EC 220.127.116.11 Enzyme
ribosomal ribonucleate N-glycosidase;
Mirabilis antiviral protein;
Hydrolysing N-glycosyl compounds
Hydrolysis of the N-glycosylic bond at A-4324 in 28S rRNA from rat ribosomes
Ricin A-chain and related toxins show this activity. Naked rRNA is attacked more slowly than rRNA in intact ribosomes. Naked rRNA from Escherichia coli is cleaved at a corresponding position.
EC 18.104.22.168 created 1990, modified 2000
Endo Y, Tsurugi K.
The RNA N-glycosidase activity of ricin A-chain. The characteristics of the enzymatic activity of ricin A-chain with ribosomes and with rRNA.
J Biol Chem 263:8735-9 (1988)
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