KEGG   ENZYME: 3.6.3.49Help
Entry
EC 3.6.3.49                 Enzyme                                 

Name
channel-conductance-controlling ATPase
Class
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to catalyse transmembrane movement of substances
BRITE hierarchy
Sysname
ATP phosphohydrolase (channel-conductance-controlling)
Reaction(IUBMB)
ATP + H2O = ADP + phosphate [RN:R00086]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009]
Comment
ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains. Does not undergo phosphorylation during the transport process. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels.
History
EC 3.6.3.49 created 2000
Orthology
K05031  cystic fibrosis transmembrane conductance regulator
Genes
HSA: 1080(CFTR)
PTR: 463674(CFTR)
PPS: 100989405(CFTR)
GGO: 101132066(CFTR)
PON: 100137035(CFTR)
NLE: 100601480(CFTR)
MCC: 574346(CFTR)
MCF: 102130331(CFTR)
CSAB: 103226777(CFTR)
RRO: 104682625(CFTR)
RBB: 108526537(CFTR)
CJC: 100415251(CFTR)
SBQ: 101036459(CFTR)
MMU: 12638(Cftr)
RNO: 24255(Cftr)
CGE: 100754506(Cftr)
NGI: 103737361(Cftr)
HGL: 101709472(Cftr)
CCAN: 109679300(Cftr) 109680514
OCU: 100009471(CFTR)
TUP: 102490714(CFTR)
CFA: 492302(CFTR)
AML: 100478723(CFTR)
UMR: 103676590(CFTR)
ORO: 101363648(CFTR)
FCA: 492308(CFTR)
PTG: 102956215(CFTR)
AJU: 106970664(CFTR)
BTA: 281067(CFTR)
BOM: 102264773(CFTR) 102266351
BIU: 109557891(CFTR)
PHD: 102332344(CFTR)
CHX: 102179446(CFTR)
OAS: 443347(CFTR)
SSC: 403154(CFTR)
CFR: 102505598(CFTR)
CDK: 105085325(CFTR)
BACU: 103004581(CFTR)
LVE: 103088529(CFTR)
OOR: 101278319(CFTR)
ECB: 100071259(CFTR)
EPZ: 103550601(CFTR)
EAI: 106829379(CFTR)
MYB: 102257625(CFTR)
MYD: 102773631(CFTR)
HAI: 109376431
RSS: 109453461(CFTR)
PALE: 102884577(CFTR)
LAV: 100662653(CFTR)
TMU: 101346801
MDO: 100014119(CFTR)
SHR: 100919086(CFTR)
OAA: 100078764(CFTR)
GGA: 100049619(CFTR)
MGP: 100545354(CFTR)
CJO: 107309076(CFTR)
APLA: 101803386(CFTR)
ACYG: 106042053(CFTR)
TGU: 100222243(CFTR)
GFR: 102041165(CFTR)
FAB: 101809710(CFTR)
PHI: 102114534(CFTR)
PMAJ: 107205064(CFTR)
CCW: 104698445(CFTR)
FPG: 101921929(CFTR)
FCH: 102050923(CFTR)
CLV: 102089481(CFTR)
EGZ: 104133415(CFTR)
AAM: 106488125(CFTR)
ASN: 102369471(CFTR)
AMJ: 102563163(CFTR)
PSS: 102447829(CFTR)
CMY: 102936252(CFTR)
CPIC: 101933840(CFTR)
ACS: 100559531(cftr)
PVT: 110077041(CFTR)
PBI: 103057487(CFTR)
GJA: 107114507(CFTR)
XLA: 108712361 373725(cftr-A)
XTR: 100486085(cftr)
NPR: 108802076(CFTR)
DRE: 559080(cftr)
SANH: 107660943(cftr) 107672176
CCAR: 109110485(cftr) 109110487
IPU: 108264684(cftr)
AMEX: 103032690(cftr)
TRU: 492310(cftr)
LCO: 104925520(cftr)
MZE: 101473042(cftr)
OLA: 101161380(cftr)
XMA: 102231389(cftr)
PRET: 103465638(cftr)
NFU: 107388351(cftr)
CSEM: 103379580(cftr)
LCF: 108893910(cftr)
HCQ: 109530830(cftr) 109530831
BPEC: 110155111(cftr)
ELS: 105029518(cftr)
SFM: 108931616(cftr)
LCM: 102346483(CFTR)
CMK: 103179362(cftr)
 » show all
Taxonomy
Reference
1  [PMID:9147660]
  Authors
Chen M, Zhang JT.
  Title
Membrane insertion, processing, and topology of cystic fibrosis transmembrane conductance regulator (CFTR) in microsomal membranes.
  Journal
Mol Membr Biol 13:33-40 (1996)
Reference
2  [PMID:9013845]
  Authors
Tusnady GE, Bakos E, Varadi A, Sarkadi B.
  Title
Membrane topology distinguishes a subfamily of the ATP-binding cassette (ABC) transporters.
  Journal
FEBS Lett 402:1-3 (1997)
DOI:10.1016/S0014-5793(96)01478-0
Reference
3  [PMID:9922375]
  Authors
Sheppard DN, Welsh MJ.
  Title
Structure and function of the CFTR chloride channel.
  Journal
Physiol Rev 79:S23-45 (1999)
DOI:10.1152/physrev.1999.79.1.S23
Other DBs
ExplorEnz - The Enzyme Database: 3.6.3.49
IUBMB Enzyme Nomenclature: 3.6.3.49
ExPASy - ENZYME nomenclature database: 3.6.3.49
BRENDA, the Enzyme Database: 3.6.3.49
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