| Entry |
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| Name |
carboxypeptidase E;
carboxypeptidase H;
enkephalin convertase;
cobalt-stimulated chromaffin granule carboxypeptidase;
insulin granule-associated carboxypeptidase;
enkephalin convertase;
membrane-bound carboxypeptidase;
carboxypeptidase E;
enkephalin-precursor endopeptidase;
enkephalin precursor carboxypeptidase;
peptidyl-L-lysine(-L-arginine) hydrolase
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
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| Reaction(IUBMB) |
Release of C-terminal arginine or lysine residues from polypeptides
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| Comment |
A zinc enzyme, activated by Co2+. Inhibited by 1,10-phenanthroline and other chelating agents. pH optimum 5.6. Located in storage granules of secretory cells, and active in processing of protein hormones and bioactive peptides. In peptidase family M14 (carboxypeptidase A family).
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| History |
EC 3.4.17.10 created 1986, modified 2000
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| Orthology |
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| Genes |
» show all
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| Reference |
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| Authors |
Qian Y, Varlamov O, Fricker LD. |
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| Title |
Glu300 of rat carboxypeptidase E is essential for enzymatic activity but not substrate binding or routing to the regulated secretory pathway. |
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| Journal |
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| Reference |
2 |
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| Authors |
Fricker, L.D. |
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| Title |
Carboxypeptidase E/H. |
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| Journal |
In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, Academic Press, London, 1998, p. 1341-1344. |
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| Reference |
3 |
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| Authors |
Fricker, L.D. |
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| Title |
Methods for studying carboxypeptidase E. |
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| Journal |
Methods Neurosci 23:237-250 (1995) |
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| Reference |
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| Authors |
Manser E, Fernandez D, Loo L, Goh PY, Monfries C, Hall C, Lim L. |
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| Title |
Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Fricker LD. |
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| Title |
Carboxypeptidase E. |
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| Journal |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 3.4.17.10 |
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| LinkDB |
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