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Entry
EC 3.6.3.33                 Enzyme                                 

Name
vitamin B12-transporting ATPase
Class
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to catalyse transmembrane movement of substances
BRITE hierarchy
Sysname
ATP phosphohydrolase (vitamin B12-importing)
Reaction(IUBMB)
ATP + H2O + vitamin B12out = ADP + phosphate + vitamin B12in [RN:R00086]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001];
vitamin B12 [CPD:C05776]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
vitamin B12 [CPD:C05776]
Comment
ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. A bacterial enzyme that imports cobalamin derivatives.
History
EC 3.6.3.33 created 2000
Orthology
K06074  vitamin B12 transport system ATP-binding protein
Genes
ECO: b1709(btuD)
ECJ: JW1699(btuD)
ECD: ECDH10B_1845(btuD)
EBW: BWG_1523(btuD)
ECOK: ECMDS42_1382(btuD)
ECE: Z2738(btuD)
ECS: ECs2416
ECF: ECH74115_2427(btuD)
ETW: ECSP_2276(btuD)
ELX: CDCO157_2250
EOJ: ECO26_2438(btuD)
EOI: ECO111_2179(btuD)
EOH: ECO103_1853(btuD)
ECG: E2348C_1794(btuD)
EOK: G2583_2106(btuD)
ECC: c2105(btuD)
ECP: ECP_1657
ECI: UTI89_C1902(btuD)
ECV: APECO1_784(btuC)
ECX: EcHS_A1789(btuD)
ECW: EcE24377A_1928(btuD)
ECM: EcSMS35_1481(btuD)
ECY: ECSE_1834
ECR: ECIAI1_1765(btuD)
ECQ: ECED1_1911(btuD)
ECK: EC55989_1877(btuD)
ECT: ECIAI39_1344(btuD)
EOC: CE10_1989(btuD)
EUM: ECUMN_2000(btuD)
ECZ: ECS88_1760(btuD)
ELO: EC042_1876(btuD)
ELH: ETEC_1742
ESE: ECSF_1570
ESO: O3O_13950
ESM: O3M_11650
ESL: O3K_11685
EBR: ECB_01678(btuD)
EBD: ECBD_1936
EKF: KO11_14200(btuD)
EAB: ECABU_c19640(btuD)
EDJ: ECDH1ME8569_1653(btuD)
EIH: ECOK1_1829(btuD)
ENA: ECNA114_1757(btuD)
ELW: ECW_m1878(btuD)
ELL: WFL_09200(btuD)
ELC: i14_1927(btuD)
ELD: i02_1927(btuD)
ELP: P12B_c1374(btuD)
EBL: ECD_01678(btuD)
EBE: B21_01667(btuD)
ELF: LF82_0250(btuD)
ECOI: ECOPMV1_01808(btuD)
ECOJ: P423_09115
ECOO: ECRM13514_2206(btuD)
ECOH: ECRM13516_2111(btuD)
ECOS: EC958_1931(btuD)
EFE: EFER_1355(btuD)
EAL: EAKF1_ch4343(btuD)
STY: STY1768(btuD)
STT: t1223(btuD)
STM: STM1342(btuD)
SEO: STM14_1629(btuD)
SEY: SL1344_1276(btuD)
SEJ: STMUK_1309(btuD)
SEB: STM474_1346(btuD)
SEF: UMN798_1398(btuD)
SENR: STMDT2_12751(btuD)
SEND: DT104_13191(btuD)
SENI: CY43_06830
SPT: SPA1501(btuD)
SEK: SSPA1393
SEI: SPC_2389(btuD)
SEC: SCH_1361(btuD)
SHB: SU5_01960
SENS: Q786_08545
SED: SeD_A2003
SEG: SG1775(btuD)
SEL: SPUL_1158(btuD)
SEGA: SPUCDC_1158(btuD)
SET: SEN1702(btuD)
SENA: AU38_08815
SENO: AU37_08820
SENV: AU39_08825
SENQ: AU40_09840
SENL: IY59_09010
SEEP: I137_05330
SENB: BN855_13770(btuD)
SENE: IA1_06615
SBG: SBG_1194(btuD)
SBZ: A464_1387
SFL: SF1522(btuD)
SFX: S1639(btuD)
SFV: SFV_1514(btuD)
SFE: SFxv_1705(btuD)
SFN: SFy_2178
SFS: SFyv_2231
SFT: NCTC1_01641(btuD)
SSN: SSON_1449(btuD)
SBO: SBO_1419(btuD)
SBC: SbBS512_E1913(btuD)
SDY: SDY_1804(btuD)
ENC: ECL_02410
ECLO: ENC_14080
EEC: EcWSU1_01819(btuD)
ECLX: LI66_09185
ECLY: LI62_09960
ECLZ: LI64_09250
ESA: ESA_02111
CSK: ES15_2266(btuD)
CTU: CTU_18540(btuD)
KPN: KPN_02166(btuD)
KPU: KP1_3269(btuD)
KPP: A79E_2073
KPT: VK055_0290(btuD)
KPE: KPK_2152(btuD)
KPR: KPR_2714(btuD)
KPJ: N559_2116
