ENZYME: 3.6.4.6
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Entry
EC 3.6.4.6 Enzyme
Name
vesicle-fusing ATPase
Class
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to facilitate cellular and subcellular movement
BRITE hierarchy
Sysname
ATP phosphohydrolase (vesicle-fusing)
Reaction(IUBMB)
ATP + H2O = ADP + phosphate
Substrate
ATP [CPD:
C00002
];
H2O [CPD:
C00001
]
Product
ADP [CPD:
C00008
];
phosphate [CPD:
C00009
]
Comment
A large family of ATP-hydrolysing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. They belong to the AAA-type (_A_TPase _a_ssociated with a variety of cell _a_ctivities) ATPase superfamily. They include peroxin, which apparently is involved in Zellweger's syndrome.
History
EC 3.6.4.6 created 2000
Orthology
K06027
vesicle-fusing ATPase
Genes
HSA:
4905
(NSF)
PTR:
107968982
(NSF)
PPS:
100991652
(NSF)
GGO:
101135519
(NSF)
PON:
100174078
(NSF)
NLE:
100597907
(NSF)
MCC:
715297
(NSF)
MCF:
101866905
(NSF)
CSAB:
103243257
(NSF)
RRO:
104682398
(NSF)
RBB:
108529363
(NSF)
CJC:
100399301
(NSF)
SBQ:
101047038
(NSF)
MMU:
18195
(Nsf)
MCAL:
110304882
(Nsf)
MPAH:
110331334
(Nsf)
RNO:
60355
(Nsf)
MUN:
110545640
(Nsf)
CGE:
100770898
(Nsf)
NGI:
103724771
(Nsf)
HGL:
101723819
(Nsf)
CCAN:
109684808
(Nsf)
OCU:
100353806
(NSF)
TUP:
102488598
(NSF)
CFA:
490921
(NSF)
VVP:
112920684
(NSF)
AML:
100472215
(NSF)
UMR:
103665609
(NSF)
UAH:
113265315
(NSF)
ORO:
101374156
(NSF)
ELK:
111158089
FCA:
101088797
(NSF)
PTG:
102966575
(NSF)
PPAD:
109259744
(NSF)
AJU:
106988844
(NSF)
BTA:
504457
(NSF)
BOM:
102280725
(NSF)
BIU:
109574088
(NSF)
BBUB:
102416575
(NSF)
CHX:
102190729
(NSF)
OAS:
101120344
(NSF)
SSC:
100624659
(NSF)
CFR:
102514292
(NSF)
CDK:
105090436
(NSF)
BACU:
103014548
(NSF)
LVE:
103082075
(NSF)
OOR:
101279405
(NSF)
DLE:
111182577
(NSF)
PCAD:
102993946
(NSF)
ECB:
100063690
(NSF)
EPZ:
103552910
(NSF)
EAI:
106836491
(NSF)
MYB:
102241084
(NSF)
102249817
MYD:
102755866
(NSF)
MNA:
107530228
(NSF)
HAI:
109380316
(NSF)
DRO:
112316511
(NSF)
PALE:
102887160
(NSF)
RAY:
107508174
(NSF)
MJV:
108388960
(NSF)
LAV:
100659266
(NSF)
TMU:
101341642
MDO:
100024726
(NSF)
SHR:
100919423
(NSF)
PCW:
110215749
(NSF)
OAA:
100082648
(NSF)
GGA:
419972
(NSF)
MGP:
100550059
(NSF)
CJO:
107325012
(NSF)
NMEL:
110388428
(NSF)
APLA:
101802966
(NSF)
ACYG:
106049233
(NSF)
TGU:
100228489
(NSF)
LSR:
110475619
(NSF)
SCAN:
103821644
