| Entry |
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| Name |
fumarylacetoacetase;
beta-diketonase;
fumarylacetoacetate hydrolase
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| Class |
Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances
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| Sysname |
4-fumarylacetoacetate fumarylhydrolase
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| Reaction(IUBMB) |
4-fumarylacetoacetate + H2O = acetoacetate + fumarate [RN: R01364]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Also acts on other 3,5- and 2,4-dioxo acids.
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| History |
EC 3.7.1.2 created 1961
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| Pathway |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K16171 | fumarylacetoacetate (FAA) hydrolase |
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| Genes |
» show all
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| Reference |
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| Authors |
CONNORS WM, STOTZ E |
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| Title |
The purification and properties of a triacetic acid-hydrolyzing enzyme. |
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| Journal |
J Biol Chem 178:881-90 (1949) |
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| Reference |
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| Authors |
EDWARDS SW, KNOX WE. |
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| Title |
Homogentisate metabolism: the isomerization of maleylacetoacetate by an enzyme which requires glutathione. |
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| Journal |
J Biol Chem 220:79-91 (1956) |
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| Reference |
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| Authors |
MEISTER A, GREENSTEIN JP |
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| Title |
Enzymatic hydrolysis of 2,4-diketo acids. |
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| Journal |
J Biol Chem 175:573-88 (1948) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.7.1.2 |
| ExPASy - ENZYME nomenclature database: | 3.7.1.2 |
| UM-BBD (Biocatalysis/Biodegradation Database): | 3.7.1.2 |
| BRENDA, the Enzyme Database: | 3.7.1.2 |
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| LinkDB |
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