KEGG   ENZYME: 3.5.4.34Help
Entry
EC 3.5.4.34                 Enzyme                                 

Name
tRNAAla(adenine37) deaminase;
ADAT1;
Tad1p
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
BRITE hierarchy
Sysname
tRNAAla(adenine37) aminohydrolase
Reaction(IUBMB)
adenine37 in tRNAAla + H2O = hypoxanthine37 in tRNAAla + NH3 [RN:R10231]
Reaction(KEGG)
Substrate
adenine37 in tRNAAla;
H2O [CPD:C00001]
Product
hypoxanthine37 in tRNAAla;
NH3 [CPD:C00014]
Comment
The enzyme deaminates adenosine37 to inosine in eukaryotic tRNAAla [1]. tRNA editing is strictly dependent on Mg2+ [2].
History
EC 3.5.4.34 created 2013
Orthology
K15440  tRNA-specific adenosine deaminase 1
Genes
HSA: 23536(ADAT1)
PTR: 468030(ADAT1)
PPS: 100981842(ADAT1)
GGO: 101139542(ADAT1)
PON: 100439664(ADAT1)
NLE: 100606616(ADAT1)
MCC: 712066(ADAT1)
MCF: 101925428(ADAT1)
CSAB: 103233319(ADAT1)
RRO: 104677849(ADAT1)
RBB: 108527413(ADAT1)
CJC: 100404128(ADAT1)
SBQ: 101053316(ADAT1)
MMU: 30947(Adat1)
MCAL: 110300092(Adat1)
MPAH: 110337640(Adat1)
RNO: 690810(Adat1)
MUN: 110554746(Adat1)
CGE: 100767121(Adat1)
NGI: 103725659(Adat1)
HGL: 101705855(Adat1)
CCAN: 109700198(Adat1)
OCU: 100343387(ADAT1)
TUP: 102499762(ADAT1)
CFA: 489706(ADAT1)
VVP: 112915675(ADAT1)
AML: 100479698(ADAT1)
UMR: 103662068(ADAT1)
UAH: 113252505(ADAT1)
ORO: 101368871(ADAT1)
FCA: 101092319(ADAT1)
PTG: 102955523(ADAT1)
PPAD: 109245684(ADAT1)
AJU: 106983436(ADAT1)
BTA: 618521(ADAT1)
BOM: 102264752(ADAT1)
BIU: 109572141(ADAT1)
BBUB: 102396811(ADAT1)
CHX: 102176155(ADAT1)
OAS: 101118042(ADAT1)
SSC: 100521793(ADAT1)
CFR: 102523223(ADAT1)
CDK: 105084368(ADAT1)
BACU: 102997798(ADAT1)
LVE: 103075475(ADAT1)
OOR: 101288323(ADAT1)
DLE: 111179499(ADAT1)
PCAD: 102992688(ADAT1)
ECB: 100069032(ADAT1)
EPZ: 103553030(ADAT1)
EAI: 106835140(ADAT1)
MYB: 102245792(ADAT1)
MYD: 102773961(ADAT1)
MNA: 107524732(ADAT1)
HAI: 109384786(ADAT1)
DRO: 112300653(ADAT1)
PALE: 102895391(ADAT1)
RAY: 107502661(ADAT1)
MJV: 108385747(ADAT1)
LAV: 100673891(ADAT1)
TMU: 101348133
MDO: 100021062(ADAT1)
SHR: 100931012(ADAT1) 105750451
PCW: 110192403(ADAT1)
OAA: 100077425(ADAT1)
GGA: 415886(ADAT1)
MGP: 100551118(ADAT1)
CJO: 107319473(ADAT1)
NMEL: 110404458(ADAT1)
APLA: 101805235(ADAT1)
ACYG: 106046625(ADAT1)
TGU: 100218982(ADAT1)
LSR: 110468744(ADAT1)
SCAN: 103816784(ADAT1)
GFR: 102032012(ADAT1)
FAB: 101814233(ADAT1)
PHI: 102107809(ADAT1)
PMAJ: 107209777(ADAT1)
CCAE: 111934369(ADAT1)
CCW: 104691867(ADAT1)
ETL: 114067457(ADAT1)
FPG: 101910523(ADAT1)
FCH: 102058985(ADAT1)
CLV: 102084029(ADAT1)
EGZ: 104126302(ADAT1)
NNI: 104023547(ADAT1)
ACUN: 113484610(ADAT1)
PADL: 103916510(ADAT1)
AAM: 106498820(ADAT1)
