| Entry |
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| Name |
D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase;
hddC (gene name);
gmhD (gene name)
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| Class |
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
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| Sysname |
GTP:D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase
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| Reaction(IUBMB) |
D-glycero-alpha-D-manno-heptose 1-phosphate + GTP = GDP-D-glycero-alpha-D-manno-heptose + diphosphate [RN: R09772]
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| Reaction(KEGG) |
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| Substrate |
D-glycero-alpha-D-manno-heptose 1-phosphate [CPD: C19880];
GTP [CPD: C00044]
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| Product |
GDP-D-glycero-alpha-D-manno-heptose [CPD: C19881];
diphosphate [CPD: C00013]
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| Comment |
The enzyme is involved in biosynthesis of GDP-D-glycero-alpha-D-manno-heptose, which is required for assembly of S-layer glycoprotein in some Gram-positive bacteria.
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| History |
EC 2.7.7.71 created 2010
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| Pathway |
| ec00540 | Lipopolysaccharide biosynthesis |
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| Orthology |
| K15669 | D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase |
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| Genes |
» show all
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| Reference |
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| Authors |
Kneidinger B, Graninger M, Puchberger M, Kosma P, Messner P |
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| Title |
Biosynthesis of nucleotide-activated D-glycero-D-manno-heptose. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.7.7.71 |
| ExPASy - ENZYME nomenclature database: | 2.7.7.71 |
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| LinkDB |
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