KEGG   ENZYME: 2.7.11.2
Entry
EC 2.7.11.2                 Enzyme                                 

Name
[pyruvate dehydrogenase (acetyl-transferring)] kinase;
PDH kinase;
PDHK;
PDK;
PDK1;
PDK2;
PDK3;
PDK4;
pyruvate dehydrogenase kinase;
pyruvate dehydrogenase kinase (phosphorylating);
pyruvate dehydrogenase kinase activator protein;
STK1
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
Sysname
ATP:[pyruvate dehydrogenase (acetyl-transferring)] phosphotransferase
Reaction(IUBMB)
ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate [RN:R03449]
Reaction(KEGG)
R03449
Substrate
ATP [CPD:C00002];
[pyruvate dehydrogenase (acetyl-transferring)] [CPD:C01256]
Product
ADP [CPD:C00008];
[pyruvate dehydrogenase (acetyl-transferring)] phosphate [CPD:C01293]
Comment
The enzyme has no activating compound but is specific for its substrate. It is a mitochondrial enzyme associated with the pyruvate dehydrogenase complex in mammals. Phosphorylation inactivates EC 1.2.4.1, pyruvate dehydrogenase (acetyl-transferring).
History
EC 2.7.11.2 created 1978 as EC 2.7.1.99, transferred 2005 to EC 2.7.11.2
Orthology
K00898  pyruvate dehydrogenase kinase 2/3/4
K12077  pyruvate dehydrogenase kinase isoform 1
Genes
HSA: 5163(PDK1) 5164(PDK2) 5165(PDK3) 5166(PDK4)
PTR: 459743(PDK1) 468402(PDK2) 472448(PDK4) 740576(PDK3)
PPS: 100968174(PDK1) 100970620(PDK4) 100992308(PDK2) 100995647(PDK3)
GGO: 101129032(PDK2) 101143387(PDK3) 101149286(PDK4) 101150048(PDK1)
PON: 100174113(PDK2) 100435148(PDK4) 100442853(PDK1) 100462571(PDK3)
NLE: 100597085(PDK2) 100598085(PDK3) 100601990(PDK1) 100605243(PDK4)
MCC: 697772(PDK1) 698726(PDK4) 699394(PDK3) 704169(PDK2)
MCF: 101867293(PDK2) 102118837(PDK3) 102119067(PDK4) 102132161(PDK1)
CSAB: 103217325(PDK1) 103226523(PDK4) 103231727(PDK3) 103242950(PDK2)
RRO: 104654150(PDK3) 104656590(PDK4) 104673517(PDK1) 104680263(PDK2)
RBB: 108513535(PDK4) 108516442(PDK2) 108522274(PDK1) 108524111(PDK3)
CJC: 100386396(PDK2) 100388325(PDK3) 100402844(PDK1) 100407216(PDK4)
SBQ: 101037963(PDK1) 101038610(PDK3) 101048009(PDK2) 101049325(PDK4)
MMU: 18604(Pdk2) 228026(Pdk1) 236900(Pdk3) 27273(Pdk4)
MCAL: 110286641(Pdk3) 110296681(Pdk4) 110305050(Pdk2) 110312693(Pdk1)
MPAH: 110313531(Pdk3) 110317019(Pdk4) 110318417(Pdk1) 110331436(Pdk2)
RNO: 116551(Pdk1) 296849(Pdk3) 81530(Pdk2) 89813(Pdk4)
MUN: 110551207(Pdk2) 110559643(Pdk4) 110564184(Pdk3) 110565621(Pdk1)
CGE: 100751145 100758762(Pdk2) 100763413(Pdk4) 100770270(Pdk3) 100774056(Pdk1)
NGI: 103725230(Pdk4) 103725376(Pdk3) 103728651 103738377(Pdk2) 103751806(Pdk1)
HGL: 101698433(Pdk4) 101699582(Pdk3) 101699994(Pdk2) 101705587(Pdk1)
CCAN: 109691403(Pdk2) 109697144(Pdk3) 109699522(Pdk1) 109701002(Pdk4)
