KEGG   ENZYME: 2.7.7.82
Entry
EC 2.7.7.82                 Enzyme                                 

Name
CMP-N,N'-diacetyllegionaminic acid synthase;
CMP-N,N'-diacetyllegionaminic acid synthetase;
neuA (gene name);
legF (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
Sysname
CTP:N,N'-diacetyllegionaminate cytidylyltransferase
Reaction(IUBMB)
CTP + N,N'-diacetyllegionaminate = CMP-N,N'-diacetyllegionaminate + diphosphate [RN:R10182]
Reaction(KEGG)
R10182
Substrate
CTP [CPD:C00063];
N,N'-diacetyllegionaminate [CPD:C20418]
Product
CMP-N,N'-diacetyllegionaminate [CPD:C20419];
diphosphate [CPD:C00013]
Comment
Isolated from the bacteria Legionella pneumophila and Campylobacter jejuni. Involved in biosynthesis of legionaminic acid, a sialic acid-like derivative that is incorporated into virulence-associated cell surface glycoconjugates which may include lipopolysaccharide (LPS), capsular polysaccharide, pili and flagella.
History
EC 2.7.7.82 created 2012
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
Orthology
K18431  CMP-N,N'-diacetyllegionaminic acid synthase
Genes
ECAN: CWI88_07880
LEF: LJPFL01_2718
SRL: SOD_c14550(ptmB)
SQU: E4343_08210
SOF: NCTC11214_05338(neuA)
PPAR: A8F97_19530
VCZ: VAB027_3598
VVY: VV0316
VVL: VV93_v1c03060
VPH: VPUCM_0206
VTA: A3008(neuA)
VFI: VF_0147(neuA)
AWD: AWOD_I_0144(neuA)
PSYC: DABAL43B_0735(neuA)
SSE: Ssed_3104
SWD: Swoo_1578
SPSW: Sps_03735
ILO: IL0518(siaB)
PTU: PTUN_a3142(neuA)
MARJ: MARI_04490(neuA)
SALH: HMF8227_01144(neuA)
MVS: MVIS_3783(siaB)
LPN: lpg0751(neuA)
LPH: LPV_0877(neuA)
LPO: LPO_0832(neuA)
LPM: LP6_0731(neuA)
LPF: lpl0788(neuA)
LPP: lpp0817(neuA)
LPC: LPC_2541(neuA)
LPA: lpa_01159(neuA)
LPE: lp12_0761
LFA: LFA_0803
LHA: LHA_1169
LCD: clem_09295(neuA_1) clem_09325(neuA_2) clem_09390(neuA_3) clem_09460(neuA_4)
LWA: SAMEA4504053_1065(neuA)
METL: U737_04555
FPH: Fphi_1170
FPI: BF30_1414
FPX: KU46_144
FRC: KX01_1743
TCX: Tcr_1455
TEE: Tel_05530
GAI: IMCC3135_21680(neuA_1) IMCC3135_22670(neuA_2)
AVR: B565_2788
ACAV: VI35_13855
SLIM: SCL_1208
TBN: TBH_C0743
VEI: Veis_4851
CBX: Cenrod_0010(neuA)
TIN: Tint_2653
THI: THI_3182
NEU: NE1569(neuA1)
NET: Neut_1548
HAC: Hac_1269(neuA)
HMS: HMU06140(siaB)
HFE: HFELIS_02740(siaB)
HCE: HCW_07295
HCM: HCD_01685
HCL: NCTC13205_00836(siaB)
SULR: B649_08520
CJE: Cj1331(ptmB)
CJB: BN148_1331(ptmB)
CJU: C8J_1333
CJI: CJSA_1267(ptmB)
CJS: CJS3_1425
CJEJ: N564_02275
CJEU: N565_02365
CJEN: N755_02425
CJEI: N135_01419
CJER: H730_07610
CJY: QZ67_01222(neuA) QZ67_01467(legF_2)
CJQ: UC78_1274(legF_2)
CJR: CJE1520(ptmB)
CJD: JJD26997_0378(ptmB)
CCO: CCC13826_2299(legF)
CCOC: CCON33237_1634(legF)
CLA: CLA_1229(legF)
CCQ: N149_1294(legF)
CCF: YSQ_02195
CCOI: YSU_02230
CCOF: VC76_06680(legF_2)
