KEGG   ENZYME: 2.7.8.32
Entry
EC 2.7.8.32                 Enzyme                                 
Name
3-O-alpha-D-mannopyranosyl-alpha-D-mannopyranose xylosylphosphotransferase;
XPT1
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
Sysname
UDP-D-xylose:3-O-alpha-D-mannopyranosyl-alpha-D-mannopyranose xylosylphosphotransferase
Reaction(IUBMB)
UDP-xylose + 3-O-alpha-D-mannopyranosyl-alpha-D-mannopyranose = UMP + 3-O-(6-O-alpha-D-xylosylphospho-alpha-D-mannopyranosyl)-alpha-D-mannopyranose [RN:R09642]
Reaction(KEGG)
R09642
Substrate
UDP-xylose [CPD:C00190];
3-O-alpha-D-mannopyranosyl-alpha-D-mannopyranose [CPD:C19773]
Product
UMP [CPD:C00105];
3-O-(6-O-alpha-D-xylosylphospho-alpha-D-mannopyranosyl)-alpha-D-mannopyranose [CPD:C19774]
Comment
Mn2+ required for activity. The enzyme is specific for mannose as an acceptor but is flexible as to the structural context of the mannosyl disaccharide.
History
EC 2.7.8.32 created 2011
Orthology
K18706  3-O-alpha-D-mannopyranosyl-alpha-D-mannopyranose xylosylphosphotransferase
Genes
CNECNJ02890
CNBCNBJ0640
CGICGB_I4040W
TMSTREMEDRAFT_67553
TASAA1Q1_04917
Reference
1  [PMID:19864415]
  Authors
Reilly MC, Levery SB, Castle SA, Klutts JS, Doering TL
  Title
A novel xylosylphosphotransferase activity discovered in Cryptococcus neoformans.
  Journal
J Biol Chem 284:36118-27 (2009)
DOI:10.1074/jbc.M109.056226
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.8.32
IUBMB Enzyme Nomenclature: 2.7.8.32
ExPASy - ENZYME nomenclature database: 2.7.8.32
BRENDA, the Enzyme Database: 2.7.8.32
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