| Entry |
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| Name |
membrane alanyl aminopeptidase;
microsomal aminopeptidase;
aminopeptidase M;
aminopeptidase N;
particle-bound aminopeptidase;
amino-oligopeptidase;
alanine aminopeptidase;
membrane aminopeptidase I;
pseudo leucine aminopeptidase;
alanyl aminopeptidase;
alanine-specific aminopeptidase;
cysteinylglycine dipeptidase;
cysteinylglycinase;
L-alanine aminopeptidase;
CD13
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Aminopeptidases
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| Reaction(IUBMB) |
Release of an N-terminal amino acid, Xaa!Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide
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| Reaction(KEGG) |
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| Comment |
A zinc enzyme, not activated by heavy metal ions. Type example of peptidase family M1.
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| History |
EC 3.4.11.2 created 1961 as EC 3.4.1.2, transferred 1972 to EC 3.4.11.2 (EC 3.4.13.6 created 1961 as EC 3.4.3.5, transferred 1972 to EC 3.4.13.6, incorporated 1997)
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| Pathway |
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| Orthology |
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| Genes |
» show all
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| Reference |
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| Authors |
Wachsmuth ED, Fritze I, Pfleiderer G. |
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| Title |
An aminopeptidase occurring in pig kidney. I. An improved method of preparation. Physical and enzymic properties. |
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| Journal |
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| Reference |
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| Authors |
Kim YS, Brophy EJ. |
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| Title |
Rat intestinal brush border membrane peptidases. I. Solubilization, purification, and physicochemical properties of two different forms of the enzyme. |
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| Journal |
J Biol Chem 251:3199-205 (1976) |
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| Reference |
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| Authors |
Gray GM, Santiago NA. |
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| Title |
Intestinal surface amino-oligopeptidases. I. Isolation of two weight isomers and their subunits from rat brush border. |
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| Journal |
J Biol Chem 252:4922-8 (1977) |
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| Reference |
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| Authors |
Sjostrom H, Noren O, Jeppesen L, Staun M, Svensson B, Christiansen L. |
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| Title |
Purification of different amphiphilic forms of a microvillus aminopeptidase from pig small intestine using immunoadsorbent chromatography. |
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| Journal |
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| Reference |
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| Authors |
Feracci H, Maroux S. |
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| Title |
Rabbit intestinal aminopeptidase N. Purification and molecular properties. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.4.11.2 |
| ExPASy - ENZYME nomenclature database: | 3.4.11.2 |
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| LinkDB |
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