KPX: PMK1_04533(btuD)
KPNU: LI86_10515
KPNK: BN49_3274(btuD)
KVA: Kvar_2025
KOX: KOX_22880
KOE: A225_3456
EAE: EAE_17045
EAR: CCG30484
CKO: CKO_01735
CRO: ROD_13461(btuD)
CAMA: F384_06095
EBT: EBL_c15980(btuD)
EBF: D782_1948
PSTS: E05_12420
YPE: YPO2423(btuD)
YPK: y1916(btuD)
YPA: YPA_1767
YPN: YPN_1877
YPM: YP_2210(btuD)
YPZ: YPZ3_1464
YPD: YPD4_1429
YPX: YPD8_1516
YPH: YPC_2058(btuD)
YPW: CH59_4257
YPJ: CH55_499
YPV: BZ15_1102
YPL: CH46_2682
YPS: YPTB2331(btuD)
YPO: BZ17_123
YPI: YpsIP31758_1722(btuD)
YPY: YPK_1830
YPB: YPTS_2406
YPQ: DJ40_4254
YPU: BZ21_1619
YPR: BZ20_3912
YPC: BZ23_1905
YPF: BZ19_1696
YEN: YE2193(btuD)
YEY: Y11_07971
YEW: CH47_1628(btuD)
YET: CH48_3628
YEE: YE5303_20351(btuD)
YAL: AT01_259
YFR: AW19_1399
YIN: CH53_4136
YKR: CH54_263
YRO: CH64_738
YRU: BD65_482
SPE: Spro_2153
SRL: SOD_c19670(btuD)
SPLY: Q5A_010885(btuD)
SMAF: D781_1984
SMW: SMWW4_v1c21820(btuD)
SMAR: SM39_1614(btuD)
SMAC: SMDB11_1427(btuD)
SERF: L085_17855
RAA: Q7S_14245
ECA: ECA1834(btuD)
PATR: EV46_08780
PATO: GZ59_27690
PCT: PC1_2467
PEC: W5S_2754
SOD: Sant_2070(btuD)
DDD: Dda3937_03648(btuD)
DDQ: DDI_2468
EBI: EbC_18900(btuD)
EGE: EM595_1671(btuD)
PAM: PANA_1704(btuD)
PLF: PANA5342_2511(btuD)
PAJ: PAJ_1052(btuD)
PVA: Pvag_1144(btuD)
PSTW: DSJ_12905
PLU: plu2661(btuD)
PAY: PAU_01874(btuD)
PMR: PMI1042(btuD)
PMIB: BB2000_1079(btuD)
XBO: XBJ1_2537(btuD)
XBV: XBW1_3013(btuD)
XNE: XNC1_1834(btuD)
XNM: XNC2_1779(btuD)
XPO: XPG1_1545(btuD)
PSI: S70_19350
PSX: DR96_2782
PRG: RB151_019220(btuD)
MMK: MU9_2439
ETR: ETAE_1806(btuD)
ETD: ETAF_1633(btuD)
ETE: ETEE_3850(btuD)
PSHI: SAMEA2665130_1515(btuD)
VCH: VC1245
VCI: O3Y_05790
VCS: MS6_1027
VVU: VV1_2781
VVY: VV1481
VPA: VP1312
VPB: VPBB_1236
VAG: N646_0350
VSP: VS_1695
VAN: VAA_03078
VAU: VANGNB10_cI1522c(btuD)
VSC: VSVS12_01612(btuD)
VTA: A0506(btuD)
PPR: PBPRA2151(SF1522)
PSEO: OM33_15130
PSPO: PSPO_b1823(btuD)
PTU: PTUN_b0956(btuD)
AMAL: I607_06450
AMAE: I876_06740
AMAO: I634_06860
AMAD: I636_07280
AMAI: I635_07190
AMAG: I533_06795
AMAC: MASE_06310
MVS: MVIS_3061(btuD)
AHA: AHA_2735
ASA: ASA_1638(btuD)
AVR: B565_1402
AMED: B224_3022
ASR: WL1483_12(btuD)
TAU: Tola_1733
OCE: GU3_08245
 » show all
Taxonomy
Reference
1  [PMID:7569321]
  Authors
Kuan G, Dassa E, Saurin W, Hofnung M, Saier MH Jr.
  Title
Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases.
  Journal
Res Microbiol 146:271-8 (1995)
DOI:10.1016/0923-2508(96)81050-3
Reference
2  [PMID:9889977]
  Authors
Saier MH Jr.
  Title
Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya.
  Journal
Adv Microb Physiol 40:81-136 (1998)
Reference
3  [PMID:3528129]
  Authors
Friedrich MJ, de Veaux LC, Kadner RJ.
  Title
Nucleotide sequence of the btuCED genes involved in vitamin B12 transport in Escherichia coli and homology with components of periplasmic-binding-protein-dependent transport systems.
  Journal
J Bacteriol 167:928-34 (1986)
DOI:10.1128/JB.167.3.928-934.1986
  Sequence
[eco:b1709]
Other DBs
ExplorEnz - The Enzyme Database: 3.6.3.33
IUBMB Enzyme Nomenclature: 3.6.3.33
ExPASy - ENZYME nomenclature database: 3.6.3.33
BRENDA, the Enzyme Database: 3.6.3.33
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