(NSF)
GFR:
102038083
(NSF)
FAB:
101816144
(NSF)
PHI:
102111556
(NSF)
PMAJ:
107215181
(NSF)
CCAE:
111940042
(NSF)
CCW:
104698517
(NSF)
ETL:
114067379
(NSF)
FPG:
101921214
(NSF)
FCH:
102049327
(NSF)
CLV:
102086980
(NSF)
EGZ:
104126010
(NSF)
NNI:
104017397
(NSF)
ACUN:
113489208
(NSF)
PADL:
103920627
(NSF)
AAM:
106496693
(NSF)
ASN:
102372124
(NSF)
AMJ:
102567906
(NSF)
PSS:
102444813
(NSF)
CMY:
102941212
(NSF)
CPIC:
101952206
(NSF)
ACS:
100555215
(nsf)
PVT:
110081373
(NSF)
PBI:
103061169
(NSF)
PMUR:
107303033
(NSF)
TSR:
106552227
(NSF)
PMUA:
114581549
(NSF)
GJA:
107125526
(NSF)
XLA:
100049722
(nsf.L)
779070
(nsf)
XTR:
780249
(nsf)
NPR:
108797417
(NSF)
DRE:
368483
(nsfa)
554200
(nsfb)
SRX:
107709994
107723637
107733448
107753041
SANH:
107657277
107665886
107688085
107689618
SGH:
107584403
107590408
107601245
CCAR:
109059813
109099175
IPU:
108260232
(NSF)
108273757
PHYP:
113527349
113528553
(nsf)
AMEX:
103030471
103037152
EEE:
113584168
113588777
TRU:
101068366
101069418
TNG:
GSTEN00011477G001
GSTEN00021065G001
LCO:
104925164
104926831
NCC:
104961605
(nsf)
MZE:
101470525
101477540
ONL:
100697603
100706831
OLA:
101155094
101174468
XMA:
102217733
102222911
(nsf)
XCO:
114148296
(nsf)
114152039
PRET:
103468292
(nsf)
103481708
CVG:
107093238
107101841
(nsf)
NFU:
107376205
(nsf)
107387615
KMR:
108245926
108247085
ALIM:
106521948
106525242
(nsf)
AOCE:
111566414
(nsf)
111567365
CSEM:
103381862
103393665
POV:
109641366
LCF:
108892046
108898576
SDU:
111220290
111223780
SLAL:
111655429
111662501
HCQ:
109524779
109530164
BPEC:
110154189
110171223
(nsf)
MALB:
109962797
(nsf)
109972314
SASA:
100194814
(nsf)
106579324
106583880
106589298
OTW:
112223562
112224157
112258431
SALP:
111967675
111981726
ELS:
105007401
105028430
SFM:
108918791
108937311
PKI:
111845149
111859762
LCM:
102355580
(NSF)
CMK:
103187748
(nsf)
RTP:
109934347
(nsf)
BFO:
118405552
CIN:
100180685
SPU:
373397
(NSF)
APLC:
110983764
SKO:
100378822
DME:
Dmel_CG1618
(comt)
Dmel_CG31495
(CG31495)
Dmel_CG33101
(Nsf2)
DER:
6551073
6553372
DSE:
6606472
6618650
DSI:
Dsimw501_GD17110
(Dsim_GD17110)
Dsimw501_GD20472
(Dsim_GD20472)
Dsimw501_GD20473
(Dsim_GD20473)
DYA:
Dyak_GE17054
Dyak_GE24412
Dyak_GE24413
DAN:
6499194
6504094
DSR:
110176629
110176631
110180379
DPO:
Dpse_GA17281
Dpse_GA22832
DPE:
6587883
6600127
DMN:
108154583
108156738
DWI:
6650284
6652921
DGR:
Dgri_GH14042
