KEGG   ENZYME: 3.4.14.13Help
Entry
EC 3.4.14.13                Enzyme                                 

Name
gamma-D-glutamyl-L-lysine dipeptidyl-peptidase;
YkfC
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidyl-peptidases and tripeptidyl-peptidases
BRITE hierarchy
Reaction(IUBMB)
The enzyme releases L-Ala-gamma-D-Glu dipeptides from cell wall peptides via cleavage of an L-Ala-gamma-D-Glu!L-Lys bond. [RN:R11190]
Reaction(KEGG)
Comment
The enzyme, characterized from the bacterium Bacillus subtilis, is involved in the recycling of the murein peptide.
History
EC 3.4.14.13 created 2015
Orthology
K20742  gamma-D-glutamyl-L-lysine dipeptidyl-peptidase
Genes
BSU: BSU12990(ykfC)
BSR: I33_1462
BSL: A7A1_1443
BSH: BSU6051_12990(ykfC)
BSY: I653_06655
BSUT: BSUB_01416(ykfC)
BSUL: BSUA_01416(ykfC)
BSUS: Q433_07425
BSS: BSUW23_06655(ykfC)
BST: GYO_1618
BSO: BSNT_07784(ykfC)
BSQ: B657_12990(ykfC)
BSX: C663_1337
BLI: BL03764(ykfC)
BLD: BLi01399(ykfC)
BLH: BaLi_c15400(ykfC)
BAQ: BACAU_1261(ykfC)
BYA: BANAU_1220(ykfC)
BAMP: B938_06665
BAML: BAM5036_1218(ykfC)
BAMA: RBAU_1261(ykfC)
BAMN: BASU_1240(ykfC)
BAMB: BAPNAU_2482(ykfC)
BAMT: AJ82_07355
BAMY: V529_12320(ykfC)
BMP: NG74_01331(ykfC)
BAO: BAMF_1387(ykfC)
BAZ: BAMTA208_10630(ykfC)
BQL: LL3_01401(ykfC)
BXH: BAXH7_02174(ykfC)
BAMI: KSO_012965
BAMC: U471_12980
BAMF: U722_06855
BHA: BH3007
BAN: BA_2849
BAR: GBAA_2849
BAT: BAS2658
BAI: BAA_2911
BANT: A16_28820
BANR: A16R_29250
BANS: BAPAT_2738
BANV: DJ46_1623(ykfC)
BCE: BC2849
BCA: BCE_2878
BCQ: BCQ_2686
BCX: BCA_2930
BNC: BCN_2709
BCF: bcf_13940
BCER: BCK_20625
BTL: BALH_2557
BTT: HD73_3130
BTHI: BTK_15525
BTM: MC28_2038
BTG: BTB_c29690(ykfC)
BTI: BTG_05100
BTW: BF38_4017(ykfC)
BWW: bwei_2181(ykfC)
BMYO: BG05_3175
BMYC: DJ92_5319(ykfC)
BCL: ABC0782
BPU: BPUM_1191
BPUM: BW16_06770
BPUS: UP12_06310
BPF: BpOF4_12075(ykfC)
BMEG: BG04_2761 BG04_3771(ykfC)
BCK: BCO26_2254(ykfC)
BAG: Bcoa_2197
BCOA: BF29_1382(ykfC)
BJS: MY9_1424
BMET: BMMGA3_08805(ykfC)
BACW: QR42_06165
BACP: SB24_03285
BACB: OY17_09520
BACY: QF06_05510
BACL: BS34A_14380(ykfC)
BALM: BsLM_1373
BEO: BEH_02635
BGY: BGLY_1392
OIH: OB2964
GTN: GTNG_3182
HLI: HLI_15400
VPN: A21D_00920(ykfC)
PSYO: PB01_20045
LIN: lin0198
LWE: lwe0136
LSG: lse_0139
LIV: LIV_0129
BBE: BBR47_01650(ykfC)
SIV: SSIL_0333
JEO: JMA_32900
LPL: lp_2520
LPJ: JDM1_2029
LPZ: Lp16_2002
LBR: LVIS_1419
LBH: Lbuc_1248
ECAS: ECBG_02907
CRN: CAR_c00610(ykfC)
CARC: NY10_1815
HSC: HVS_00210(ykfC)
PTH: PTH_2675
TMR: Tmar_1703
PFT: JBW_03658
MANA: MAMMFC1_02901(ykfC)
SLX: SLAV_01950(ykfC)
LMOI: VV02_14500
BLIN: BLSMQ_3306
KFL: Kfla_3115
PSEA: WY02_28255
PSEE: FRP1_14455
PSEH: XF36_14700
PAUT: Pdca_27110
SNA: Snas_3326
PNL: PNK_0299
CEX: CSE_02890
 » show all
Taxonomy
Reference
1  [PMID:11747447]
  Authors
Schmidt DM, Hubbard BK, Gerlt JA
  Title
Evolution of enzymatic activities in the enolase superfamily: functional assignment of unknown proteins in Bacillus subtilis and Escherichia coli as L-Ala-D/L-Glu epimerases.
  Journal
Biochemistry 40:15707-15 (2001)
DOI:10.1021/bi011640x
  Sequence
[bsu:BSU12990]
Reference
2  [PMID:20944232]
  Authors
Xu Q, Abdubek P, Astakhova T, Axelrod HL, Bakolitsa C, Cai X, Carlton D, Chen C, Chiu HJ, Chiu M, Clayton T, Das D, Deller MC, Duan L, Ellrott K, Farr CL, Feuerhelm J, Grant JC, Grzechnik A, Han GW, Jaroszewski L, Jin KK, Klock HE, Knuth MW, Kozbial P, Krishna SS, Kumar A, Lam WW, Marciano D, Miller MD, Morse AT, Nigoghossian E, Nopakun A, Okach L, Puckett C, Reyes R, Tien HJ, Trame CB, van den Bedem H, Weekes D, Wooten T, Yeh A, Hodgson KO, Wooley J, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Wilson IA
  Title
Structure of the gamma-D-glutamyl-L-diamino acid endopeptidase YkfC from Bacillus cereus in complex with L-Ala-gamma-D-Glu: insights into substrate recognition by  NlpC/P60 cysteine peptidases.
  Journal
Acta Crystallogr Sect F Struct Biol Cryst Commun 66:1354-64 (2010)
DOI:10.1107/S1744309110021214
  Sequence
[bca:BCE_2878]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.14.13
IUBMB Enzyme Nomenclature: 3.4.14.13
ExPASy - ENZYME nomenclature database: 3.4.14.13
BRENDA, the Enzyme Database: 3.4.14.13
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