| Entry |
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| Name |
lipid A phosphoethanolamine transferase;
lipid A PEA transferase;
LptA
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| Class |
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
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| Sysname |
diacylphosphatidylethanolamine:lipid-A ethanolaminephosphotransferase
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| Reaction(IUBMB) |
(1) diacylphosphatidylethanolamine + lipid A = diacylglycerol + lipid A 1-(2-aminoethyl diphosphate);
(2) diacylphosphatidylethanolamine + lipid A = diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate);
(3) diacylphosphatidylethanolamine + lipid A 1-(2-aminoethyl diphosphate) = diacylglycerol + lipid A 1,4'-bis(2-aminoethyl diphosphate)
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| Reaction(KEGG) |
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| Substrate |
diacylphosphatidylethanolamine;
lipid A;
lipid A 1-(2-aminoethyl diphosphate)
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| Product |
diacylglycerol [CPD: C00165];
lipid A 1-(2-aminoethyl diphosphate);
lipid A 4'-(2-aminoethyl diphosphate);
lipid A 1,4'-bis(2-aminoethyl diphosphate)
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| Comment |
The enzyme adds one or two ethanolamine phosphate groups to lipid A giving a diphosphate, sometimes in combination with EC 2.4.2.43 (lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase) giving products with 4-amino-4-deoxy-beta-L-arabinose groups at the phosphates of lipid A instead of diphosphoethanolamine groups. It will also act on lipid IVA and Kdo2-lipid A.
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| History |
EC 2.7.8.43 created 2015 as EC 2.7.4.30, transferred 2016 to EC 2.7.8.43
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| Pathway |
| ec00540 | Lipopolysaccharide biosynthesis |
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| Orthology |
| K03760 | lipid A ethanolaminephosphotransferase |
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| Genes |
» show all
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| Reference |
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| Authors |
Tran AX, Karbarz MJ, Wang X, Raetz CR, McGrath SC, Cotter RJ, Trent MS |
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| Title |
Periplasmic cleavage and modification of the 1-phosphate group of Helicobacter pylori lipid A. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Herrera CM, Hankins JV, Trent MS |
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| Title |
Activation of PmrA inhibits LpxT-dependent phosphorylation of lipid A promoting resistance to antimicrobial peptides. |
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| Journal |
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| Reference |
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| Authors |
Cullen TW, Trent MS |
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| Title |
A link between the assembly of flagella and lipooligosaccharide of the Gram-negative bacterium Campylobacter jejuni. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Anandan A, Piek S, Kahler CM, Vrielink A |
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| Title |
Cloning, expression, purification and crystallization of an endotoxin-biosynthesis enzyme from Neisseria meningitidis. |
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| Journal |
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| Reference |
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| Authors |
Wanty C, Anandan A, Piek S, Walshe J, Ganguly J, Carlson RW, Stubbs KA, Kahler CM, Vrielink A |
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| Title |
The structure of the neisserial lipooligosaccharide phosphoethanolamine transferase A (LptA) required for resistance to polymyxin. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.7.8.43 |
| ExPASy - ENZYME nomenclature database: | 2.7.8.43 |
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| LinkDB |
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