| Entry |
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| Name |
Kdo2-lipid A phosphoethanolamine 7''-transferase;
eptB (gene name)
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| Class |
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
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| Sysname |
diacylphosphatidylethanolamine:alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid-A 7''-phosphoethanolaminetransferase
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| Reaction(IUBMB) |
(1) diacylphosphatidylethanolamine + alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A = diacylglycerol + 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A [RN: R11204];
(2) diacylphosphatidylethanolamine + alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid IVA = diacylglycerol + 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid IVA [RN: R11205]
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| Reaction(KEGG) |
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| Substrate |
diacylphosphatidylethanolamine [CPD: C00350];
alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A [CPD: C06026];
alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid IVA [CPD: C06025]
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| Product |
diacyglycerol [CPD: C00641];
7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A [CPD: C21173];
7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid IVA [CPD: C21174]
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| Comment |
The enzyme has been characterized from the bacterium Escherichia coli. It is activated by Ca2+ ions and is silenced by the sRNA MgrR.
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| History |
EC 2.7.8.42 created 2015
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| Pathway |
| ec00540 | Lipopolysaccharide biosynthesis |
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| Orthology |
| K12975 | KDO II ethanolaminephosphotransferase |
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| Genes |
» show all
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| Reference |
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| Authors |
Kanipes MI, Lin S, Cotter RJ, Raetz CR |
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| Title |
Ca2+-induced phosphoethanolamine transfer to the outer 3-deoxy-D-manno-octulosonic acid moiety of Escherichia coli lipopolysaccharide. A novel membrane enzyme dependent upon phosphatidylethanolamine. |
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| Journal |
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| Reference |
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| Authors |
Reynolds CM, Kalb SR, Cotter RJ, Raetz CR |
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| Title |
A phosphoethanolamine transferase specific for the outer 3-deoxy-D-manno-octulosonic acid residue of Escherichia coli lipopolysaccharide. Identification of the eptB gene and Ca2+ hypersensitivity of an eptB deletion mutant. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Moon K, Six DA, Lee HJ, Raetz CR, Gottesman S |
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| Title |
Complex transcriptional and post-transcriptional regulation of an enzyme for lipopolysaccharide modification. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.7.8.42 |
| ExPASy - ENZYME nomenclature database: | 2.7.8.42 |
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| LinkDB |
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