Dgri_GH24638
DMO:
Dmoj_GI21685
Dmoj_GI24416
DAZ:
108609012
108619439
DNV:
108657392
108658923
DHE:
111594580
111598183
DVI:
6634750
6634946
MDE:
101899739
LCQ:
111681484
AGA:
AgaP_AGAP012684
AAG:
5571511
AALB:
109431384
CQU:
CpipJ_CPIJ003150
AME:
725680
BIM:
100743418
100744922
BTER:
100647002
100648372
CCAL:
108629006
OBB:
114874782
SOC:
105204561
MPHA:
105836005
AEC:
105154464
ACEP:
105621067
PBAR:
105430758
VEM:
105557591
HST:
105188960
DQU:
106741850
CFO:
105257970
LHU:
105674580
PGC:
109853969
OBO:
105275382
PCF:
106791958
NVI:
100119103
(Nsf)
CSOL:
105365005
MDL:
103577888
TCA:
660439
DPA:
109535171
ATD:
109607524
NVL:
108559154
BMOR:
692733
BMAN:
114250128
DPL:
KGM_203261
PMAC:
106716533
PRAP:
110998211
HAW:
110374809
TNL:
113502528
113502529
PXY:
105391201
105396848
API:
100169274
DNX:
107168753
AGS:
114123284
RMD:
113560288
BTAB:
109035021
CLEC:
106667423
PHU:
Phum_PHUM047300
Phum_PHUM047310
ZNE:
110832521
110838887
FCD:
110860717
DPX:
DAPPUDRAFT_118650
DAPPUDRAFT_240520
DAPPUDRAFT_240595
DAPPUDRAFT_240599
DAPPUDRAFT_48480
DAPPUDRAFT_60285
PVM:
113821213
ISC:
IscW_ISCW007723
TUT:
107371705
DPTE:
113791499
113796740
CSCU:
111634503
PTEP:
107438353
CEL:
CELE_H15N14.2
(nsf-1)
CBR:
CBG19441
(Cbr-nsf-1)
BMY:
Bm1_27155
Bm1_27160
LOA:
LOAG_18613
NAI:
NECAME_12151
TSP:
Tsp_11763
HRO:
HELRODRAFT_189514
LGI:
LOTGIDRAFT_207527
PCAN:
112567771
CRG:
105347797
MYI:
110442889
OBI:
106877959
LAK:
106179612
SMM:
Smp_057320
SHX:
MS3_01139
OVI:
T265_02769
NVE:
5507652
EPA:
110239477
ADF:
107343147
AMIL:
114957026
PDAM:
113682967
SPIS:
111324881
DGT:
114521797
HMG:
100203653
(nsf)
TAD:
TRIADDRAFT_22168
AQU:
100638291
109580865
109585831
ATH:
AT4G04910
(NSF)
ALY:
9304755
9305915
9310886
CRB:
17883649
CSAT:
104707647
104716346
104722879
104733422
104737346
EUS:
EUTSA_v10028462mg
BRP:
103839802
103858677
103870057
BNA:
106362943
106366874
106376224
106376378
106404873
106407019
106415894
106415910
106438745
BOE:
106319486
106328335
106330061
106344373
RSZ:
108828444
108841767
THJ:
104806293
104812936
CPAP:
110817824
110818850
CIT:
102616948
CIC:
CICLE_v10011146mg
TCC:
18596846
GRA:
105773260
105773414
GHI:
107895350
107901816
107960208
GAB:
108483534
108486490
DZI:
111278180
111280830
EGR:
104445168
104445275
104445277
GMX:
100779259
100791847
GSJ:
114376713
114419537
PVU:
PHAVU_002G228500g
VRA:
106769219
VAR:
108323342
VUN:
