KEGG   ENZYME: 3.6.1.69
Entry
EC 3.6.1.69                 Enzyme                                 

Name
8-oxo-(d)GTP phosphatase;
mutT1 (gene name)
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
Sysname
8-oxo-dGTP diphosphohydrolase
Reaction(IUBMB)
(1) 8-oxo-GTP + H2O = 8-oxo-GDP + phosphate [RN:R12532];
(2) 8-oxo-dGTP + H2O = 8-oxo-dGDP + phosphate [RN:R12533]
Reaction(KEGG)
R12532 R12533
Substrate
8-oxo-GTP [CPD:C22234];
H2O [CPD:C00001];
8-oxo-dGTP [CPD:C19967]
Product
8-oxo-GDP [CPD:C22235];
phosphate [CPD:C00009];
8-oxo-dGDP [CPD:C20176]
Comment
The enzyme, characterized from the bacterium Mycobacterium tuberculosis, catalyses the hydrolysis of both 8-oxo-GTP and 8-oxo-dGTP, thereby preventing transcriptional and translational errors caused by oxidative damage. The enzyme is highly specific. Unlike EC 3.6.1.55, 8-oxo-dGTP diphosphatase, it removes only a single phosphate group. The nucleoside diphosphate products are hydrolysed further by EC 3.6.1.58, 8-oxo-dGDP phosphatase.
History
EC 3.6.1.69 created 2019
Orthology
K23258  8-oxo-(d)GTP phosphatase
Genes
MSX: AU14_09890
MPQ: ABA45_04625
MSQ: BKP64_09945
HMI: soil367_13815
MICC: AUP74_00379
MASW: AM586_14985
MTIM: DIR46_02805
TBD: Tbd_2635
CFH: C1707_20065
BDQ: CIK05_11385
MTU: Rv2985(mutT1)
MTV: RVBD_2985
MTC: MT3063
MRA: MRA_3014(mutT1)
MTUR: CFBS_3148(mutT1)
MTO: MTCTRI2_3044(mutT1)
MTD: UDA_2985(mutT1)
MTN: ERDMAN_3271(mutT1)
MTUB: MT7199_3021(mutT1)
MTUC: J113_20805
MTUE: J114_15945
MTUH: I917_20960
MTUL: TBHG_02915
MTUT: HKBT1_3135(mutT1)
MTUU: HKBT2_3140(mutT1)
MTQ: HKBS1_3142(mutT1)
MBO: BQ2027_MB3009(mutT1)
MBB: BCG_3006(mutT1)
MBT: JTY_3001(mutT1)
MBM: BCGMEX_3002(mutT1)
MBX: BCGT_2825
MAF: MAF_29900(mutT1)
MMIC: RN08_3294
MCE: MCAN_30071(mutT1)
MCQ: BN44_60468(mutT)
MCV: BN43_40693(mutT)
MCX: BN42_40989(mutT)
MCZ: BN45_51399(mutT)
MLE: ML1682
MLB: MLBr01682
MPA: MAP_3023(mutT1)
MAO: MAP4_0777
MAVI: RC58_03810
MAVU: RE97_03815
MAV: MAV_3835
MIT: OCO_36550
MIA: OCU_36590
MID: MIP_05529
MYO: OEM_37190
MIR: OCQ_37750
MLP: MLM_3045
MUL: MUL_1971(mutT1)
MMC: Mmcs_1924
MKM: Mkms_1970
MJL: Mjls_1904
MMI: MMAR_1729(mutT1)
MMAE: MMARE11_16480(mutT1)
MMM: W7S_18285
MLI: MULP_01885(mutT1)
MHAD: B586_15615
MSHG: MSG_01588(mutT1)
MFJ: MFLOJ_17170(mutT1)
MXE: MYXE_33810(mutT1)
MNV: MNVI_31470(mutT1)
MSG: MSMEI_2330(mutT1)
MVA: Mvan_2138
MGI: Mflv_4224
MPHL: MPHLCCUG_02062(mutT4_1)
MVQ: MYVA_2027
MHAS: MHAS_00953(mutT1)
MDU: MDUV_23880(mutT1)
MDR: MDOR_13110(mutT1)
MAB: MAB_3291
MABB: MASS_3236
MCHE: BB28_16605
MSTE: MSTE_03268
MSAL: DSM43276_03086(mutT4_1)
MJD: JDM601_2688(mutT1)
MTER: 4434518_02634(mutT1)
MMIN: MMIN_03880(mutT1)
MHIB: MHIB_21200(mutT1)
ASD: AS9A_3182
MKR: MKOR_17470(mutT1)
CGL: NCgl1264(Cgl1318)
CGB: cg1490
CGU: WA5_1264
CGT: cgR_1392
CGM: cgp_1490
CGJ: AR0_07100
CEF: CE1429
CDI: DIP1129
CDIP: ERS451417_01044(mutT2)
CJK: jk1219
CUR: cu0776
CPL: Cp3995_0927(mutT2)
CPP: CpP54B96_0923(mutT2)
CPZ: CpPAT10_0909(mutT2)
COR: Cp267_0950(mutT2)
COD: Cp106_0896(mutT2)
COS: Cp4202_0901(mutT2)
CPSE: CPTA_01476
CPSU: CPTB_00056
CPSF: CPTC_01468
CRD: CRES_1313
CUN: Cul210932_1015(mutT2)
CUS: CulFRC11_0985(mutT2)
CUQ: Cul210931_0973(mutT2)
CUZ: Cul05146_1040(mutT2)
CUJ: CUL131002_0997c(mutT2)
CVA: CVAR_1748
