KEGG   ENZYME: 2.7.7.74
Entry
EC 2.7.7.74                 Enzyme                                 

Name
1L-myo-inositol 1-phosphate cytidylyltransferase;
CTP:inositol-1-phosphate cytidylyltransferase (bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS));
IPCT (bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase (IPCT/DIPPS));
L-myo-inositol-1-phosphate cytidylyltransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
Sysname
CTP:1L-myo-inositol 1-phosphate cytidylyltransferase
Reaction(IUBMB)
CTP + 1L-myo-inositol 1-phosphate = diphosphate + CDP-1L-myo-inositol [RN:R09669]
Reaction(KEGG)
R09669
Substrate
CTP [CPD:C00063];
1L-myo-inositol 1-phosphate [CPD:C04006]
Product
diphosphate [CPD:C00013];
CDP-1L-myo-inositol [CPD:C19794]
Comment
In many organisms this activity is catalysed by a bifunctional enzyme. The cytidylyltransferase domain of the bifunctional EC 2.7.7.74/EC 2.7.8.34 (CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase) is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. The enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments.
History
EC 2.7.7.74 created 2011
Pathway
ec00562  Inositol phosphate metabolism
Orthology
K07281  1L-myo-inositol 1-phosphate cytidylyltransferase
K23992  1L-myo-inositol 1-phosphate cytidylyltransferase / CDP-L-myo-inositol myo-inositolphosphotransferase
Genes
MTHD: A3224_07290
ENM: EBS_0412
CCRO: CMC5_034520 CMC5_075830
DAO: Desac_2272
SFU: Sfum_2920 Sfum_2923
BSED: DN745_05540 DN745_10835
PCAY: FRD00_02815 FRD00_21750
NAR: Saro_0100 Saro_0102
NOT: C7W88_05615
NOR: FA702_11445 FA702_11455
NGF: FRF71_04960
NOG: GKE62_14325
STAX: MC45_06680
SNJ: A7E77_02155
SMY: BJP26_11175
SKR: BRX40_00985
SPLM: BXU08_09805
SPLK: AV944_05835
SPHC: CVN68_10510
SPHF: DM480_12980
SMIC: SmB9_25590 SmB9_25610
SPHS: ETR14_18250
SPHJ: BSL82_01690
SAND: H3309_10530 H3309_10540
ERY: CP97_03755 CP97_03775
PORL: BG023_11492 BG023_11496
PHZ: CHX26_13940 CHX26_13960
GBE: GbCGDNIH1_0237
GBH: GbCGDNIH2_0237
GBC: GbCGDNIH3_0237
GBS: GbCGDNIH4_0237
GDI: GDI0629(hasC)
GDJ: Gdia_1377
NAO: Y958_26660
ECOG: FIV45_08015 FIV45_13855
NTR: B0W44_00905
TMR: Tmar_0126
THEF: E1B22_04180
THEP: DYI95_000435
TPZ: Tph_c20790
RXY: Rxyl_1212
TBH: Tbon_07190
TTR: Tter_0472
SSM: Spirs_4227
RMR: Rmar_1196
RMG: Rhom172_1617
NOB: CW736_12840
CACI: CLOAM0421
AAE: aq_1367(spsI)
PMX: PERMA_1921
TTK: TST_0884
TMM: Tmari_1425
TMI: THEMA_07220
TMW: THMA_1449
TMQ: THMB_1449
TMX: THMC_1449
TPT: Tpet_1374
TRQ: TRQ2_1312
TNA: CTN_1074
TNP: Tnap_1392
THQ: T2812B_07090
THZ: CELL2_07150
THR: TRQ7_06825
CABY: Cabys_1832
NDE: NIDE0736
NMV: NITMOv2_0605
NIO: NITINOP_0313
NJA: NSJP_1717
TID: Thein_0126
TAV: G4V39_06760
TMAI: FVE67_04000
MOX: DAMO_2608
MIF: Metin_0454
MIG: Metig_1787
METF: CFE53_00410
AFU: AF_0263
AFG: AFULGI_00002550
APO: Arcpr_0766
AVE: Arcve_1159 Arcve_2013
AST: Asulf_00859
FPL: Ferp_0148 Ferp_0859
GAC: GACE_2065
GAH: GAH_01161
PFU: PF1058
PFI: PFC_04525
PHO: PH1219(PH1219)
PAB: PAB2433
PYN: PNA2_1704
PYA: PYCH_00120
PYS: Py04_1010
PYC: TQ32_04290
TKO: TK2279
TON: TON_1248
TGA: TGAM_1853
TSI: TSIB_1010
TBA: TERMP_01130
THE: GQS_09430
THA: TAM4_5
THM: CL1_1475
TLT: OCC_08385
THS: TES1_1181
TNU: BD01_1626
TEU: TEU_00190
TCH: CHITON_0904
TPEP: A0127_03970
TGG: A3K92_01915
TCE: A3L02_05685
TBS: A3L01_06850
THH: CDI07_06820
TSL: A3L11_01110
TTD: A3L14_09240
TPRF: A3L09_03245
TRL: A3L10_06295
TPAF: A3L08_00135
THY: A3L12_02080
PPAC: PAP_05835
NAC: AQV86_00780
APE: APE_1514.1
ACJ: ACAM_0951
IAG: Igag_0487
HBU: Hbut_0150
PFM: Pyrfu_0046
PDL: Pyrde_0746
TPE: Tpen_1250 Tpen_1251
THB: N186_00105
THEL: IG193_09070
KCR: Kcr_0184
BARC: AOA65_0707
 » show all
Reference
1  [PMID:17526717]
  Authors
Rodrigues MV, Borges N, Henriques M, Lamosa P, Ventura R, Fernandes C, Empadinhas N, Maycock C, da Costa MS, Santos H
  Title
Bifunctional CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase, the key enzyme for di-myo-inositol-phosphate synthesis in several (hyper)thermophiles.
  Journal
J Bacteriol 189:5405-12 (2007)
DOI:10.1128/JB.00465-07
  Sequence
[aae:aq_1367] [afu:AF_0263] [pfu:PF1058][rxy:Rxyl_1212] [tko:TK2279]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.74
IUBMB Enzyme Nomenclature: 2.7.7.74
ExPASy - ENZYME nomenclature database: 2.7.7.74
BRENDA, the Enzyme Database: 2.7.7.74
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