Entry |
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Name |
sphingomyelin phosphodiesterase;
neutral sphingomyelinase
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Class |
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
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Sysname |
sphingomyelin cholinephosphohydrolase
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Reaction(IUBMB) |
a sphingomyelin + H2O = a ceramide + phosphocholine [RN: R02541]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
Has very little activity on phosphatidylcholine.
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History |
EC 3.1.4.12 created 1972
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Pathway |
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Orthology |
K01117 | sphingomyelin phosphodiesterase |
K12350 | sphingomyelin phosphodiesterase |
K12351 | sphingomyelin phosphodiesterase 2 |
K12352 | sphingomyelin phosphodiesterase 3 |
K12353 | sphingomyelin phosphodiesterase 4 |
K12354 | ectonucleotide pyrophosphatase/phosphodiesterase family member 7 |
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Genes |
» show all
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Reference |
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Authors |
Barnholz Y, Roitman A, Gatt S. |
Title |
Enzymatic hydrolysis of sphingolipids. II. Hydrolysis of sphingomyelin by an enzyme from rat brain. |
Journal |
J Biol Chem 241:3731-7 (1966) |
Reference |
|
Authors |
Chatterjee S, Ghosh N. |
Title |
Neutral sphingomyelinase from human urine. Purification and preparation of monospecific antibodies. |
Journal |
J Biol Chem 264:12554-61 (1989) |
Reference |
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Authors |
Heller M, Shapiro B. |
Title |
Enzymic hydrolysis of sphingomyelin by rat liver. |
Journal |
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Reference |
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Authors |
Kanfer JN, Young OM, Shapiro D, Brady RO. |
Title |
The metabolism of sphingomyelin. I. Purification and properties of a sphingomyelin-cleaving enzyme from rat liver tissue. |
Journal |
J Biol Chem 241:1081-4 (1966) |
Other DBs |
ExplorEnz - The Enzyme Database: | 3.1.4.12 |
ExPASy - ENZYME nomenclature database: | 3.1.4.12 |
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LinkDB |
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