Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy

2'-(5-triphosphoribosyl)-3'-dephospho-CoA:apo-malonate-decarboxylase 2'-(5-phosphoribosyl)-3'-dephospho-CoA-transferase

2'-(5-triphosphoribosyl)-3'-dephospho-CoA + malonate decarboxylase apo-[acyl-carrier protein] = malonate decarboxylase holo-[acyl-carrier protein] + diphosphate [RN:R10706]

R10706
Reaction

2'-(5-triphosphoribosyl)-3'-dephospho-CoA [CPD:C19771];
malonate decarboxylase apo-[acyl-carrier protein]

The delta subunit of malonate decarboxylase serves as an an acyl-carrier protein (ACP) and contains the prosthetic group 2-(5-triphosphoribosyl)-3-dephospho-CoA. Two reactions are involved in the production of the holo-ACP form of this enzyme. The first reaction is catalysed by EC 2.4.2.52, triphosphoribosyl-dephospho-CoA synthase. The resulting prosthetic group is then attached to the ACP subunit via a phosphodiester linkage to a serine residue, thus forming the holo form of the enzyme, in a manner analogous to that of EC 2.7.7.61, citrate lyase holo-[acyl-carrier protein] synthase.

EC 2.7.7.66 created 2008

1  [PMID:11052675]

Hoenke S, Wild MR, Dimroth P

Biosynthesis of triphosphoribosyl-dephospho-coenzyme A, the precursor of the prosthetic group of malonate decarboxylase.

Biochemistry 39:13223-32 (2000)
DOI:10.1021/bi0011532

[kpn:KPN_01559]

2  [PMID:11052676]

Hoenke S, Schmid M, Dimroth P.

Identification of the active site of phosphoribosyl-dephospho-coenzyme A transferase and relationship of the enzyme to an ancient class of nucleotidyltransferases.

Biochemistry 39:13233-40 (2000)
DOI:10.1021/bi001154u

[kpn:KPN_01559]