Entry |
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Name |
glycerol-3-phosphate cytidylyltransferase;
CDP-glycerol pyrophosphorylase;
cytidine diphosphoglycerol pyrophosphorylase;
cytidine diphosphate glycerol pyrophosphorylase;
CTP:glycerol 3-phosphate cytidylyltransferase;
Gro-PCT;
tagD (gene name);
tarD (gene name)
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Class |
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
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Sysname |
CTP:sn-glycerol-3-phosphate cytidylyltransferase
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Reaction(IUBMB) |
CTP + sn-glycerol 3-phosphate = diphosphate + CDP-glycerol [RN: R00856]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
Involved in the biosynthesis of teichoic acid linkage units in bacterial cell walls.
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History |
EC 2.7.7.39 created 1972
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Pathway |
ec00564 | Glycerophospholipid metabolism |
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Orthology |
K00980 | glycerol-3-phosphate cytidylyltransferase |
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Genes |
» show all
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Reference |
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Authors |
SHAW DR. |
Title |
Pyrophosphorolysis and enzymic synthesis of cytidine diphosphate glycerol and cytidine diphosphate ribitol. |
Journal |
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Reference |
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Authors |
Park YS, Sweitzer TD, Dixon JE, Kent C |
Title |
Expression, purification, and characterization of CTP:glycerol-3-phosphate cytidylyltransferase from Bacillus subtilis. |
Journal |
J Biol Chem 268:16648-54 (1993) |
Reference |
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Authors |
Sanker S, Campbell HA, Kent C |
Title |
Negative cooperativity of substrate binding but not enzyme activity in wild-type and mutant forms of CTP:glycerol-3-phosphate cytidylyltransferase. |
Journal |
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Reference |
|
Authors |
Badurina DS, Zolli-Juran M, Brown ED |
Title |
CTP:glycerol 3-phosphate cytidylyltransferase (TarD) from Staphylococcus aureus catalyzes the cytidylyl transfer via an ordered Bi-Bi reaction mechanism with micromolar K(m) values. |
Journal |
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Sequence |
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Reference |
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Authors |
Pattridge KA, Weber CH, Friesen JA, Sanker S, Kent C, Ludwig ML |
Title |
Glycerol-3-phosphate cytidylyltransferase. Structural changes induced by binding of CDP-glycerol and the role of lysine residues in catalysis. |
Journal |
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Sequence |
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Other DBs |
ExplorEnz - The Enzyme Database: | 2.7.7.39 |
ExPASy - ENZYME nomenclature database: | 2.7.7.39 |
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LinkDB |
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