| Entry |
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| Name |
CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase;
carS (gene name);
CDP-2,3-di-O-geranylgeranyl-sn-glycerol synthase;
CTP:2,3-GG-GP ether cytidylyltransferase;
CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase;
CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol synthase;
CTP:2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phosphate cytidylyltransferase;
CDP-unsaturated archaeol synthase;
CDP-archaeol synthase (incorrect)
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| Class |
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
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| Sysname |
CTP:2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate cytidylyltransferase
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| Reaction(IUBMB) |
CTP + 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate = diphosphate + CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol [RN: R08966]
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| Reaction(KEGG) |
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| Substrate |
CTP [CPD: C00063];
2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
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| Product |
diphosphate [CPD: C00013];
CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
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| Comment |
This enzyme catalyses one of the steps in the biosynthesis of polar lipids in archaea, which are characterized by having an sn-glycerol 1-phosphate backbone rather than an sn-glycerol 3-phosphate backbone as is found in bacteria and eukaryotes [1]. The enzyme requires Mg2+ and K+ for maximal activity [1].
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| History |
EC 2.7.7.67 created 2009, modified 2014
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| Pathway |
| ec00564 | Glycerophospholipid metabolism |
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| Orthology |
| K19664 | CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase |
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| Genes |
» show all
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| Reference |
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| Authors |
Morii H, Nishihara M, Koga Y |
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| Title |
CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase in the methanogenic archaeon Methanothermobacter thermoautotrophicus. |
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| Journal |
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| Reference |
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| Authors |
Morii H, Koga Y |
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| Title |
CDP-2,3-Di-O-geranylgeranyl-sn-glycerol:L-serine O-archaetidyltransferase (archaetidylserine synthase) in the methanogenic archaeon Methanothermobacter thermautotrophicus. |
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| Journal |
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| Reference |
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| Authors |
Jain S, Caforio A, Fodran P, Lolkema JS, Minnaard AJ, Driessen AJ |
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| Title |
Identification of CDP-archaeol synthase, a missing link of ether lipid biosynthesis in Archaea. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.7.7.67 |
| ExPASy - ENZYME nomenclature database: | 2.7.7.67 |
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| LinkDB |
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