KEGG ENZYME: 3.1.1.34

ENZYME: 3.1.1.34

Entry

EC 3.1.1.34 Enzyme

Name

lipoprotein lipase;
clearing factor lipase;
diglyceride lipase;
diacylglycerol lipase;
postheparin esterase;
diglyceride lipase;
postheparin lipase;
diacylglycerol hydrolase;
lipemia-clearing factor

Class

Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases

Sysname

triacylglycero-protein acylhydrolase

Reaction(IUBMB)

triacylglycerol + H2O = diacylglycerol + a carboxylate [RN:R01369]

Reaction(KEGG)

R01369;
(other) R01350

Substrate

triacylglycerol [CPD:C00422];
H2O [CPD:C00001]

Product

diacylglycerol [CPD:C00165];
carboxylate [CPD:C00060]

Comment

Hydrolyses triacylglycerols in chylomicrons and low-density lipoproteins. Also hydrolyses diacylglycerol.

History

EC 3.1.1.34 created 1972, modified 1976

Pathway

ec00561

Glycerolipid metabolism

Orthology

K01059

lipoprotein lipase

Genes

HSA:

4023(LPL)

PTR:	464031(LPL)

PPS:	100986925(LPL)

GGO:	101124245(LPL)

PON:	100443394(LPL)

NLE:	100584438(LPL)

MCC:	712887(LPL)

MCF:	102129758(LPL)

CSAB:

103215415(LPL)

RRO:	104662456(LPL)

RBB:	108526485(LPL)

CJC:	100409187(LPL)

SBQ:	101050033(LPL)

MMU:	16956(Lpl)

MCAL:

110299545(Lpl)

MPAH:

110336613(Lpl)

RNO:	24539(Lpl)

MUN:	110541256(Lpl)

CGE:	100689191(Lpl)

NGI:	103747648(Lpl)

HGL:	101703016(Lpl)

CCAN:

109695316 109695324(Lpl)

OCU:	100340171(LPL)

TUP:	102492328(LPL)

CFA:	403626(LPL)

VVP:	112925544(LPL)

AML:	100482804(LPL)

UMR:	103676703(LPL)

UAH:	113270022(LPL)

ORO:	101380450(LPL)

FCA:	727696(LPL)

PTG:	102967736(LPL)

AJU:	106971857(LPL)

BTA:	280843(LPL)

BOM:	102266770(LPL)

BIU:	109563092(LPL)

BBUB:

102412415(LPL)

PHD:	102341297(LPL)

CHX:	100860750(LPL)

OAS:	443408(LPL)

SSC:	397537(LPL)

CFR:	102520179(LPL)

CDK:	105094532(LPL)

BACU:

103005101

LVE:	103083746(LPL)

OOR:	101284828(LPL)

DLE:	111169014(LPL)

ECB:	100055358(LPL)

EPZ:	103559571(LPL)

EAI:	106831205(LPL)

MYB:	102247387(LPL)

MYD:	102759852(LPL)

MNA:	107535437(LPL)

HAI:	109382488(LPL)

RSS:	109450058(LPL)

DRO:	112305220(LPL)

PALE:

102892638(LPL)

LAV:	100667686(LPL)

TMU:

101345905

MDO:	100033067(LPL)

SHR:	100933361(LPL)

PCW:	110196400(LPL)

OAA:	100077350(LPL)

GGA:	396219(LPL)

MGP:	100544844(LPL)

CJO:	107306443(LPL)

APLA:

101796218(LPL)

ACYG:

106040417(LPL)

TGU:	100223817(LPL)

LSR:	110472801(LPL)

SCAN:

103821279(LPL)

GFR:	102041807(LPL)

FAB:	101814126(LPL)

PHI:	102111905(LPL)

PMAJ:

107216453(LPL)

CCAE:

111941733(LPL)

CCW:	104689737(LPL)

ETL:	114063704(LPL)

FPG:	101913413(LPL)

FCH:	102046454(LPL)

CLV:	102097018(LPL)

EGZ:	104123360(LPL)

