Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In other compounds

2-iminobutanoate aminohydrolase

(1) 2-iminobutanoate + H2O = 2-oxobutanoate + NH3 [RN:R11098];
(2) 2-iminopropanoate + H2O = pyruvate + NH3 [RN:R11099]

R11098 R11099

2-iminobutanoate [CPD:C20905];
H2O [CPD:C00001];
2-iminopropanoate [CPD:C20904]

This enzyme, which has been found in all species and tissues examined, catalyses the hydrolytic deamination of imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases, such as EC 4.3.1.19, threonine ammonia-lyase and EC 4.3.1.17, L-serine ammonia-lyase. The reactions, which can occur spontaneously, are accelerated to minimize the cellular damage that could be caused by these reactive intermediates.

EC 3.5.99.10 created 2014