Entry |
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Name |
tubulin-glutamate carboxypeptidase;
cytosolic carboxypeptidase 1;
cytosolic carboxypeptidase 5;
CCP1;
CCP5;
Agtpbp1 (gene name);
AGBL5 (gene name)
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Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
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Reaction(IUBMB) |
This is a subfamily of enzymes that cleave C-terminal and/or side chain amino acids from tubulins. The dual-specificity enzymes can cleave both alpha- and gamma-linked L-glutamate from tubulins, removing the posttranslationally added polyglutamyl side chains from the C-terminal regions. In addition, the enzyme removes two glutamate residues from the C-terminus of beta-tubulin and detyrosinated alpha-tubulin (from which the C-terminal L-tyrosine has been removed by EC 3.4.17.17, tubulinyl-Tyr carboxypeptidase). The latter is cleaved to delta2-tubulin and further to delta3-tubulin.
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History |
EC 3.4.17.24 created 2020
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Orthology |
K23435 | cytosolic carboxypeptidase protein 1 |
K23436 | cytosolic carboxypeptidase protein 4 |
K23438 | cytosolic carboxypeptidase protein 5 |
K23439 | cytosolic carboxypeptidase protein 6 |
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Genes |
» show all
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Reference |
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Authors |
Rogowski K, van Dijk J, Magiera MM, Bosc C, Deloulme JC, Bosson A, Peris L, Gold ND, Lacroix B, Bosch Grau M, Bec N, Larroque C, Desagher S, Holzer M, Andrieux A, Moutin MJ, Janke C |
Title |
A family of protein-deglutamylating enzymes associated with neurodegeneration. |
Journal |
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Sequence |
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Reference |
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Authors |
Kimura Y, Kurabe N, Ikegami K, Tsutsumi K, Konishi Y, Kaplan OI, Kunitomo H, Iino Y, Blacque OE, Setou M |
Title |
Identification of tubulin deglutamylase among Caenorhabditis elegans and mammalian cytosolic carboxypeptidases (CCPs). |
Journal |
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Sequence |
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Reference |
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Authors |
Berezniuk I, Vu HT, Lyons PJ, Sironi JJ, Xiao H, Burd B, Setou M, Angeletti RH, Ikegami K, Fricker LD |
Title |
Cytosolic carboxypeptidase 1 is involved in processing alpha- and beta-tubulin. |
Journal |
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Reference |
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Authors |
Berezniuk I, Lyons PJ, Sironi JJ, Xiao H, Setou M, Angeletti RH, Ikegami K, Fricker LD |
Title |
Cytosolic carboxypeptidase 5 removes alpha- and gamma-linked glutamates from tubulin. |
Journal |
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Reference |
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Authors |
Pathak N, Austin-Tse CA, Liu Y, Vasilyev A, Drummond IA |
Title |
Cytoplasmic carboxypeptidase 5 regulates tubulin glutamylation and zebrafish cilia formation and function. |
Journal |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 3.4.17.24 |
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LinkDB |
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