114178901
CCAJ:
109807601
MTR:
MTR_4g088885
CAM:
101504834
LJA:
Lj4g3v0451140.2
(Lj4g3v0451140.2)
ADU:
107480806
107489897
AIP:
107631234
LANG:
109331690
109349358
FVE:
101293960
101294098
101301725
101302830
101303994
RCN:
112166237
PPER:
18779341
PMUM:
103324770
PAVI:
110766784
MDM:
103408928
103446406
114825187
PXB:
103931891
103944206
ZJU:
107424747
CSV:
101217734
CMO:
103501723
MCHA:
111012583
CMAX:
111466302
111495493
CMOS:
111432603
111434206
CPEP:
111782851
111801908
RCU:
8279510
JCU:
105628980
105628982
105628984
105628986
105649544
HBR:
110635135
110635136
110636373
110648003
MESC:
110603743
110604472
POP:
18103026
7456793
PEU:
105128031
105138869
JRE:
109021786
QSU:
111987692
112014644
112035641
112037672
112039166
VVI:
100243494
SLY:
101264864
SPEN:
107008021
SOT:
102590007
CANN:
107872783
NTA:
107774494
107794928
107795805
107795806
107797742
107817451
NSY:
104212421
NTO:
104093939
104097183
104097184
104117416
NAU:
109230737
INI:
109151383
109181744
SIND:
105177003
OEU:
111375918
HAN:
110889642
110912858
LSV:
111907117
CCAV:
112506937
112513741
DCR:
108216429
108223278
BVG:
104907721
SOE:
110805496
CQI:
110693277
110714213
110720169
110725182
NNU:
104599597
104608226
PSOM:
113318184
113348821
OSA:
4339340
DOSA:
Os05t0519400-01
(Os05g0519400)
OBR:
102703038
BDI:
100826539
ATS:
109741064
(LOC109741064)
SBI:
8062246
ZMA:
100382060
SITA:
101764358
101775636
PDA:
103695578
103708933
EGU:
105040856
105047427
MUS:
103996094
103997044
DCT:
110097816
PEQ:
110036769
110037813
AOF:
109834042
109840902
ATR:
18448924
SMO:
SELMODRAFT_137147
SELMODRAFT_236078
SELMODRAFT_407213
SELMODRAFT_91155
PPP:
112278922
112287771
CRE:
CHLREDRAFT_187761
VCN:
VOLCADRAFT_80882
CSL:
COCSUDRAFT_13602
CVR:
CHLNCDRAFT_29882
APRO:
F751_1293
OLU:
OSTLU_30476
OSTLU_41487
OTA:
OT_ostta03g01510
OT_ostta06g04170
BPG:
Bathy05g04610
Bathy12g02880
MIS:
MICPUN_106780
MICPUN_113384
(NSFA)
MPP:
MICPUCDRAFT_1003
MICPUCDRAFT_31131
CME:
CYME_CMQ243C
GSL:
Gasu_52270
CCP:
CHC_T00006591001
SCE:
YBR080C
(SEC18)
AGO:
AGOS_AER169C
ERC:
Ecym_7426
KLA:
KLLA0_C14520g
KMX:
KLMA_30551
(SEC18)
LTH:
KLTH0E14190g
VPO:
Kpol_1052p6
ZRO:
ZYRO0G12738g
CGR:
CAGL0E04642g
CAGL0M01782g
NCS:
NCAS_0I01400
(NCAS0I01400)
NDI:
NDAI_0A07600
(NDAI0A07600)
TPF:
TPHA_0A03890
(TPHA0A03890)
TBL:
TBLA_0G03290
(TBLA0G03290)
TBLA_0I02090
(TBLA0I02090)
TDL:
TDEL_0D03210
(TDEL0D03210)
