| Entry |
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| Name |
molybdopterin synthase sulfurtransferase;
adenylyltransferase and sulfurtransferase MOCS3;
Cnx5 (gene name);
molybdopterin synthase sulfurylase
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| Class |
Transferases;
Transferring sulfur-containing groups;
Sulfurtransferases
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| Sysname |
[cysteine desulfurase]-S-sulfanyl-L-cysteine:[molybdopterin-synthase sulfur-carrier protein]-Gly-Gly sulfurtransferase
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| Reaction(IUBMB) |
[molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine + reduced acceptor = AMP + [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + [cysteine desulfurase]-L-cysteine + oxidized acceptor [RN: R07461]
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| Reaction(KEGG) |
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| Substrate |
[molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP [CPD: C15813];
[cysteine desulfurase]-S-sulfanyl-L-cysteine [CPD: C15812];
reduced acceptor [CPD: C00030]
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| Product |
AMP [CPD: C00020];
[molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH2-C(O)SH [CPD: C15814];
[cysteine desulfurase] [CPD: C15811];
oxidized acceptor [CPD: C00028]
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| Comment |
The enzyme transfers sulfur to form a thiocarboxylate moiety on the C-terminal glycine of the small subunit of EC 2.8.1.12, molybdopterin synthase. In the human, the reaction is catalysed by the rhodanese-like C-terminal domain (cf. EC 2.8.1.1) of the MOCS3 protein, a bifunctional protein that also contains EC 2.7.7.80, molybdopterin-synthase adenylyltransferase, at the N-terminal domain.
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| History |
EC 2.8.1.11 created 2011, modified 2016
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| Orthology |
| K11996 | adenylyltransferase and sulfurtransferase |
| K21028 | molybdopterin synthase sulfurtransferase |
| K21147 | sulfur-carrier protein adenylyltransferase/sulfurtransferase |
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| Genes |
» show all
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| Reference |
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| Authors |
Matthies A, Nimtz M, Leimkuhler S |
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| Title |
Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Leimkuhler S, Rajagopalan KV |
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| Title |
A sulfurtransferase is required in the transfer of cysteine sulfur in the in vitro synthesis of molybdopterin from precursor Z in Escherichia coli. |
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| Journal |
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| Reference |
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| Authors |
Hanzelmann P, Dahl JU, Kuper J, Urban A, Muller-Theissen U, Leimkuhler S, Schindelin H |
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| Title |
Crystal structure of YnjE from Escherichia coli, a sulfurtransferase with three rhodanese domains. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Dahl JU, Urban A, Bolte A, Sriyabhaya P, Donahue JL, Nimtz M, Larson TJ, Leimkuhler S |
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| Title |
The identification of a novel protein involved in molybdenum cofactor biosynthesis in Escherichia coli. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.8.1.11 |
| ExPASy - ENZYME nomenclature database: | 2.8.1.11 |
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| LinkDB |
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