ASN: 102368236(ADAT1)
AMJ: 102571449(ADAT1)
PSS: 102448082(ADAT1)
CMY: 102946863(ADAT1)
CPIC: 101939226(ADAT1)
ACS: 100561591(adat1)
PVT: 110076236(ADAT1)
PMUR: 107283504(ADAT1)
TSR: 106539676(ADAT1)
PMUA: 114602044(ADAT1)
GJA: 107124717(ADAT1)
XLA: 108715443(adat1.S)
XTR: 733776(adat1)
NPR: 108786552(ADAT1)
DRE: 792614(adat1)
SRX: 107740251(adat1)
SANH: 107667671 107695929(adat1)
SGH: 107555735
CCAR: 109050808(adat1)
IPU: 108268589(adat1)
PHYP: 113541905(adat1)
AMEX: 103040099(adat1)
EEE: 113568338(adat1)
TRU: 101074345(adat1)
LCO: 104933814(adat1)
NCC: 104942841(adat1)
MZE: 101472193
ONL: 100705296(adat1)
OLA: 101174830(adat1)
XMA: 102227749(adat1)
XCO: 114150263(adat1)
PRET: 103466300(adat1)
CVG: 107099695(adat1)
NFU: 107389276(adat1)
KMR: 108246578(adat1)
ALIM: 106536367(adat1)
AOCE: 111568878(adat1)
CSEM: 103379688(adat1)
POV: 109646081(adat1)
LCF: 108901943(adat1)
SDU: 111238843(adat1)
SLAL: 111647716(adat1)
HCQ: 109513086(adat1)
BPEC: 110169227(adat1)
MALB: 109952540(adat1)
SASA: 106560904(adat1)
OTW: 112218467(adat1)
SALP: 111962303(adat1)
ELS: 105018553(adat1)
SFM: 108926551(adat1)
PKI: 111851951
CMK: 103175977(adat1)
RTP: 109921629(adat1)
CIN: 100182358
APLC: 110984767
SKO: 102806186
DME: Dmel_CG16889(Adat1)
DER: 6540900
DSI: Dsimw501_GD22044(Dsim_GD22044)
DSR: 110185656
DPE: 6598039
DAZ: 108611532
DNV: 108658176
DHE: 111594671
MDE: 101900436
LCQ: 111682562
AALB: 109622813
AME: 551302
BIM: 100748498
BTER: 100642445
CCAL: 108624178
OBB: 114878209
SOC: 105194728
MPHA: 105837029
AEC: 105152138
ACEP: 105625133
PBAR: 105425530
VEM: 105569316
HST: 105185510
DQU: 106746248
CFO: 105256150
LHU: 105678875
PGC: 109863573
OBO: 105281171
PCF: 106788639
NVI: 100121124
CSOL: 105363747
MDL: 103576482
TCA: 655593
DPA: 109534526
ATD: 109596597
NVL: 108559961
BMOR: 101739192
PMAC: 106720662
PRAP: 110996958
HAW: 110384029
API: 100568554
DNX: 107166552
AGS: 114120922
RMD: 113552320
BTAB: 109038158
CLEC: 106661828
ZNE: 110836219
FCD: 110842127
TUT: 107361104
DPTE: 113793346
CSCU: 111631165
PTEP: 107448678
PCAN: 112577152
CRG: 105331927
MYI: 110464775
OBI: 106874675
EPA: 110233417
ADF: 107335875
PDAM: 113678039
SPIS: 111332877
DGT: 114516505
HMG: 100215148
AQU: 100631880
ATH: AT1G01760
CRB: 17897246
BRP: 103844675
BOE: 106344189
RSZ: 108807102
THJ: 104817020
CPAP: 110819598
CIT: 102615864
TCC: 18614170
GRA: 105763844
GAB: 108463002
DZI: 111304710
VRA: 106773759
VAR: 108347039
VUN: 114166262
CCAJ: 109813400
CAM: 101515616
LJA: Lj0g3v0318859.1(Lj0g3v0318859.1) Lj0g3v0318859.2(Lj0g3v0318859.2) Lj0g3v0318859.3(Lj0g3v0318859.3)
ADU: 107460113
AIP: 107621135
FVE: 101298753
RCN: 112168121
PPER: 18787066
