KEGG   ENZYME: 3.7.1.23Help
Entry
EC 3.7.1.23                 Enzyme                                 

Name
maleylpyruvate hydrolase;
hbzF (gene name)
Class
Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances
BRITE hierarchy
Sysname
(2Z)-4,6-dioxohept-2-enedioate acylhydrolase
Reaction(IUBMB)
3-maleylpyruvate + H2O = maleate + pyruvate [RN:R11257]
Reaction(KEGG)
Substrate
3-maleylpyruvate [CPD:C02167];
H2O [CPD:C00001]
Product
maleate [CPD:C01384];
pyruvate [CPD:C00022]
Comment
The enzyme, characterized from the bacterium Pseudomonas alcaligenes NCIMB 9867, catalyses the hydrolysis of 3-maleylpyruvate, the ring-cleavage product of gentisate. The enzyme can also act on a number of maleylpyruvate derivatives, such as (2E)-2-methyl-4,6-dioxohept-2-enedioate and (2E)-3-methyl-4,6-dioxohept-2-enedioate. Activated by Mn2+. May be identical to EC 3.7.1.5, acylpyruvate hydrolase.
History
EC 3.7.1.23 created 2016
Pathway
ec00350  Tyrosine metabolism
ec01100  Metabolic pathways
Orthology
K20758  maleylpyruvate hydrolase
Reference
1  [PMID:5124802]
  Authors
Hopper DJ, Chapman PJ, Dagley S
  Title
The enzymic degradation of alkyl-substituted gentisates, maleates and malates.
  Journal
Biochem J 122:29-40 (1971)
DOI:10.1042/bj1220029
Reference
2  [PMID:7400101]
  Authors
Bayly RC, Chapman PJ, Dagley S, Di Berardino D
  Title
Purification and some properties of maleylpyruvate hydrolase and fumarylpyruvate  hydrolase from Pseudomonas alcaligenes.
  Journal
J Bacteriol 143:70-7 (1980)
DOI:10.1128/JB.143.1.70-77.1980
Reference
3  [PMID:23204427]
  Authors
Liu K, Liu TT, Zhou NY
  Title
HbzF catalyzes direct hydrolysis of maleylpyruvate in the gentisate pathway of Pseudomonas alcaligenes NCIMB 9867.
  Journal
Appl Environ Microbiol 79:1044-7 (2013)
DOI:10.1128/AEM.02931-12
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.7.1.23
IUBMB Enzyme Nomenclature: 3.7.1.23
ExPASy - ENZYME nomenclature database: 3.7.1.23
BRENDA, the Enzyme Database: 3.7.1.23
LinkDB All DBs

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