| Entry |
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| Name |
N-acetylglucosamine-6-sulfatase;
chondroitinsulfatase;
O,N-disulfate O-sulfohydrolase;
acetylglucosamine 6-sulfatase;
N-acetylglucosamine 6-sulfate sulfatase;
acetylglucosamine 6-sulfatase;
2-acetamido-2-deoxy-D-glucose 6-sulfate sulfatase
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| Class |
Hydrolases;
Acting on ester bonds;
Sulfuric-ester hydrolases
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| Sysname |
N-acetyl-D-glucosamine-6-sulfate 6-sulfohydrolase
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| Reaction(IUBMB) |
Hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate [RN: R07808 R07819]
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| Reaction(KEGG) |
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| Comment |
May be identical with EC 3.1.6.11 disulfoglucosamine-6-sulfatase.
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| History |
EC 3.1.6.14 created 1984
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| Pathway |
| ec00531 | Glycosaminoglycan degradation |
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| Orthology |
| K01137 | N-acetylglucosamine-6-sulfatase |
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| Genes |
» show all
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| Reference |
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| Authors |
Basner R, Kresse H, von Figura K. |
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| Title |
N-Acetylglucosamine-6-sulfate sulfatase from human urine. |
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| Journal |
J Biol Chem 254:1151-8 (1979) |
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| Reference |
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| Authors |
Kresse H, Fuchs W, Glossl J, Holtfrerich D, Gilberg W. |
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| Title |
Liberation of N-acetylglucosamine-6-sulfate by human beta-N-acetylhexosaminidase A. |
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| Journal |
J Biol Chem 256:12926-32 (1981) |
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| Reference |
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| Authors |
Weissmann B, Chao H, Chow P. |
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| Title |
A glucosamine O,N-disulfate O-sulfohydrolase with a probable role in mammalian catabolism of heparan sulfate. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.1.6.14 |
| ExPASy - ENZYME nomenclature database: | 3.1.6.14 |
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| LinkDB |
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