| Entry |
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| Name |
bis(5'-nucleosyl)-tetraphosphatase (asymmetrical);
bis(5'-guanosyl)-tetraphosphatase;
bis(5'-adenosyl)-tetraphosphatase;
diguanosinetetraphosphatase (asymmetrical);
dinucleosidetetraphosphatase (asymmetrical);
diadenosine P1,P4-tetraphosphatase;
dinucleoside tetraphosphatase;
1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase
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| Class |
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
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| Sysname |
P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase
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| Reaction(IUBMB) |
P1,P4-bis(5'-guanosyl) tetraphosphate + H2O = GTP + GMP [RN: R01232]
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| Reaction(KEGG) |
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| Substrate |
P1,P4-bis(5'-guanosyl) tetraphosphate [CPD: C01261];
H2O [CPD: C00001]
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| Product |
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| Comment |
Also acts on bis(5'-xanthosyl)-tetraphosphate and, more slowly, on bis(5'-adenosyl)-tetraphosphate and bis(5'-uridyl)-tetraphosphate [cf. EC 3.6.1.41 bis(5'-nucleosyl)-tetraphosphatase (symmetrical)]
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| History |
EC 3.6.1.17 created 1972, modified 1976, modified 1986
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| Pathway |
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| Orthology |
| K01518 | bis(5'-nucleosidyl)-tetraphosphatase |
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| Genes |
» show all
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| Reference |
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| Authors |
Jakubowski H, Guranowski A. |
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| Title |
Enzymes hydrolyzing ApppA and/or AppppA in higher plants. Purification and some properties of diadenosine triphosphatase, diadenosine tetraphosphatase, and phosphodiesterase from yellow lupin (Lupinus luteus) seeds. |
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| Journal |
J Biol Chem 258:9982-9 (1983) |
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| Reference |
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| Authors |
Vallejo CG, Lobaton CD, Quintanilla M, Sillero A, Sillero MA. |
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| Title |
Dinucleosidasetetraphosphatase in rat liver and Artemia salina. |
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| Journal |
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| Reference |
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| Authors |
Warner AH, Finamore FJ. |
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| Title |
Isolation, purification, and characterization of P1,P4-diguanosine 5'-tetraphosphate asymmetrical-pyrophosphohydrolase from brine shrimp eggs. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.6.1.17 |
| ExPASy - ENZYME nomenclature database: | 3.6.1.17 |
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| LinkDB |
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