| Entry |
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| Name |
3-deoxy-D-glycero-D-galacto-nonulopyranosonate cytidylyltransferase
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| Class |
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
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| Sysname |
CTP:3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate cytidylyltransferase
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| Reaction(IUBMB) |
CTP + 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate = diphosphate + CMP-3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate [RN: R11441]
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| Reaction(KEGG) |
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| Substrate |
CTP [CPD: C00063];
3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate
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| Product |
diphosphate [CPD: C00013];
CMP-3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate
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| Comment |
The enzyme is part of the biosynthesis pathway of the sialic acid 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate (Kdn). Kdn is abundant in extracellular glycoconjugates of lower vertebrates such as fish and amphibians, but is also found in the capsular polysaccharides of bacteria that belong to the Bacteroides genus.
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| History |
EC 2.7.7.92 created 2016
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| Orthology |
| K21749 | N-acylneuraminate/3-deoxy-D-glycero-D-galacto-nononate cytidylyltransferase |
| K21750 | 3-deoxy-D-glycero-D-galacto-nononate cytidylyltransferase |
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| Genes |
» show all
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| Reference |
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| Authors |
Terada T, Kitazume S, Kitajima K, Inoue S, Ito F, Troy FA, Inoue Y |
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| Title |
Synthesis of CMP-deaminoneuraminic acid (CMP-KDN) using the CTP:CMP-3-deoxynonulosonate cytidylyltransferase from rainbow trout testis. Identification and characterization of a CMP-KDN synthetase. |
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| Journal |
J Biol Chem 268:2640-8 (1993) |
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| Reference |
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| Authors |
Terada T, Kitajima K, Inoue S, Koppert K, Brossmer R, Inoue Y |
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| Title |
Substrate specificity of rainbow trout testis CMP-3-deoxy-D-glycero-D-galacto-nonulosonic acid (CMP-Kdn) synthetase: kinetic studies of the reaction of natural and synthetic analogues of nonulosonic acid catalyzed by CMP-Kdn synthetase. |
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| Journal |
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| Reference |
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| Authors |
Nakata D, Munster AK, Gerardy-Schahn R, Aoki N, Matsuda T, Kitajima K |
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| Title |
Molecular cloning of a unique CMP-sialic acid synthetase that effectively utilizes both deaminoneuraminic acid (KDN) and N-acetylneuraminic acid (Neu5Ac) as substrates. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Tiralongo J, Fujita A, Sato C, Kitajima K, Lehmann F, Oschlies M, Gerardy-Schahn R, Munster-Kuhnel AK |
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| Title |
The rainbow trout CMP-sialic acid synthetase utilises a nuclear localization signal different from that identified in the mouse enzyme. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Wang L, Lu Z, Allen KN, Mariano PS, Dunaway-Mariano D |
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| Title |
Human symbiont Bacteroides thetaiotaomicron synthesizes 2-keto-3-deoxy-D-glycero-D- galacto-nononic acid (KDN). |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.7.7.92 |
| ExPASy - ENZYME nomenclature database: | 2.7.7.92 |
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| LinkDB |
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