NNI:	104011947(LPL)

ACUN:

113490034(LPL)

AAM:	106482500 106495445

ASN:	102368909(LPL)

AMJ:	102573889(LPL)

PSS:	102456906(LPL)

CMY:

102941095

CPIC:

101932991(LPL)

ACS:	100556298(lpl)

PVT:	110083190(LPL)

PBI:	103057093(LPL)

PMUR:

107286300(LPL)

GJA:	107118995(LPL)

XLA:	108706825(lpl.S) 108712233(lpl.L)

XTR:	100127862(lpl)

NPR:	108804916(LPL)

DRE:	100331214 101884800 30354(lpl)

SRX:	107715086 107715087 107750918 107754598 107757476

SANH:

107653621 107665504 107665505 107687910 107696683

SGH:	107552720 107561901 107561902 107588077 107588078 107596239

CCAR:

109046620 109046622 109046954 109046956 109087307 109090420

IPU:	108271131(LPL) 108280930

PHYP:

113533484 113536621 113536692

AMEX:

103021581 103042854 103043174

EEE:	113574503 113574524 113582888

TRU:	101062428(lpl) 101068642(LPL2)

TNG:	GSTEN00028798G001 GSTEN00028799G001

LCO:	104923638 104923639

NCC:	104943575 104948086

MZE:	101478316 101478598

OLA:	101160309(lpl) 101160547

XMA:	102225809 102226072

XCO:	114150801 114151199(lpl)

PRET:

103463532 103463534(lpl)

NFU:	107393172 107393174(lpl)

KMR:	108230795(lpl) 108230848

CSEM:

103397050 103397060(lpl)

LCF:	108881396 108881397(lpl)

SDU:	111232066(lpl) 111232091

HCQ:	109531926 109532054 109532313

BPEC:

110160148

MALB:

109967464

SASA:

106569629 106573544 106573546 106613694 106613695

OTW:	112224719 112250798 112250799 112252199

SALP:

111952856 111952857 111975751 111975815

ELS:	105011471 105011473(lpl) 105022495

SFM:	108919920 108919924(lpl)

PKI:	111847582 111860378 111860417

LCM:	102349247(LPL) 102362907

CMK:	103183498(lpl) 103183499

PMAC:

106717696

» show all

Reference

1 [PMID:4703566]

Authors

Egelrud T, Olivecrona T.

Title

Purified bovine milk (lipoprotein) lipase: activity against lipid substrates in the absence of exogenous serum factors.

Journal

Biochim Biophys Acta 306:115-27 (1973)
DOI:10.1016/0005-2760(73)90215-4

Reference

2 [PMID:5441398]

Authors

Fielding CJ.

Title

Human lipoprotein lipase. I. Purification and substrate specificity.

Journal

Biochim Biophys Acta 206:109-17 (1970)
DOI:10.1016/0005-2744(70)90087-2

Reference

3 [PMID:5466051]

Authors

Greten H, Levy RI, Fales H, Fredrickson DS.

Title

Hydrolysis of diglyceride and glyceryl monoester diethers with "lipoprotein lipase".

Journal

Biochim Biophys Acta 210:39-45 (1970)
DOI:10.1016/0005-2760(70)90059-7

Reference

4 [PMID:5076762]

Authors

Morley N, Kuksis A.

Title

Positional specificity of lipoprotein lipase.

Journal

J Biol Chem 247:6389-93 (1972)

Reference

5 [PMID:5168777]

Authors

Nilsson-Ehle P, Belfrage P, Borgstrom B.

Title

Purified human lipoprotein lipase: positional specificity.

Journal

Biochim Biophys Acta 248:114-20 (1971)
DOI:10.1016/0005-2760(71)90081-6

Other DBs

ExplorEnz - The Enzyme Database:

3.1.1.34

IUBMB Enzyme Nomenclature:

3.1.1.34

ExPASy - ENZYME nomenclature database:

3.1.1.34

BRENDA, the Enzyme Database:

3.1.1.34

CAS:

9004-02-8

LinkDB

DBGET integrated database retrieval system