KAF:
KAFR_0C00290
(KAFR0C00290)
PPA:
PAS_chr3_0342
DHA:
DEHA2G10252g
PIC:
PICST_86905
(SEC18)
PGU:
PGUG_02778
SPAA:
SPAPADRAFT_71938
LEL:
LELG_03407
CAL:
CAALFM_C113580WA
(SEC18)
CTP:
CTRG_03639
COT:
CORT_0D02860
CDU:
CD36_12570
CTEN:
CANTEDRAFT_97824
YLI:
YALI0E29249g
CLU:
CLUG_03594
CLUS:
A9F13_01g05676
CAUR:
CJI97_000645
SLB:
AWJ20_2686
(SEC18)
PKZ:
C5L36_0A09890
NCR:
NCU03387
NTE:
NEUTE1DRAFT123357
(NEUTE1DRAFT_123357)
SMP:
SMAC_08261
PAN:
PODANSg7055
TTT:
THITE_2123254
MTM:
MYCTH_2311587
CTHR:
CTHT_0006660
MGR:
MGG_02418
TMN:
UCRPA7_814
SSCK:
SPSK_10361
FGR:
FGSG_10903
FPU:
FPSE_09801
FVR:
FVEG_11582
FOX:
FOXG_12838
NHE:
NECHADRAFT_104315
TRE:
TRIREDRAFT_62040
(nsf1)
TRR:
M419DRAFT_80503
MAW:
MAC_03602
MAJ:
MAA_02584
CMT:
CCM_08519
PLJ:
VFPFJ_06792
VAL:
VDBG_05437
VDA:
VDAG_07086
CFJ:
CFIO01_08436
SAPO:
SAPIO_CDS0972
ELA:
UCREL1_10804
PFY:
PFICI_09233
SSL:
SS1G_12225
BFU:
BCIN_05g05700
MBE:
MBM_07741
PSCO:
LY89DRAFT_783470
GLZ:
GLAREA_00476
ANI:
AN3098.2
AFM:
AFUA_3G12510
ACT:
ACLA_040350
NFI:
NFIA_064790
AOR:
AO090005000718
ANG:
ANI_1_1212024
(An02g08450)
AFV:
AFLA_079680
PCS:
Pc13g09960
PDP:
PDIP_29380
TMF:
PMAA_080990
CIM:
CIMG_03419
CPW:
CPC735_008000
PBL:
PAAG_07133
PBN:
PADG_00898
URE:
UREG_07243
ABE:
ARB_07749
TVE:
TRV_02911
AJE:
HCAG_06678
BGH:
BDBG_02964
PNO:
SNOG_03196
(SNOG_03195)
PTE:
PTT_18726
BZE:
COCCADRAFT_110603
BSC:
COCSADRAFT_35103
BOR:
COCMIDRAFT_85
AALT:
CC77DRAFT_970863
ZTR:
MYCGRDRAFT_86671
PFJ:
MYCFIDRAFT_49254
BCOM:
BAUCODRAFT_34311
NPA:
UCRNP2_8828
TML:
GSTUM_00009174001
SPO:
SPAC1834.11c
(sec18)
CNE:
CNF04190
CNB:
CNBF0670
CGI:
CGB_F1040W
TMS:
TREMEDRAFT_42251
TASA:
A1Q1_00230
TVS:
TRAVEDRAFT_115541
DSQ:
DICSQDRAFT_104646
PCO:
PHACADRAFT_250496
SHS:
STEHIDRAFT_71855
HIR:
HETIRDRAFT_62292
PSQ:
PUNSTDRAFT_85483
ADL:
AURDEDRAFT_183434
FME:
FOMMEDRAFT_88907
GTR:
GLOTRDRAFT_113953
LBC:
LACBIDRAFT_399620
MPR:
MPER_07585
MRR:
Moror_13841
CCI:
CC1G_01432
SCM:
SCHCODRAFT_71994
ABP:
AGABI1DRAFT72628
(AGABI1DRAFT_72628)
ABV:
AGABI2DRAFT188589
(AGABI2DRAFT_188589)
CPUT:
CONPUDRAFT_130827
SLA:
SERLADRAFT_461671
WSE:
WALSEDRAFT_51351
WIC:
J056_003102
UMA:
UMAG_01284
PFP:
PFL1_04054
MGL:
MGL_2556
MRT:
MRET_0534
MSYM:
MSY001_0267
PGR:
PGTG_00084
MLR:
MELLADRAFT_47546
ECU:
ECU03_1410
EIN:
Eint_031320
EHE:
EHEL_031340
ERO:
EROM_031290
NCE:
NCER_100455
MBR:
MONBRDRAFT_21577
MONBRDRAFT_22669
