Entry |
|
Name |
mitogen-activated protein kinase kinase;
MAP kinase kinase;
MAP kinase kinase 4;
MAP kinase kinase 7;
MAP kinase or ERK kinase;
MAP2K;
MAPKK;
MAPKK1;
MEK;
MEK1;
MEK2;
MKK;
MKK2;
MKK4;
MKK6;
MKK7;
STK27
|
Class |
Transferases;
Transferring phosphorus-containing groups;
Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
|
Sysname |
ATP:protein phosphotransferase (MAPKKK-activated)
|
Reaction(IUBMB) |
ATP + a protein = ADP + a phosphoprotein [RN: R00162]
|
Reaction(KEGG) |
|
Substrate |
|
Product |
|
Comment |
This enzyme is a dual-specific protein kinase and requires mitogen-activated protein kinase kinase kinase (MAPKKK) for activation. It is required for activation of EC 2.7.11.24, mitogen-activated protein kinase. Phosphorylation of MEK1 by Raf involves phosphorylation of two serine residues [5]. Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumour necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischaemic injury.
|
History |
EC 2.7.12.2 created 2005
|
Orthology |
K04368 | mitogen-activated protein kinase kinase 1 |
K04369 | mitogen-activated protein kinase kinase 2 |
K04430 | mitogen-activated protein kinase kinase 4 |
K04431 | mitogen-activated protein kinase kinase 7 |
K04432 | mitogen-activated protein kinase kinase 3 |
K04433 | mitogen-activated protein kinase kinase 6 |
K04463 | mitogen-activated protein kinase kinase 5 |
K08294 | mitogen-activated protein kinase kinase |
K11226 | mitogen-activated protein kinase kinase |
K11227 | mitogen-activated protein kinase kinase |
K13413 | mitogen-activated protein kinase kinase 4/5 |
K19763 | dual specificity mitogen-activated protein kinase kinase JKK-1 |
K20602 | mitogen-activated protein kinase kinase 1 |
K20603 | mitogen-activated protein kinase kinase 2 |
K20604 | mitogen-activated protein kinase kinase 9 |
K20607 | mitogen-activated protein kinase kinase 3 |
|
Genes |
» show all
|
Reference |
|
Authors |
Mordret G. |
Title |
MAP kinase kinase: a node connecting multiple pathways. |
Journal |
|
Reference |
|
Authors |
Zheng CF, Guan KL. |
Title |
Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. |
Journal |
J Biol Chem 268:11435-9 (1993) |
Sequence |
|
Reference |
|
Authors |
Wu J, Harrison JK, Dent P, Lynch KR, Weber MJ, Sturgill TW. |
Title |
Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2. |
Journal |
|
Sequence |
|
Reference |
|
Authors |
Alessi DR, Saito Y, Campbell DG, Cohen P, Sithanandam G, Rapp U, Ashworth A, Marshall CJ, Cowley S |
Title |
Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1. |
Journal |
|
Sequence |
|
Reference |
|
Authors |
Pham CD, Arlinghaus RB, Zheng CF, Guan KL, Singh B. |
Title |
Characterization of MEK1 phosphorylation by the v-Mos protein. |
Journal |
Oncogene 10:1683-8 (1995) |
Reference |
|
Authors |
Han J, Lee JD, Jiang Y, Li Z, Feng L, Ulevitch RJ. |
Title |
Characterization of the structure and function of a novel MAP kinase kinase (MKK6). |
Journal |
|
Sequence |
|
Other DBs |
ExplorEnz - The Enzyme Database: | 2.7.12.2 |
ExPASy - ENZYME nomenclature database: | 2.7.12.2 |
|
LinkDB |
|