| Entry |
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| Name |
(S)-ureidoglycine aminohydrolase;
UGlyAH;
UGHY;
ylbA (gene name)
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| Class |
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amidines
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| Sysname |
(S)-ureidoglycine aminohydrolase
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| Reaction(IUBMB) |
(S)-2-ureidoglycine + H2O = (S)-ureidoglycolate + NH3 [RN: R05554]
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| Reaction(KEGG) |
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| Substrate |
(S)-2-ureidoglycine;
H2O [CPD: C00001]
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| Product |
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| Comment |
Binds Mn2+. This enzyme, found in plants and bacteria, is part of the ureide pathway, which enables the recycling of the nitrogen in purine compounds. In plants it is localized in the endoplasmic reticulum.
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| History |
EC 3.5.3.26 created 2013
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| Pathway |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K14977 | (S)-ureidoglycine aminohydrolase |
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| Genes |
» show all
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| Reference |
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| Authors |
Serventi F, Ramazzina I, Lamberto I, Puggioni V, Gatti R, Percudani R |
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| Title |
Chemical basis of nitrogen recovery through the ureide pathway: formation and hydrolysis of S-ureidoglycine in plants and bacteria. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Werner AK, Romeis T, Witte CP |
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| Title |
Ureide catabolism in Arabidopsis thaliana and Escherichia coli. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Shin I, Percudani R, Rhee S |
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| Title |
Structural and functional insights into (S)-ureidoglycine aminohydrolase, key enzyme of purine catabolism in Arabidopsis thaliana. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.5.3.26 |
| ExPASy - ENZYME nomenclature database: | 3.5.3.26 |
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| LinkDB |
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