Entry |
|
Name |
cyclic GMP-AMP synthase;
cGAMP synthase;
cGAS
|
Class |
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
|
Sysname |
ATP:GTP adenylyltransferase (cyclizing)
|
Reaction(IUBMB) |
ATP + GTP = 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5') (overall reaction) [RN: R10462];
(1a) ATP + GTP = pppGp(2'-5')A + diphosphate;
(1b) pppGp(2'-5')A = cyclic Gp(2'-5')Ap(3'-5') + diphosphate
|
Reaction(KEGG) |
|
Substrate |
|
Product |
diphosphate [CPD: C00013];
cyclic Gp(2'-5')Ap(3'-5') [CPD: C20640];
pppGp(2'-5')A
|
Comment |
Cyclic Gp(2'-5')Ap(3'-5') is a signalling molecule in mammalian cells that triggers the production of type I interferons and other cytokines.
|
History |
EC 2.7.7.86 created 2013, modified 2014
|
Orthology |
K17834 | cyclic GMP-AMP synthase |
|
Genes |
» show all
|
Reference |
|
Authors |
Sun L, Wu J, Du F, Chen X, Chen ZJ |
Title |
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. |
Journal |
|
Sequence |
|
Reference |
|
Authors |
Ablasser A, Goldeck M, Cavlar T, Deimling T, Witte G, Rohl I, Hopfner KP, Ludwig J, Hornung V. |
Title |
cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING. |
Journal |
|
Other DBs |
ExplorEnz - The Enzyme Database: | 2.7.7.86 |
ExPASy - ENZYME nomenclature database: | 2.7.7.86 |
|
LinkDB |
|