OCU: 100348343(PDK2) 100351323(PDK1) 100351580(PDK4) 100352037(PDK3)
TUP: 102468786(PDK4) 102469133(PDK2) 102483149(PDK3) 102499515(PDK1)
CFA: 476828(PDK1) 478801 480868(PDK3) 482310(PDK4) 491075(PDK2)
VVP: 112916403(PDK1) 112917852(PDK2) 112919100(PDK3) 112923906(PDK4)
AML: 100464908(PDK4) 100466029(PDK3) 100476739(PDK2) 100483652(PDK1)
UMR: 103658746(PDK4) 103659566(PDK1) 103660465(PDK2) 103668186(PDK3)
UAH: 113242221(PDK3) 113250772(PDK1) 113260367(PDK4) 113265612(PDK2)
ORO: 101362728(PDK3) 101367021(PDK2) 101370661(PDK4) 101383119(PDK1)
FCA: 101092256(PDK4) 101092705(PDK1) 101095314(PDK3) 101100013(PDK2)
PTG: 102948846(PDK3) 102951784 102960301(PDK1) 102963206(PDK2) 102969030(PDK4)
PPAD: 109247310(PDK2) 109249360(PDK3) 109263716(PDK4) 109273020(PDK1)
AJU: 106970005(PDK4) 106985184(PDK2) 106986815(PDK3) 106987925(PDK1)
BTA: 507367(PDK4) 510841(PDK3) 524075(PDK2) 528655(PDK1)
BOM: 102264999(PDK4) 102265648(PDK1) 102266253(PDK2) 102275065(PDK3)
BIU: 109555405(PDK3) 109558225(PDK4) 109566453(PDK1) 109573763(PDK2)
BBUB: 102390883(PDK2) 102394745(PDK3) 102413185(PDK4) 102416388(PDK1)
CHX: 102180838(PDK3) 102185217(PDK2) 102186251(PDK1) 102190015(PDK4)
OAS: 101108725(PDK3) 101108929(PDK2) 101113205(PDK1) 101117752(PDK4)
SSC: 100153858(PDK3) 100286778(PDK4) 100286871(PDK1) 100516037(PDK2)
CFR: 102508070(PDK2) 102511071(PDK3) 102518730(PDK4) 102518782(PDK1)
CDK: 105088722(PDK4) 105091095(PDK1) 105103897(PDK3) 105104826(PDK2)
BACU: 103000815(PDK4) 103007993 103016999(PDK1) 103018751(PDK2)
LVE: 103072788(PDK2) 103073094(PDK4) 103073975(PDK3) 103078387(PDK1)
OOR: 101271748(PDK1) 101279937(PDK2) 101286339(PDK4) 101288876(PDK3)
DLE: 111166477(PDK2) 111167510(PDK3) 111172870(PDK1) 111181307(PDK4)
PCAD: 102979242(PDK4) 102982880(PDK2) 102983475(PDK3) 102993902(PDK1)
ECB: 100052078(PDK4) 100060791(PDK3) 100064091(PDK1) 100147514(PDK2)
EPZ: 103543124 103551054(PDK2) 103553122(PDK1) 103555010(PDK4)
EAI: 106824116(PDK3) 106826450(PDK2) 106834715(PDK1) 106838924(PDK4)
MYB: 102251531(PDK4) 102255458(PDK3) 102259213(PDK2) 102262215(PDK1)
MYD: 102767099(PDK1) 102774306(PDK3) 102775297(PDK2) 102775518(PDK4)
MNA: 107531030(PDK1) 107534264(PDK3) 107539176(PDK2) 107541747(PDK4)
HAI: 109372242(PDK3) 109380767(PDK2) 109390399(PDK1) 109393138(PDK4)
DRO: 112305775(PDK1) 112313227(PDK3) 112316178(PDK2) 112319795(PDK4)
PALE: 102880150(PDK4) 102883688(PDK1) 102885302(PDK2) 102888523(PDK3)
RAY: 107498344(PDK3) 107503332(PDK4) 107505192(PDK1) 107517591(PDK2)
MJV: 108385121(PDK2) 108390609(PDK3) 108391482(PDK1) 108406227(PDK4)
LAV: 100655808(PDK1) 100670251 100671485(PDK3) 100674220(PDK4)
MDO: 100010271(PDK3) 100017644(PDK4) 100022514(PDK2) 100029831 100617164(PDK1)