SRE:
PTSG_09791
PTSG_11682
DDI:
DDB_G0276153
(nsfA)
DPP:
DICPUDRAFT_46059
DFA:
DFA_03785
DFA_03786
(nsfA)
EHI:
EHI_004640
(8.t00066)
EDI:
EDI_144580
EIV:
EIN_176430
ACAN:
ACA1_251570
PFA:
PF3D7_0303000
PFD:
PFDG_02346
PFH:
PFHG_02382
PYO:
PY17X_0403800
PCB:
PCHAS_040250
(PC000247.00.0)
PBE:
PBANKA_0401600
PKN:
PKH_083720
PVX:
PVX_119275
PCY:
PCYB_084620
TAN:
TA11700
TPV:
TP02_0172
TOT:
TOT_020000158
BEQ:
BEWA_018910
BBO:
BBOV_II007200
(18.m06598)
BMIC:
BMR1_01G03495
CPV:
cgd2_3010
CHO:
Chro.20314
TGO:
TGME49_318510
TET:
TTHERM_00039210
PTM:
GSPATT00006065001
GSPATT00010950001
GSPATT00014432001
SMIN:
v1.2.040399.t1
(symbB.v1.2.040399.t1)
PTI:
PHATRDRAFT_12620
PHATR_13383
FCY:
FRACYDRAFT_156624
FRACYDRAFT_184938
FRACYDRAFT_185338
FRACYDRAFT_264906
(ACK1)
TPS:
THAPSDRAFT_11221
THAPSDRAFT_3575
NGD:
NGA_0429800
NGA_0430301
(NSF)
AAF:
AURANDRAFT_53460
PIF:
PITG_08600
PSOJ:
PHYSODRAFT_488608
SPAR:
SPRG_09631
SPRG_21859
EHX:
EMIHUDRAFT_100162
EMIHUDRAFT_219473
EMIHUDRAFT_452918
EMIHUDRAFT_456468
GTT:
GUITHDRAFT_148248
(NSFA)
GUITHDRAFT_84263
(NSFB)
TBR:
TB927.1.1560
TBG:
TbgDal_I790
TCR:
506477.20
508995.40
LMA:
LMJF_20_0810
LIF:
LINJ_20_0820
LDO:
LDBPK_200820
LMI:
LMXM_20_0810
LBZ:
LBRM_20_4990
LPAN:
LPMP_204990
NGR:
NAEGRDRAFT_34168
NAEGRDRAFT_59102
TVA:
TVAG_476020
PCA:
Pcar_0681
MTA:
Moth_1077
MTHO:
MOTHE_c10370
(ftsH2)
MTHZ:
MOTHA_c11260
(ftsH4)
WCH:
wcw_0613
(nsfA)
» show all
Taxonomy
Reference
1 [PMID:
7646486
]
Authors
Confalonieri F, Duguet M.
Title
A 200-amino acid ATPase module in search of a basic function.
Journal
Bioessays 17:639-50 (1995)
DOI:
10.1002/bies.950170710
Reference
2 [PMID:
9817926
]
Authors
Imamura A, Tamura S, Shimozawa N, Suzuki Y, Zhang Z, Tsukamoto T, Orii T, Kondo N, Osumi T, Fujiki Y.
Title
Temperature-sensitive mutation in PEX1 moderates the phenotypes of peroxisome deficiency disorders.
Journal
Hum Mol Genet 7:2089-94 (1998)
DOI:
10.1093/hmg/7.13.2089
Reference
3 [PMID:
9606181
]
Authors
Babst M, Wendland B, Estepa EJ, Emr SD.
Title
The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function.
Journal
EMBO J 17:2982-93 (1998)
DOI:
10.1093/emboj/17.11.2982
Other DBs
ExplorEnz - The Enzyme Database:
3.6.4.6
IUBMB Enzyme Nomenclature:
3.6.4.6
ExPASy - ENZYME nomenclature database:
3.6.4.6
BRENDA, the Enzyme Database:
3.6.4.6
LinkDB
All DBs
DBGET
integrated database retrieval system