| Entry |
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| Name |
(3S)-malyl-CoA thioesterase;
mcl2 (gene name)
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| Class |
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
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| Sysname |
(S)-malyl-CoA hydrolase
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| Reaction(IUBMB) |
(S)-malyl-CoA + H2O = (S)-malate + CoA [RN: R10612]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Stimulated by Mg2+ or Mn2+. The enzyme has no activity with (2R,3S)-2-methylmalyl-CoA (cf. EC 4.1.3.24, malyl-CoA lyase) or other CoA esters.
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| History |
EC 3.1.2.30 created 2014
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| Pathway |
| ec00630 | Glyoxylate and dicarboxylate metabolism |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K14451 | (3S)-malyl-CoA thioesterase |
| K19282 | bifunctional (S)-malyl-CoA lyase/thioesterase |
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| Genes |
» show all
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| Reference |
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| Authors |
Erb TJ, Frerichs-Revermann L, Fuchs G, Alber BE |
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| Title |
The apparent malate synthase activity of Rhodobacter sphaeroides is due to two paralogous enzymes, (3S)-Malyl-coenzyme A (CoA)/{beta}-methylmalyl-CoA lyase and (3S)- Malyl-CoA thioesterase. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.1.2.30 |
| ExPASy - ENZYME nomenclature database: | 3.1.2.30 |
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| LinkDB |
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