KEGG   ENZYME: 2.7.1.226
Entry
EC 2.7.1.226                Enzyme                                 

Name
L-serine kinase (ADP);
serK (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ADP:L-serine 3-phosphotransferase
Reaction(IUBMB)
ADP + L-serine = AMP + O-phospho-L-serine [RN:R12342]
Reaction(KEGG)
R12342
Substrate
ADP [CPD:C00008];
L-serine [CPD:C00065]
Product
AMP [CPD:C00020];
O-phospho-L-serine [CPD:C01005]
Comment
The enzyme, characterized in the hyperthermophilic archaeon Thermococcus kodakarensis, participates in L-cysteine biosynthesis.
History
EC 2.7.1.226 created 2019
Pathway
ec00270  Cysteine and methionine metabolism
ec01100  Metabolic pathways
Orthology
K23370  L-serine kinase (ADP)
Genes
XBV: XBW1_4662
PRG: RB151_043990
SPSW: Sps_04804
LLO: LLO_2374
PPIC: PhaeoP14_00143
MTT: Ftrac_2662
PFU: PF0380
PFI: PFC_00865
PHO: PH0530(PH0530)
PAB: PAB1362
PYN: PNA2_1158
PYS: Py04_0575
TKO: TK0378
TON: TON_0620
TGA: TGAM_1907
TSI: TSIB_0895
THE: GQS_01905
THA: TAM4_25
THM: CL1_0055
TLT: OCC_10970
THS: TES1_0806
TNU: BD01_0459
TEU: TEU_09925
PPAC: PAP_07195
ACJ: ACAM_0517
SMR: Smar_0555
DKA: DKAM_0858
TAG: Tagg_1147
HBU: Hbut_1584
STO: STK_14020
MSE: Msed_2111
MCN: Mcup_0176
AHO: Ahos_0573
STEP: IC006_1932
PCL: Pcal_0721
ASC: ASAC_0963
BARB: AOA66_1092
CCAI: NAS2_1427
 » show all
Reference
1  [PMID:27857065]
  Authors
Makino Y, Sato T, Kawamura H, Hachisuka SI, Takeno R, Imanaka T, Atomi H
  Title
An archaeal ADP-dependent serine kinase involved in cysteine biosynthesis and serine metabolism.
  Journal
Nat Commun 7:13446 (2016)
DOI:10.1038/ncomms13446
  Sequence
[tko:TK0378]
Reference
2  [PMID:28358477]
  Authors
Nagata R, Fujihashi M, Kawamura H, Sato T, Fujita T, Atomi H, Miki K
  Title
Structural Study on the Reaction Mechanism of a Free Serine Kinase Involved in Cysteine Biosynthesis.
  Journal
ACS Chem Biol 12:1514-1523 (2017)
DOI:10.1021/acschembio.7b00064
  Sequence
[tko:TK0378]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.226
IUBMB Enzyme Nomenclature: 2.7.1.226
ExPASy - ENZYME nomenclature database: 2.7.1.226
BRENDA, the Enzyme Database: 2.7.1.226
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