SHR: 100924143(PDK2) 100924902(PDK3) 100932777(PDK1) 100934205(PDK4)
PCW: 110210803(PDK3) 110211577(PDK1) 110215793(PDK2) 110217579(PDK4)
OAA: 100084173(PDK1) 100088087(PDK4) 100090199(PDK2) 103170840(PDK3)
GGA: 107050147(PDKI2) 418595(PDK3) 420570(PDK4) 425972(PDK1)
MGP: 100540747(PDK4) 100551417(PDK1) 104915378
CJO: 107309122(PDK4) 107316706(PDK1) 107325193(PDK3) 107325226(PDK2)
NMEL: 110394291(PDK4) 110400361(PDK1) 110404303(PDK3)
APLA: 101790921(PDK1) 101793451(PDK3) 101796141(PDK4) 113840021(PDK2)
ACYG: 106029999(PDK1) 106037540(PDK4) 106037792(PDK3)
TGU: 100218846(PDK1) 100226102(PDK3) 100230570(PDK4) 116806667(PDK2)
LSR: 110474730(PDK4) 110474799(PDK2) 110482900(PDK1) 110483254(PDK3)
GFR: 102032982(PDK1) 102035869(PDK3) 102036508(PDK2) 102043114(PDK4)
FAB: 101810404(PDK4) 101812266(PDK2) 101812709(PDK1) 101819650(PDK3)
PHI: 102100647(PDK3) 102101703(PDK1) 102105276(PDK2) 102107706(PDK4)
PMAJ: 107198663(PDK2) 107200488(PDK4) 107204004(PDK3) 107207402(PDK1)
CCAE: 111922906(PDK3) 111924238(PDK4) 111932081(PDK1) 111940029
CCW: 104686204(PDK3) 104689332(PDK4) 104693871(PDK1)
ETL: 114054918(PDK1) 114057650(PDK3) 114069034(PDK2) 114072967(PDK4)
FPG: 101913912(PDK4) 101915736(PDK2) 101921375(PDK3) 101925003(PDK1)
FCH: 102050815(PDK1) 102050926(PDK3) 102054883(PDK4) 102055203(PDK2)
CLV: 102092387(PDK2) 102093738(PDK3) 102097281(PDK4) 102098636(PDK1)
EGZ: 104123442(PDK3) 104128057(PDK1) 104129066(PDK4)
NNI: 104010002(PDK1) 104012302(PDK2) 104012823(PDK4) 104022502(PDK3)
ACUN: 113477053(PDK4) 113479913(PDK3) 113482065(PDK1)
PADL: 103914484(PDK3) 103922372(PDK4) 103924235(PDK1)
AAM: 106483564(PDK4) 106492245(PDK3) 106492763(PDK2) 106499285(PDK1)
ASN: 102370160(PDK4) 102375213(PDK2) 102384931(PDK1) 102385909(PDK3)
AMJ: 102560712(PDK2) 102565725(PDK1) 102576429(PDK3) 106736620(PDK4)
PSS: 102454133(PDK2) 102458098(PDK4) 102458322(PDK3) 102462980(PDK1)
CMY: 102930569(PDK4) 102931646(PDK3) 102934483(PDK2) 102942305(PDK1)
CPIC: 101939116(PDK4) 101939432(PDK1) 101947440(PDK3) 101948702(PDK2)
ACS: 100555492(pdk1) 100560978(pdk4) 100562544(pdk3) 100565122(pdk2)
PVT: 110074717(PDK4) 110076723(PDK3) 110079134(PDK2) 110086017(PDK1)
PBI: 103048669(PDK2) 103052031(PDK4) 103052758(PDK1) 103063932(PDK3)
PMUR: 107282609(PDK2) 107283650(PDK4) 107291526(PDK1) 107298473(PDK3)
TSR: 106542459 106543989(PDK4) 106545023(PDK3) 106545193(PDK2)
PMUA: 114581688(PDK2) 114596206(PDK3) 114606930(PDK1) 114607069(PDK4)
GJA: 107107054(PDK1) 107112128 107112529(PDK2) 107114025(PDK3) 107118002(PDK4)
XLA: 108707984 108709313 379789(pdk4.L) 398840(pdk4.S) 432080(pdk1.L) 494745
XTR: 100135009(pdk3) 100497838(pdk1) 448511(pdk4)
