KEGG   ENZYME: 3.7.1.9Help
Entry
EC 3.7.1.9                  Enzyme                                 

Name
2-hydroxymuconate-6-semialdehyde hydrolase;
2-hydroxy-6-oxohepta-2,4-dienoate hydrolase;
2-hydroxymuconic semialdehyde hydrolase;
HMSH;
HOD hydrolase;
xylF (gene name);
2-hydroxymuconate-semialdehyde formylhydrolase;
2-hydroxymuconate-semialdehyde hydrolase
Class
Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances
BRITE hierarchy
Sysname
2-hydroxymuconate-6-semialdehyde formylhydrolase
Reaction(IUBMB)
2-hydroxymuconate-6-semialdehyde + H2O = formate + 2-oxopent-4-enoate [RN:R02604]
Reaction(KEGG)
Substrate
2-hydroxymuconate-6-semialdehyde [CPD:C00682];
H2O [CPD:C00001]
Product
formate [CPD:C00058];
2-oxopent-4-enoate [CPD:C00596]
Comment
The enzyme is involved in the degradation of catechols.
History
EC 3.7.1.9 created 1990, modified 2013
Pathway
ec00362  Benzoate degradation
ec00622  Xylene degradation
ec00643  Styrene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K10216  2-hydroxymuconate-semialdehyde hydrolase
Genes
RTG: NCTC13098_00853(xylF_2)
PSD: DSC_09175
RBD: ALSL_0879
PPSE: BN5_3615(nahN)
PPI: ND087(nahN)
PPJ: RK21_04238
PSC: A458_06525
PSTU: UIB01_22735
PBM: CL52_14705
PFK: PFAS1_28780
PAT: Patl_0074
PPHE: PP2015_462
PAGA: PAGA_a1999
MAD: HP15_1112(dmpD) HP15_4033(xylF)
AEH: Mlg_2456
HCH: HCH_03715
APAC: S7S_13285
TBN: TBH_C0921
RPI: Rpic_4621
RME: Rmet_1306
BCEN: DM39_4829(xylF)
BCT: GEM_5398
BCED: DM42_4988(xylF)
BCON: NL30_24575
BTEI: WS51_00585
BPSL: WS57_12140
BPAR: BN117_2519
BPA: BPP3695
BBR: BB4129
AJS: Ajs_0221
VEI: Veis_2786
HPSE: HPF_01875(xylF1)
MPT: Mpe_A2274
LCH: Lcho_3344
AZO: azo1968(xylF)
AOA: dqs_2123
ARC: ABLL_2439
MTUN: MTUNDRAET4_3903(dmpD)
SMAZ: LH19_27440
SGI: SGRAN_2799(thnD)
HTL: HPTL_0051
SAY: TPY_0645(mhpC)
MIA: OCU_07410
MID: MIP_01280
MYO: OEM_07480
MIR: OCQ_07550
MMM: W7S_03620
MHAS: MHAS_04027(xylF)
CAMG: CAMM_02590
RRT: 4535765_04589(xylF_2)
SMAL: SMALA_1217
NML: Namu_4111
AMQ: AMETH_2411(mhpC)
PDX: Psed_6034
PSEE: FRP1_12950
PAUT: Pdca_36310
ACTI: UA75_15785
ACAD: UA74_15225
CAU: Caur_1353
TRO: trd_1390
TTJ: TTHB237
 » show all
Taxonomy
Reference
1  [PMID:4325686]
  Authors
Sala-Trepat JM, Evans WC.
  Title
The meta cleavage of catechol by Azotobacter species. 4-Oxalocrotonate pathway.
  Journal
Eur J Biochem 20:400-13 (1971)
DOI:10.1111/j.1432-1033.1971.tb01406.x
Reference
2  [PMID:3481421]
  Authors
Harayama S, Rekik M, Wasserfallen A, Bairoch A.
  Title
Evolutionary relationships between catabolic pathways for aromatics: conservation of gene order and nucleotide sequences of catechol oxidation genes of pWW0 and NAH7 plasmids.
  Journal
Mol Gen Genet 210:241-7 (1987)
DOI:10.1007/bf00325689
Reference
3  [PMID:7890778]
  Authors
Diaz E, Timmis KN
  Title
Identification of functional residues in a 2-hydroxymuconic semialdehyde hydrolase. A new member of the alpha/beta hydrolase-fold family of enzymes which  cleaves carbon-carbon bonds.
  Journal
J Biol Chem 270:6403-411 (1995)
DOI:10.1074/jbc.270.11.6403
Other DBs
ExplorEnz - The Enzyme Database: 3.7.1.9
IUBMB Enzyme Nomenclature: 3.7.1.9
ExPASy - ENZYME nomenclature database: 3.7.1.9
UM-BBD (Biocatalysis/Biodegradation Database): 3.7.1.9
BRENDA, the Enzyme Database: 3.7.1.9
CAS: 54004-61-4
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