MDM: 103456191
PXB: 103938654
ZJU: 107423564
CSV: 101204115
CMO: 103497724
MCHA: 111023070
CMAX: 111499268
CMOS: 111460170
CPEP: 111806493
RCU: 8261853
JCU: 105643009
HBR: 110644553
MESC: 110618772
POP: 7464922
JRE: 108986625
VVI: 100253329
SLY: 101259338
SPEN: 107018821
SOT: 102587689
CANN: 107870939
NSY: 104225729
NTO: 104098388
NAU: 109235195
INI: 109184458
SIND: 105174353
HAN: 110937666
LSV: 111912894
CCAV: 112526658
DCR: 108219457
NNU: 104608721
OSA: 4337445
DOSA: Os04t0683500-01(Os04g0683500)
OBR: 102700891
BDI: 100833349
ATS: 109757904(LOC109757904)
SBI: 8070264
SITA: 101783323
PDA: 103719412
EGU: 105054832
MUS: 103980686
DCT: 110099821
PEQ: 110033256
AOF: 109848180
PPP: 112280993
APRO: F751_6838
SCE: YGL243W(TAD1)
ERC: Ecym_2596
KMX: KLMA_30705(TAD1)
NCS: NCAS_0E00270(NCAS0E00270)
NDI: NDAI_0I03230(NDAI0I03230)
TPF: TPHA_0G03640(TPHA0G03640)
TBL: TBLA_0E00230(TBLA0E00230)
TDL: TDEL_0D06340(TDEL0D06340)
KAF: KAFR_0J02870(KAFR0J02870)
CAL: CAALFM_C700130WA(CaO19.7110)
SLB: AWJ20_3609(TAD1)
NCR: NCU03149
NTE: NEUTE1DRAFT126133(NEUTE1DRAFT_126133)
MGR: MGG_02712
SSCK: SPSK_03312
MAW: MAC_00878
MAJ: MAA_07368
CMT: CCM_03277
MBE: MBM_05193
ANI: AN4093.2
ANG: ANI_1_1274164(An18g03470)
ABE: ARB_05647
TVE: TRV_01215
PTE: PTT_10741
CNE: CNG03760
CNB: CNBG0980
ABP: AGABI1DRAFT73247(AGABI1DRAFT_73247)
ABV: AGABI2DRAFT202903(AGABI2DRAFT_202903)
MGL: MGL_0207
MRT: MRET_1108
DFA: DFA_02228
SPAR: SPRG_19825
 » show all
Taxonomy
Reference
1  [PMID:10430867]
  Authors
Maas S, Gerber AP, Rich A
  Title
Identification and characterization of a human tRNA-specific adenosine deaminase  related to the ADAR family of pre-mRNA editing enzymes.
  Journal
Proc Natl Acad Sci U S A 96:8895-900 (1999)
DOI:10.1073/pnas.96.16.8895
  Sequence
[hsa:23536]
Reference
2  [PMID:9707437]
  Authors
Gerber A, Grosjean H, Melcher T, Keller W
  Title
Tad1p, a yeast tRNA-specific adenosine deaminase, is related to the mammalian pre-mRNA editing enzymes ADAR1 and ADAR2.
  Journal
EMBO J 17:4780-9 (1998)
DOI:10.1093/emboj/17.16.4780
  Sequence
[sce:YGL243W]
Reference
3  [PMID:10629039]
  Authors
Keegan LP, Gerber AP, Brindle J, Leemans R, Gallo A, Keller W, O'Connell MA
  Title
The properties of a tRNA-specific adenosine deaminase from Drosophila melanogaster support an evolutionary link between pre-mRNA editing and tRNA modification.
  Journal
Mol Cell Biol 20:825-33 (2000)
DOI:10.1128/MCB.20.3.825-833.2000
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.34
IUBMB Enzyme Nomenclature: 3.5.4.34
ExPASy - ENZYME nomenclature database: 3.5.4.34
BRENDA, the Enzyme Database: 3.5.4.34
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