KEGG   ENZYME: 3.5.99.11
Entry
EC 3.5.99.11                Enzyme                                 

Name
2-aminomuconate deaminase (2-hydroxymuconate-forming);
cnbZ (gene name)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In other compounds
Sysname
2-aminomuconate aminohydrolase [(2Z,4E)-2-hydroxyhexa-2,4-dienedioate-forming]
Reaction(IUBMB)
2-aminomuconate + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH3
Reaction(KEGG)
(other) R11532
Substrate
2-aminomuconate [CPD:C02220];
H2O [CPD:C00001]
Product
(2Z,4E)-2-hydroxyhexa-2,4-dienedioate;
NH3 [CPD:C00014]
Comment
The enzyme, characterized from the bacterium Comamonas testosteroni CNB-1, converts 2-aminomuconate to 2-hydroxyhexa-2,4-dienedioate, unlike the enzymes from Pseudomonas, which produce (3E)-2-oxohex-3-enedioate (see EC 3.5.99.5, 2-aminomuconate deaminase). The enzyme also acts on 2-amino-5-chloromuconate.
History
EC 3.5.99.11 created 2016 as EC 3.5.1.120, transferred 2017 to EC 3.5.99.11
Orthology
K20931  2-aminomuconate deaminase (2-hydroxymuconate-forming)
Reference
1  [PMID:17259310]
  Authors
Liu L, Wu JF, Ma YF, Wang SY, Zhao GP, Liu SJ
  Title
A novel deaminase involved in chloronitrobenzene and nitrobenzene degradation with Comamonas sp. strain CNB-1.
  Journal
J Bacteriol 189:2677-82 (2007)
DOI:10.1128/JB.01762-06
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.5.99.11
IUBMB Enzyme Nomenclature: 3.5.99.11
ExPASy - ENZYME nomenclature database: 3.5.99.11
BRENDA, the Enzyme Database: 3.5.99.11
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