KEGG   ENZYME: 2.7.2.17
Entry
EC 2.7.2.17                 Enzyme                                 

Name
[amino-group carrier protein]-L-2-aminoadipate 6-kinase;
lysZ (gene name);
[amino group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine 5-O-kinase;
[amino group carrier protein]-L-2-aminoadipate 6-kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a carboxy group as acceptor
Sysname
[amino-group carrier protein]-C-terminal-[N-(1,4-dicarboxybutyl)-L-glutamine] 5-O-kinase
Reaction(IUBMB)
ATP + an [amino-group carrier protein]-C-terminal-[N-(1,4-dicarboxybutyl)-L-glutamine] = ADP + an [amino-group carrier protein]-C-terminal-{N-[1-carboxy-5-oxo-5-(phosphooxy)pentyl]-L-glutamine} [RN:R09776]
Reaction(KEGG)
R09776
Substrate
ATP [CPD:C00002];
[amino-group carrier protein]-C-terminal-[N-(1,4-dicarboxybutyl)-L-glutamine]
Product
ADP [CPD:C00008];
[amino-group carrier protein]-C-terminal-{N-[1-carboxy-5-oxo-5-(phosphooxy)pentyl]-L-glutamine}
Comment
The enzyme participates in an L-lysine biosynthetic pathway in certain species of bacteria and archaea.
History
EC 2.7.2.17 created 2020
Pathway
ec00300  Lysine biosynthesis
ec01100  Metabolic pathways
Orthology
K05828  [amino group carrier protein]-L-2-aminoadipate 6-kinase
Genes
MSD: MYSTI_01364
CCX: COCOR_02070(argB)
SGR: SGR_3480
SFA: Sfla_0119
STRP: F750_6905
SFI: SFUL_3352
SCZ: ABE83_19100
SCX: AS200_22015
SRW: TUE45_06898(argB_2)
SPAV: Spa2297_32270
SLAU: SLA_3043
SALJ: SMD11_6706(lysZ)
SESP: BN6_56680
PLK: CIK06_18390(argB)
CAI: Caci_6305
RCA: Rcas_3466
CAU: Caur_1087
CAG: Cagg_1877
HAU: Haur_3308
TRO: trd_1516(argB)
STI: Sthe_0218
ATM: ANT_12390(argB)
CAP: CLDAP_41070(argB)
DRA: DR_1420
DGE: Dgeo_0678
DEZ: DKM44_08260(argB)
DFC: DFI_07545
TRA: Trad_1399
TTH: TT_C1541
TTJ: TTHA1903
TSC: TSC_c01940(argB2)
TAQ: TO73_0100
MRB: Mrub_2721
TTR: Tter_0320
TAI: Taci_0449
TLI: Tlie_1471
MRO: MROS_0162
CABY: Cabys_3151
PTO: PTO1471
FAI: FAD_0506(lysZ)
CDIV: CPM_0547
PFU: PF1684
PFI: PFC_10185
PHO: PH1718(PH1718)
PAB: PAB0292(argB)
PYN: PNA2_0327
PYS: Py04_1634
TKO: TK0276
THS: TES1_0509
HHB: Hhub_3650(argB)
HALH: HTSR_0666(argB)
HHSR: HSR6_0692(argB)
HSU: HLASF_2139(argB)
HSF: HLASA_2173(argB)
HMA: rrnAC2676(argB2)
HHI: HAH_3081(argB2)
NPH: NP_5262A(argB)
NMO: Nmlp_1241(argB)
HUT: Huta_1500
HTI: HTIA_1541
HMU: Hmuk_0774
HALL: LC1Hm_3290(argB)
HARC: HARCEL1_01515(argB)
HWA: HQ_3716A(argB)
HWC: Hqrw_4131(argB)
HVO: HVO_0044(argB)
HME: HFX_0044(argB)
HLA: Hlac_2614
HDF: AArcSl_0041(argB)
HTU: Htur_0326
NMG: Nmag_1759(argB)
NAT: NJ7G_0261
SALI: L593_07895
APE: APE_1461.1(lysZ)
ACJ: ACAM_0920(lysZ)
IHO: Igni_0621
IIS: EYM_06110
IAG: Igag_1755
STO: STK_01940(argB_lysZ)
SSO: SSO0156(argB)
SOL: Ssol_1134
SSOA: SULA_1170
SSOL: SULB_1171
SSOF: SULC_1169
SAI: Saci_0751
SID: M164_1989
SII: LD85_2244
SIH: SiH_1927
SIR: SiRe_1854
SIC: SiL_1836
MSE: Msed_0165
MCN: Mcup_1908
AHO: Ahos_0884
STEP: IC006_1903
PAI: PAE2882
PIS: Pisl_0277
PCL: Pcal_0372
PAS: Pars_0967
PYR: P186_1635
POG: Pogu_1379
TNE: Tneu_1836
CMA: Cmaq_1300
TTN: TTX_0121(lysZ_argB)
TUZ: TUZN_1286
VDI: Vdis_0202
VMO: VMUT_1540
NMR: Nmar_1290
NID: NPIRD3C_0834(argB)
NIN: NADRNF5_0666(argB)
NCL: C5F47_06950(argB)
NOX: C5F49_06960(argB)
NUE: C5F50_09715(argB)
NCT: NMSP_0398(argB)
NGA: Ngar_c29950(argB)
NVN: NVIE_1688(argB)
NEV: NTE_00735
TAA: NMY3_02223(argB)
NFN: NFRAN_2985(lysZ)
NCV: NCAV_1250(lysZ)
NBV: T478_1045(argB)
NDV: NDEV_1625(argB)
KCR: Kcr_0810
BARB: AOA66_0021(argB)
CCAI: NAS2_0268
 » show all
Reference
1  [PMID:10613839]
  Authors
Nishida H, Nishiyama M, Kobashi N, Kosuge T, Hoshino T, Yamane H.
  Title
A prokaryotic gene cluster involved in synthesis of lysine through the amino adipate pathway: a key to the evolution of amino acid biosynthesis.
  Journal
Genome Res 9:1175-83 (1999)
DOI:10.1101/gr.9.12.1175
Reference
2  [PMID:19620981]
  Authors
Horie A, Tomita T, Saiki A, Kono H, Taka H, Mineki R, Fujimura T, Nishiyama C, Kuzuyama T, Nishiyama M
  Title
Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus.
  Journal
Nat Chem Biol 5:673-9 (2009)
DOI:10.1038/nchembio.198
  Sequence
[tth:TT_C1541]
Reference
3  [PMID:23434852]
  Authors
Ouchi T, Tomita T, Horie A, Yoshida A, Takahashi K, Nishida H, Lassak K, Taka H, Mineki R, Fujimura T, Kosono S, Nishiyama C, Masui R, Kuramitsu S, Albers SV, Kuzuyama T, Nishiyama M
  Title
Lysine and arginine biosyntheses mediated by a common carrier protein in Sulfolobus.
  Journal
Nat Chem Biol 9:277-83 (2013)
DOI:10.1038/nchembio.1200
  Sequence
[sai:Saci_0751]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.2.17
IUBMB Enzyme Nomenclature: 2.7.2.17
ExPASy - ENZYME nomenclature database: 2.7.2.17
BRENDA, the Enzyme Database: 2.7.2.17
LinkDB

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