KEGG   ENZYME: 2.7.7.88
Entry
EC 2.7.7.88                 Enzyme                                 

Name
GDP polyribonucleotidyltransferase;
PRNTase;
5'-triphospho-mRNA:GDP 5'-phosphopolyribonucleotidyltransferase [G(5')ppp-mRNA-forming]
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
Sysname
(5')pppAACA-[mRNA]:GDP 5'-phosphopolyribonucleotidyltransferase [(5')pppAACA-[mRNA]-forming]
Reaction(IUBMB)
(5')pppAACA-[mRNA] + GDP = diphosphate + G(5')pppAACA-[mRNA] (overall reaction);
(1a) (5')pppAACA-[mRNA] + [protein L]-L-histidine = diphosphate + [protein L]-L-histidyl-(5')phosphonato-AACA-[mRNA] + H2O;
(1b) [protein L]-L-histidyl-(5')phosphonato-AACA-[mRNA] + GDP + H2O = [protein L]-L-histidine + G(5')pppAACA-[mRNA]
Reaction(KEGG)
(other) R11203
Substrate
5'-triphospho-mRNA [CPD:C20864];
GDP [CPD:C00035]
Product
diphosphate [CPD:C00013];
G(5')pppAACA-[mRNA];
[protein L]-L-histidyl-(5')phosphonato-AACA-[mRNA];
H2O [CPD:C00001];
[protein L]-L-histidine
Comment
The enzyme from non-segmented negative strain (NNS) viruses (e.g. rhabdoviruses and lyssaviruses) is specific for mRNAs with sequences starting with AACA. cf. EC 2.7.7.50, mRNA guanylyltransferase.
History
EC 2.7.7.88 created 2015, modified 2020
Orthology
K21316  Rhabdoviridae RNA-directed RNA polymerase
Reference
1  [PMID:17218273]
  Authors
Ogino T, Banerjee AK
  Title
Unconventional mechanism of mRNA capping by the RNA-dependent RNA polymerase of vesicular stomatitis virus.
  Journal
Mol Cell 25:85-97 (2007)
DOI:10.1016/j.molcel.2006.11.013
Reference
2  [PMID:18495767]
  Authors
Ogino T, Banerjee AK
  Title
Formation of guanosine(5')tetraphospho(5')adenosine cap structure by an unconventional mRNA capping enzyme of vesicular stomatitis virus.
  Journal
J Virol 82:7729-34 (2008)
DOI:10.1128/JVI.00326-08
Reference
3  [PMID:20142503]
  Authors
Ogino T, Yadav SP, Banerjee AK
  Title
Histidine-mediated RNA transfer to GDP for unique mRNA capping by vesicular stomatitis virus RNA polymerase.
  Journal
Proc Natl Acad Sci U S A 107:3463-8 (2010)
DOI:10.1073/pnas.0913083107
Reference
4  [PMID:20107017]
  Authors
Ogino T, Banerjee AK
  Title
The HR motif in the RNA-dependent RNA polymerase L protein of Chandipura virus is required for unconventional mRNA-capping activity.
  Journal
J Gen Virol 91:1311-4 (2010)
DOI:10.1099/vir.0.019307-0
Reference
5  [PMID:21945214]
  Authors
Ogino T, Banerjee AK
  Title
An unconventional pathway of mRNA cap formation by vesiculoviruses.
  Journal
Virus Res 162:100-9 (2011)
DOI:10.1016/j.virusres.2011.09.012
  Sequence
[vg:1489835]
Reference
6  [PMID:27213429]
  Authors
Ogino M, Ito N, Sugiyama M, Ogino T.
  Title
The Rabies Virus L Protein Catalyzes mRNA Capping with GDP Polyribonucleotidyltransferase Activity.
  Journal
Viruses 8:E144 (2016)
DOI:10.3390/v8050144
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.88
IUBMB Enzyme Nomenclature: 2.7.7.88
ExPASy - ENZYME nomenclature database: 2.7.7.88
BRENDA, the Enzyme Database: 2.7.7.88
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