| Entry |
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| Name |
lipoprotein lipase;
clearing factor lipase;
diacylglycerol lipase;
postheparin esterase;
diglyceride lipase;
postheparin lipase;
diacylglycerol hydrolase;
lipemia-clearing factor;
hepatic triacylglycerol lipase;
LIPC (gene name);
LPL (gene name);
triacylglycero-protein acylhydrolase
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| Class |
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
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| Sysname |
triacylglycerol acylhydrolase (lipoprotein-dependent)
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| Reaction(IUBMB) |
triacylglycerol + H2O = diacylglycerol + a carboxylate [RN: R01369]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Hydrolyses triacylglycerols and diacylglycerol in chylomicrons and low-density lipoprotein particles. Human protein purified from post-heparin plasma (LPL) shows no activity against triglyceride in the absence of added lipoprotein. The principal reaction sequence of that enzyme is triglyceride -> 1,2-diglyceride -> 2-monoglyceride. The hepatic enzyme (LIPC) also hydrolyses triglycerides and phospholipids present in circulating plasma lipoproteins.
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| History |
EC 3.1.1.34 created 1972, modified 1976
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| Pathway |
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| Orthology |
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| Genes |
» show all
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| Reference |
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| Authors |
Egelrud T, Olivecrona T. |
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| Title |
Purified bovine milk (lipoprotein) lipase: activity against lipid substrates in the absence of exogenous serum factors. |
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| Journal |
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| Reference |
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| Authors |
Fielding CJ. |
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| Title |
Human lipoprotein lipase. I. Purification and substrate specificity. |
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| Journal |
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| Reference |
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| Authors |
Greten H, Levy RI, Fales H, Fredrickson DS. |
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| Title |
Hydrolysis of diglyceride and glyceryl monoester diethers with "lipoprotein lipase". |
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| Journal |
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| Reference |
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| Authors |
Morley N, Kuksis A. |
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| Title |
Positional specificity of lipoprotein lipase. |
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| Journal |
J Biol Chem 247:6389-93 (1972) |
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| Reference |
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| Authors |
Nilsson-Ehle P, Belfrage P, Borgstrom B. |
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| Title |
Purified human lipoprotein lipase: positional specificity. |
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| Journal |
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| Reference |
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| Authors |
Santamarina-Fojo S, Gonzalez-Navarro H, Freeman L, Wagner E, Nong Z |
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| Title |
Hepatic lipase, lipoprotein metabolism, and atherogenesis. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.1.1.34 |
| ExPASy - ENZYME nomenclature database: | 3.1.1.34 |
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| LinkDB |
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