Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy

GTP:mRNA guanylyltransferase

GTP + (5')ppPur-mRNA = diphosphate + G(5')pppPur-mRNA [RN:R03828]

R03828
Reaction

GTP [CPD:C00044];
(5')ppPur-mRNA [CPD:C02100]

The enzyme can also modify synthetic poly(A) and poly(G) to form the structures m7G(5')pppAn and m7G(5')pppGn.

EC 2.7.7.50 created 1981

1  [PMID:1058472]

Ensinger MJ, Martin SA, Paoletti E, Moss B.

Modification of the 5'-terminus of mRNA by soluble guanylyl and methyl transferases from vaccinia virus.

Proc Natl Acad Sci U S A 72:2525-9 (1975)
DOI:10.1073/pnas.72.7.2525

2  [PMID:629955]

Groner Y, Gilboa E, Aviv H.

Methylation and capping of RNA polymerase II primary transcripts by HeLa nuclear homogenates.

Biochemistry 17:977-82 (1978)
DOI:10.1021/bi00599a005

3  [PMID:3029058]

Itoh N, Yamada H, Kaziro Y, Mizumoto K.

Messenger RNA guanylyltransferase from Saccharomyces cerevisiae. Large scale purification, subunit functions, and subcellular localization.

J Biol Chem 262:1989-95 (1987)

[sce:YGL130W]

4  [PMID:1194287]

Martin SA, Moss B.

Modification of RNA by mRNA guanylyltransferase and mRNA (guanine-7-)methyltransferase from vaccinia virions.

J Biol Chem 250:9330-5 (1975)

5  [PMID:1194286]

Martin SA, Paoletti E, Moss B.

Purification of mRNA guanylyltransferase and mRNA (guanine-7-) methyltransferase from vaccinia virions.

J Biol Chem 250:9322-9 (1975)