFE: SFxv_0624(mngA)
SFN: SFy_0752
SFS: SFyv_0793
SFT: NCTC1_00601(hrsA)
SSN: SSON_0682(hrsA)
SBO: SBO_0589(hrsA)
ENC: ECL_03001
ECLO: ENC_20070
ECLX: LI66_06280
ECLY: LI62_07180
EEC: EcWSU1_01279(hrsA)
EBG: FAI37_00135(mngA)
ESA: ESA_02617
CSK: ES15_2699(mngA)
CTU: CTU_13370(hrsA)
CKO: CKO_02414
EBF: D782_3124
VSP: VS_II0605
VCC: FAZ90_21110(mngA)
AVR: B565_2243
HLI: HLI_15290
LACK: FLP15_10585(mngA)
CDF: CD630_30860(mngA)
PDC: CDIF630_03369(mngA)
CDC: CD196_2878(hrsA)
CDL: CDR20291_2925(hrsA)
PDF: CD630DERM_30860(mngA)
ESX: ESOMN_v1c03240(mngA)
SMIR: SMM_0331
SMIA: P344_01970
SPRN: S100390_v1c09020(mngA)
SPIT: STU14_v1c09020(mngA)
 » show all
Taxonomy
Reference
1  [PMID:14645248]
  Authors
Sampaio MM, Chevance F, Dippel R, Eppler T, Schlegel A, Boos W, Lu YJ, Rock CO
  Title
Phosphotransferase-mediated transport of the osmolyte 2-O-alpha-mannosyl-D-glycerate in Escherichia coli occurs by the product of the mngA (hrsA) gene and is regulated by the mngR (farR) gene product acting as repressor.
  Journal
J Biol Chem 279:5537-48 (2004)
DOI:10.1074/jbc.M310980200
  Sequence
[eco:b0731]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.195
IUBMB Enzyme Nomenclature: 2.7.1.195
ExPASy - ENZYME nomenclature database: 2.7.1.195
BRENDA, the Enzyme Database: 2.7.1.195
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