KEGG   ENZYME: 3.1.4.56Help
Entry
EC 3.1.4.56                 Enzyme                                 

Name
7,8-dihydroneopterin 2',3'-cyclic phosphate phosphodiesterase;
MptB
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
BRITE hierarchy
Sysname
7,8-dihydroneopterin 2',3'-cyclic phosphate 2'/3'-phosphodiesterase
Reaction(IUBMB)
(1) 7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 3'-phosphate [RN:R10344];
(2) 7,8-dihydroneopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 2'-phosphate [RN:R10345]
Reaction(KEGG)
Substrate
7,8-dihydroneopterin 2',3'-cyclic phosphate [CPD:C20567];
H2O [CPD:C00001]
Product
7,8-dihydroneopterin 3'-phosphate [CPD:C05925];
7,8-dihydroneopterin 2'-phosphate [CPD:C20566]
Comment
Contains one zinc atom and one iron atom per subunit of the dodecameric enzyme. It hydrolyses 7,8-dihydroneopterin 2',3'-cyclic phosphate, a step in tetrahydromethanopterin biosynthesis. In vitro the enzyme forms 7,8-dihydroneopterin 2'-phosphate and 7,8-dihydroneopterin 3'-phosphate at a ratio of 4:1.
History
EC 3.1.4.56 created 2013
Pathway
ec00790  Folate biosynthesis
ec01100  Metabolic pathways
Orthology
K17487  7,8-dihydroneopterin 2',3'-cyclic phosphate phosphodiesterase
Genes
MJA: MJ_0837
MFE: Mefer_0929
MVU: Metvu_0138
MFS: MFS40622_1324
MIF: Metin_0047
MJH: JH146_1065
MIG: Metig_0978
MMP: MMP0230
MMQ: MmarC5_1443
MMX: MmarC6_0723
MMD: GYY_01170
MAE: Maeo_0933
MVO: Mvol_1222
MKA: MK0390
IAG: Igag_1784
HBU: Hbut_0015
BARB: AOA66_1470(mptB)
 » show all
Taxonomy
Reference
1  [PMID:19746965]
  Authors
Mashhadi Z, Xu H, White RH
  Title
An Fe2+-dependent cyclic phosphodiesterase catalyzes the hydrolysis of 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate in methanopterin biosynthesis.
  Journal
Biochemistry 48:9384-92 (2009)
DOI:10.1021/bi9010336
  Sequence
[mja:MJ_0837]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.4.56
IUBMB Enzyme Nomenclature: 3.1.4.56
ExPASy - ENZYME nomenclature database: 3.1.4.56
BRENDA, the Enzyme Database: 3.1.4.56
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