CTER: A606_07055
COA: DR71_1960
CMQ: B840_05500(mutT1)
CSP: WM42_0197
CPHO: CPHO_06650
CGV: CGLAU_05800(mutT1)
CAQU: CAQU_05665
CAMG: CAMM_07590
CPEG: CPELA_06240(mutT1)
CEE: CENDO_05195(mutT1)
CGK: CGERO_04960(mutT1)
NFA: NFA_42090
RER: RER_24110(mutT)
REY: O5Y_11320
ROP: ROP_02400 ROP_65530(mutT)
REQ: REQ_31330
RHB: NY08_1488
RFA: A3L23_04718(mutT1)
RHS: A3Q41_03552(mutT1)
RHU: A3Q40_01317(mutT1)
RRT: 4535765_03148(nudG_2)
RCR: NCTC10994_04098(nudG_2)
GBR: Gbro_3212
GOR: KTR9_3251
GOM: D7316_00060(mutT1)
TPR: Tpau_2845
SRT: Srot_0986
CMI: CMM_2504
CMS: CMS2728
CMC: CMN_02457
MTS: MTES_2719
MOO: BWL13_00859(mutT1)
MLV: CVS47_02255(mutT1)
MOY: CVS54_02820(mutT1)
AUW: AURUGA1_00278(mutT4)
ART: Arth_3015
ARR: ARUE_c31360(mutT)
ARM: ART_2165
AAU: AAur_2989
ACH: Achl_2727
KRH: KRH_05700(mutT)
BCV: Bcav_3427
JDE: Jden_2236
LMOI: VV02_07145
IDO: I598_1984(ndx1)
CFL: Cfla_2816
SERJ: SGUI_2592
BLIN: BLSMQ_3337
PAC: PPA0342
PAW: PAZ_c03600(mutT)
PACC: PAC1_01760
PACH: PAGK_0363
CACN: RN83_02185
PFRE: RM25_1902
ACIJ: JS278_00737(mutT1)
MPH: MLP_47710(mutT)
NCA: Noca_4264
NDK: I601_1704(ndx1)
KFL: Kfla_0965
PSIM: KR76_22975
TFU: Tfu_0324
NDA: Ndas_5221
NAL: B005_2821
TCU: Tcur_0260
SRO: Sros_8612
NML: Namu_1481
GOB: Gobs_4051
MMAR: MODMU_4460
KRA: Krad_0876
SEN: SACE_6141
SACC: EYD13_04950(mutT1)
AMD: AMED_1727
AMN: RAM_08770
AMM: AMES_1714
AMZ: B737_1715
AOI: AORI_6143
AJA: AJAP_08695(mutT1)
AMYY: YIM_10170
AORI: SD37_30115
PDX: Psed_1835
PSEA: WY02_10140
PSEE: FRP1_04105
PSEH: XF36_18730
PAUT: Pdca_53320
AMI: Amir_6003
SESP: BN6_71860(mutT1)
KAL: KALB_7398
ACTI: UA75_26415
ACAD: UA74_25830
AHG: AHOG_23730(mutT1)
ALO: CRK58731
SAQ: Sare_1152
MIL: ML5_1579
ASE: ACPL_7343
ACTN: L083_6934
AFS: AFR_36675
ACTS: ACWT_7213
CAI: Caci_8260
SNA: Snas_4995
TPYO: X956_09250
BLO: BL1258(mutT1)
BLJ: BLD_1592(mutT3)
BLN: Blon_2329
BLON: BLIJ_2405
BLF: BLIF_1852
BLL: BLJ_1856
BLB: BBMN68_1517(mutT3)
BLM: BLLJ_1771
BLG: BIL_05520
BAD: BAD_0126(mutT1)
BADL: BADO_0136
BLA: BLA_0191(mutT)
BBB: BIF_01427
BBC: BLC1_0193
BLV: BalV_0197
BLW: W7Y_0198
BLS: W91_0202
BANI: Bl12_0187
BANL: BLAC_01050
BANM: EN10_01035
BDE: BDP_0204
BDN: BBDE_0192
BBP: BBPR_1764
BBI: BBIF_1706
BBF: BBB_1762(mutT)
BBRU: Bbr_1771
BBRE: B12L_1704
BBRV: B689b_1802
BBRJ: B7017_1968
BBRC: B7019_1941
BBRN: B2258_1794
BBRS: BS27_1767
BBRD: BBBR_1776
BAST: BAST_1554
BTP: D805_0215
BCOR: BCOR_1341
BKS: BBKW_0139
BCAT: BBCT_0120
BPSP: AH67_01000
BANG: BBAG_1380
BPSC: BBPC_0135
BSCA: BBSC_2348
GVG: HMPREF0421_20086(mutT)
SIJ: SCIP_1325
PDO: PSDT_0098
AFO: Afer_1187
SRU: SRU_2238
SRM: SRM_02466
RMR: Rmar_0037
LBY: Lbys_0044
HSW: Hsw_2908
 » show all
Reference
1  [PMID:23463507]
  Authors
Patil AG, Sang PB, Govindan A, Varshney U
  Title
Mycobacterium tuberculosis MutT1 (Rv2985) and ADPRase (Rv1700) proteins constitute a two-stage mechanism of 8-oxo-dGTP and 8-oxo-GTP detoxification and adenosine to cytidine mutation avoidance.
  Journal
J Biol Chem 288:11252-62 (2013)
DOI:10.1074/jbc.M112.442566
  Sequence
[mtu:Rv2985]
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.69
IUBMB Enzyme Nomenclature: 3.6.1.69
ExPASy - ENZYME nomenclature database: 3.6.1.69
BRENDA, the Enzyme Database: 3.6.1.69
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