KEGG   ENZYME: 3.5.1.101
Entry
EC 3.5.1.101                Enzyme                                 

Name
L-proline amide hydrolase;
S-stereoselective piperazine-2-tert-butylcarboxamide hydrolase;
LaaA;
L-amino acid amidase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
Sysname
(S)-piperidine-2-carboxamide amidohydrolase
Reaction(IUBMB)
(1) (S)-piperidine-2-carboxamide + H2O = (S)-piperidine-2-carboxylate + NH3 [RN:R09680];
(2) L-prolinamide + H2O = L-proline + NH3 [RN:R09650]
Reaction(KEGG)
R09650 R09680;
(other) R09649
Substrate
(S)-piperidine-2-carboxamide [CPD:C19809];
H2O [CPD:C00001];
L-prolinamide [CPD:C19781]
Product
(S)-piperidine-2-carboxylate;
NH3 [CPD:C00014];
L-proline [CPD:C00148]
History
EC 3.5.1.101 created 2009
Orthology
K18457  L-proline amide hydrolase
Genes
ENR: H650_21365
ENF: AKI40_3759
KOX: KOX_25325
KOE: A225_3919
KOY: J415_12255
KOM: HR38_23405
KOK: KONIH1_19640
KOC: AB185_16635
KLL: BJF97_19530
KLW: DA718_09620
RTG: NCTC13098_04863(laaA_1)
REE: electrica_01634(laaA)
RAA: Q7S_23546
DDQ: DDI_1138
XCC: XCC2817
XCB: XC_1296
XCA: xcc-b100_1343(pip2)
XCP: XCR_3189
XCV: XCV3134(pip)
XAX: XACM_2921(pip)
XAC: XAC2987
XCI: XCAW_03265(mhpC)
XOM: XOO1168(XOO1168)
XOO: XOO1269(MhpC)
XOP: PXO_02210
XOR: XOC_1423
XPH: XppCFBP6546_20825(XppCFBP6546P_20825)
PSB: Psyr_4217
PVD: CFBP1590__4609(laaA)
PFL: PFL_5297(pip)
PPRC: PFLCHA0_c52700(laaA)
PPRO: PPC_5275(pip)
PFS: PFLU_1629
PFC: PflA506_1682(pip)
PFB: VO64_4751
PFW: PF1751_v1c15970(laaA)
PSEC: CCOS191_2563(laaA)
PANR: A7J50_1787
GNI: GNIT_0098(pip)
AAA: Acav_2489
MLO: mll0601
MHUA: MCHK_2307
SME: SMc04031(pip2)
SMX: SM11_chr2980(pip2)
SMI: BN406_02672(laaA)
SMEL: SM2011_c04031(pip2)
SMER: DU99_15550
SIX: BSY16_462
ARA: Arad_8444(pipb1)
AVI: Avi_5637
RET: RHE_PB00088(pipb1)
REC: RHECIAT_PC0000238(pipc2)
REL: REMIM1_PA00099(laaA)
REP: IE4803_PD00432(laaA)
REI: IE4771_PE00449(laaA)
RLE: pRL90179(pip)
RLG: Rleg_6197
RHL: LPU83_pLPU83d1219(laaA)
RGA: RGR602_PC00694(laaA)
RPHA: AMC79_PD00249(laaA)
RHK: Kim5_PD00408(laaA)
OCH: CES85_4734(laaA)
PLEO: OHA_1_01329(laaA)
HDI: HDIA_0226(laaA)
RCP: RCAP_rcc01087(pip2)
SPKC: KC8_00275
SSY: SLG_35840
SMIC: SmB9_08520
GXL: H845_766
RRU: Rru_A2180
RRF: F11_11230
CPY: Cphy_0973
MAO: MAP4_3180
MAVI: RC58_15760
MAVU: RE97_15790
MAV: MAV_0868
MIT: OCO_07220
MIA: OCU_07230
MID: MIP_01253
MYO: OEM_07290
MIR: OCQ_07370
MUL: MUL_0358(pip)
MMAE: MMARE11_46190(pip)
MMM: W7S_03530
MLI: MULP_05019(pip)
MHAD: B586_01120
CVA: CVAR_1950(pepI)
SFA: Sfla_0992
SHY: SHJG_1916
STRP: F750_5856
SRW: TUE45_pSRc_0416(laaA)
SALJ: SMD11_1692(pip)
SGE: DWG14_07620(laaA)
MTS: MTES_2595
SRO: Sros_2123
KRA: Krad_0552
AMYY: YIM_11610(laaA)
AMI: Amir_2685
KAL: KALB_1476
ASE: ACPL_6077(pip2)
ACTS: ACWT_5945
 » show all
Reference
1  [PMID:15066172]
  Authors
Komeda H, Harada H, Washika S, Sakamoto T, Ueda M, Asano Y
  Title
S-stereoselective piperazine-2-tert-butylcarboxamide hydrolase from Pseudomonas azotoformans IAM 1603 is a novel L-amino acid amidase.
  Journal
Eur J Biochem 271:1465-75 (2004)
DOI:10.1111/j.1432-1033.2004.04056.x
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.101
IUBMB Enzyme Nomenclature: 3.5.1.101
ExPASy - ENZYME nomenclature database: 3.5.1.101
BRENDA, the Enzyme Database: 3.5.1.101
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