NPR: 108790502(PDK4) 108790791(PDK3) 108800388(PDK1)
DRE: 393971(pdk2b) 555840(pdk1) 560068(pdk3a) 561007(pdk4) 794083(pdk2a)
MZE: 101472257 101479514(pdk3) 101482626(pdk1) 101483754(pdk4)
ONL: 100690776(pdk4) 100700648(pdk1) 100701650 100706734(pdk3)
OLA: 101155612(pdk4) 101161766(pdk1) 101171116(pdk3) 101175202
XMA: 102220162(pdk4) 102223173 102228650(pdk3) 102235390(pdk1)
XCO: 114136739(pdk3) 114148095(pdk1) 114152118 114156304(pdk4)
NFU: 107382959(pdk3) 107383300(pdk4) 107387611 107390016(pdk1)
LCF: 108877204(pdk4) 108888700(pdk1) 108892051 108902052(pdk3)
SDU: 111218429(pdk1) 111219703 111223416(pdk4) 111237227(pdk3)
LCM: 102347516(PDK2) 102354798(PDK3)
CMK: 103176918(pdk4) 103183848(pdk2) 103184837(pdk3)
BFO: 118403139
CIN: 100185085
APLC: 110977370
SKO: 100375387
DME: Dmel_CG8808(Pdk)
DER: 6541111
DSE: 6608352
DSI: Dsimw501_GD10655(Dsim_GD10655)
DAN: 6495314
DSR: 110177125
DPE: 6592195
DWI: 6640984
DAZ: 108615926
DNV: 108653823
DHE: 111604602
DVI: 6636500
MDE: 101896544
LCQ: 111688894
AAG: 5569118
PRAP: 110999946
HAW: 110379901
TNL: 113507471
API: 100166307
DNX: 107164354
AGS: 114131694
RMD: 113555897
CEL: CELE_ZK370.5(pdhk-2)
CBR: CBG06929(Cbr-pdhk-2)
BMY: Bm1_30205
CRG: 105337605
LAK: 106151501
SHX: MS3_10515
EGL: EGR_07392
NVE: 5514023
ADF: 107338823
AMIL: 114965217
PDAM: 113686862
DGT: 114519114
HMG: 100211141
ATH: AT3G06483(PDK)
ALY: 9320654
CRB: 17891628
CPAP: 110808360
CIT: 102615178
TCC: 18603766
DZI: 111306984
EGR: 104415295
CAM: 101496392(Pdk) 101500787
LJA: Lj0g3v0267349.1(Lj0g3v0267349.1) Lj4g3v2249050.1(Lj4g3v2249050.1) Lj6g3v1126390.1(Lj6g3v1126390.1)
FVE: 101310404
RCN: 112198319
PPER: 18792242
PMUM: 103323292
PAVI: 110763836
ZJU: 107433361
MCHA: 111009461
CMAX: 111479408
CMOS: 111457914
CPEP: 111791452
RCU: 8261345
JCU: 105643624
HBR: 110635268
MESC: 110611773
POP: 7496482
PEU: 105107180
INI: 109175738
SIND: 105156800
LSV: 111880400
CCAV: 112527429
BVG: 104889154
SOE: 110790972
DOSA: Os03t0370000-01(Os03g0370000) Os07t0637300-01(Os07g0637300)
ATS: 109735306(LOC109735306) 109769724(LOC109769724)
ZMA: 100193944 103638995 541677(pdlk1) 542603(pdlk2)
EGU: 105061503
DCT: 110099184
PEQ: 110037896
ATR: 18430097
APRO: F751_4520
SCE: YGL059W(PKP2) YIL042C(PKP1)
KMX: KLMA_10248(PKP2) KLMA_20512(PKP1) KLMA_40335
NCS: NCAS_0A13390(NCAS0A13390) NCAS_0D03210(NCAS0D03210)
NDI: NDAI_0A02650(NDAI0A02650) NDAI_0I01660(NDAI0I01660)
TPF: TPHA_0B02740(TPHA0B02740) TPHA_0J01760(TPHA0J01760)
TBL: TBLA_0B01550(TBLA0B01550) TBLA_0F02450(TBLA0F02450)
TDL: TDEL_0G03600(TDEL0G03600) TDEL_0H02230(TDEL0H02230)
KAF: KAFR_0A04690(KAFR0A04690) KAFR_0I01930(KAFR0I01930)
CAL: CAALFM_CR08860WA(PDK2)
SLB: AWJ20_2336(PKP2) AWJ20_864(PKP1)
NCR: NCU03796(stk-24) NCU06760(stk-48)