CCOO: ATE51_00902(legF_2)
CIS: CINS_1190(legF) CINS_1203(neuA)
CVO: CVOL_1210(legF)
CSM: CSUB8521_1413(legF)
CSF: CSUB8523_1513(legF)
CHV: CHELV3228_1651(legF)
CLX: CLAN_1245(legF)
CAVI: CAV_1245(legF)
CAMZ: CVIC12175_0318(legF)
CAMY: CSUIS_1332(legF)
ABT: ABED_0623
AMYT: AMYT_0901
ATP: ATR_1810
AELL: AELL_2678
HBV: ABIV_2485
ARC: ABLL_0815
DEU: DBW_1496
DVL: Dvul_2588
DAS: Daes_1989
DPI: BN4_12686
DTO: TOL2_C35410(neuA)
RBS: RHODOSMS8_01664(legF)
RLG: Rleg_0443
RHT: NT26_3158
BJA: blr5996(ptmB)
BRAD: BF49_5664
RPB: RPB_1536
RPE: RPE_4239
NWI: Nwi_2397
MCH: Mchl_3990
BVR: BVIR_1973
BLAG: BLTE_00370
RBM: TEF_17260
OTM: OSB_23460(legF)
LVS: LOKVESSMR4R_02195(legF)
RCE: RC1_3768(neuA)
MGY: MGMSRv2__3413(ptmB)
MGRY: MSR1_31150(neuA)
MAGX: XM1_0964
MAGN: WV31_13100
MGM: Mmc1_0559
BBA: Bd1686(neuA)
BPUM: BW16_10400
BPUS: UP12_09695
BACW: QR42_09650
PPY: PPE_04402
SIV: SSIL_3274
EFU: HMPREF0351_10922(neuA)
CARC: NY10_945
CBL: CLK_2102
CBB: CLD_1850
CBM: CBF_2765
CKL: CKL_2466(neuA)
CKR: CKR_2180
HHW: NCTC503_01055(neuA_1)
CTH: Cthe_2639
HSC: HVS_09970(legF)
BPB: bpr_I0432(neuA1)
CST: CLOST_0369(neuA)
AWO: Awo_c24820(neuA)
CTHM: CFE_2504
TIT: Thit_0484
MTHO: MOTHE_c07020(neuA)
MTHZ: MOTHA_c07960(neuA)
TSH: Tsac_2665
MANA: MAMMFC1_02390(neuA)
LPIL: LIP_2374
SYW: SYNW0444
SYG: sync_0182(neuA-2)
PRC: EW14_1450
NSP: BMF81_04461(legF)
OBG: Verru16b_02057(neuA)
GMR: GmarT_17210(neuA)
BVO: Pan97_06830(neuA)
KST: KSMBR1_2320(neuA)
TPED: TPE_0202
LIL: LA_1605(neuA)
LIE: LIF_A1292(neuA)
LIC: LIC_12177(neuA)
LST: LSS_16491
BUN: Bun01g_24060(neuA)
TFO: BFO_1063
DFE: Dfer_3365
GFO: GFO_0572(neuA)
GFL: GRFL_2398
FIN: KQS_03405(neuA)
ZPR: ZPR_1113
NDO: DDD_3551
KOS: KORDIASMS9_03605(neuA)
KAN: IMCC3317_05770(neuA)
PPH: Ppha_0534
PROC: Ptc2401_00369(neuA)
TTK: TST_1476(neuA)
NDE: NIDE3000(neuA)
CGW: UR58_C0001G0067(neuA)
MBU: Mbur_1585
HMU: Hmuk_1467
NIN: NADRNF5_2152(neuA)
 » show all
Reference
1  [PMID:18275154]
  Authors
Glaze PA, Watson DC, Young NM, Tanner ME
  Title
Biosynthesis of CMP-N,N'-diacetyllegionaminic acid from UDP-N,N'-diacetylbacillosamine in Legionella pneumophila.
  Journal
Biochemistry 47:3272-82 (2008)
DOI:10.1021/bi702364s
  Sequence
[lpn:lpg0751]
Reference
2  [PMID:19282391]
  Authors
Schoenhofen IC, Vinogradov E, Whitfield DM, Brisson JR, Logan SM
  Title
The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel  GDP-linked precursors.
  Journal
Glycobiology 19:715-25 (2009)
DOI:10.1093/glycob/cwp039
  Sequence
[cje:Cj1331]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.82
IUBMB Enzyme Nomenclature: 2.7.7.82
ExPASy - ENZYME nomenclature database: 2.7.7.82
BRENDA, the Enzyme Database: 2.7.7.82
LinkDB

DBGET integrated database retrieval system