NTE: NEUTE1DRAFT111129(NEUTE1DRAFT_111129) NEUTE1DRAFT58210(NEUTE1DRAFT_58210)
MBE: MBM_04625
ANG: ANI_1_544024(An02g04000) ANI_1_682084(An09g05460)
PBN: PADG_07553 PADG_12250(PADG_07168)
PNO: SNOG_10913 SNOG_15668(SNOG_15666 SNOG_15667)
SPO: SPAC644.11c(pkp1)
TASA: A1Q1_01815
ABP: AGABI1DRAFT123518(AGABI1DRAFT_123518) AGABI1DRAFT72910(AGABI1DRAFT_72910)
ABV: AGABI2DRAFT179568(AGABI2DRAFT_179568) AGABI2DRAFT203285(AGABI2DRAFT_203285)
MGL: MGL_2833
MRT: MRET_3429
SMIN: v1.2.006537.t1(symbB.v1.2.006537.t1) v1.2.009791.t1(symbB.v1.2.009791.t1) v1.2.017212.t1(symbB.v1.2.017212.t1) v1.2.019767.t1(symbB.v1.2.019767.t1) v1.2.020323.t1(symbB.v1.2.020323.t1) v1.2.020323.t2(symbB.v1.2.020323.t2) v1.2.027845.t1(symbB.v1.2.027845.t1) v1.2.027845.t2(symbB.v1.2.027845.t2) v1.2.033580.t1(symbB.v1.2.033580.t1) v1.2.033580.t2(symbB.v1.2.033580.t2) v1.2.036480.t1(symbB.v1.2.036480.t1) v1.2.036764.t1(symbB.v1.2.036764.t1) v1.2.039627.t1(symbB.v1.2.039627.t1)
 » show all
Reference
1  [PMID:4401694]
  Authors
Linn TC, Pelley JW, Pettit FH, Hucho F, Randall DD, Reed LJ.
  Title
-Keto acid dehydrogenase complexes. XV. Purification and properties of the component enzymes of the pyruvate dehydrogenase complexes from bovine kidney and heart.
  Journal
Arch Biochem Biophys 148:327-42 (1972)
DOI:10.1016/0003-9861(72)90151-8
Reference
2  [PMID:3004826]
  Authors
Reed LJ, Damuni Z, Merryfield ML.
  Title
Regulation of mammalian pyruvate and branched-chain alpha-keto acid dehydrogenase complexes by phosphorylation-dephosphorylation.
  Journal
Curr Top Cell Regul 27:41-9 (1985)
DOI:10.1016/b978-0-12-152827-0.50011-6
Reference
3  [PMID:15629119]
  Authors
Tovar-Mendez A, Hirani TA, Miernyk JA, Randall DD.
  Title
Analysis of the catalytic mechanism of pyruvate dehydrogenase kinase.
  Journal
Arch Biochem Biophys 434:159-68 (2005)
DOI:10.1016/j.abb.2004.10.017
  Sequence
[ath:AT3G06483]
Reference
4  [PMID:15491151]
  Authors
Bao H, Kasten SA, Yan X, Hiromasa Y, Roche TE.
  Title
Pyruvate dehydrogenase kinase isoform 2 activity stimulated by speeding up the rate of dissociation of ADP.
  Journal
Biochemistry 43:13442-51 (2004)
DOI:10.1021/bi0494875
Reference
5  [PMID:12631265]
  Authors
Roche TE, Hiromasa Y, Turkan A, Gong X, Peng T, Yan X, Kasten SA, Bao H, Dong J.
  Title
Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1.
  Journal
Eur J Biochem 270:1050-6 (2003)
DOI:10.1046/j.1432-1033.2003.03468.x
Other DBs
ExplorEnz - The Enzyme Database: 2.7.11.2
IUBMB Enzyme Nomenclature: 2.7.11.2
ExPASy - ENZYME nomenclature database: 2.7.11.2
BRENDA, the Enzyme Database: 2.7.11.2
CAS: 9074-01-5
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