| Entry |
|
|---|
| Name |
aromatic-L-amino-acid decarboxylase;
DOPA decarboxylase;
tryptophan decarboxylase;
hydroxytryptophan decarboxylase;
L-DOPA decarboxylase;
aromatic amino acid decarboxylase;
5-hydroxytryptophan decarboxylase;
aromatic-L-amino-acid carboxy-lyase (tryptamine-forming)
|
|---|
| Class |
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
|
|---|
| Sysname |
aromatic-L-amino-acid carboxy-lyase
|
|---|
| Reaction(IUBMB) |
(1) L-dopa = dopamine + CO2 [RN: R02080];
(2) 5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2 [RN: R02701]
|
|---|
| Reaction(KEGG) |
|
|---|
| Substrate |
|
|---|
| Product |
|
|---|
| Comment |
A pyridoxal-phosphate protein. The enzyme also acts on some other aromatic L-amino acids, including L-tryptophan, L-tyrosine and L-phenylalanine.
|
|---|
| History |
EC 4.1.1.28 created 1961 (EC 4.1.1.26 and EC 4.1.1.27 both created 1961 and incorporated 1972)
|
|---|
| Pathway |
| ec00950 | Isoquinoline alkaloid biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
|
|---|
| Orthology |
| K01593 | aromatic-L-amino-acid/L-tryptophan decarboxylase |
|
|---|
| Genes |
» show all
|
|---|
| Reference |
|
|---|
| Authors |
Christenson JG, Dairman W, Udenfriend S. |
|---|
| Title |
On the identity of DOPA decarboxylase and 5-hydroxytryptophan decarboxylase (immunological titration-aromatic L-amino acid decarboxylase-serotonin-dopamine-norepinephrine). |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
LOVENBERG W, WEISSBACH H, UDENFRIEND S. |
|---|
| Title |
Aromatic L-amino acid decarboxylase. |
|---|
| Journal |
J Biol Chem 237:89-93 (1962) |
|---|
| Reference |
|
|---|
| Authors |
McGILVERY RW, COHEN PP |
|---|
| Title |
The decarboxylation of L-phenylalanine by Streptococcus faecalis R. |
|---|
| Journal |
J Biol Chem 174:813-6 (1948) |
|---|
| Reference |
|
|---|
| Authors |
SEKERIS CE |
|---|
| Title |
[ON TYROSINE METABOLISM IN INSECTS. XII. PURIFICATION, PROPERTIES AND SUBSTRATE SPECIFICITY OF DOPA-DECARBOXYLASE]. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
WEISSBACH H, BOGDANSKI DF, REDFIELD BG, UDENFRIEND S. |
|---|
| Title |
Studies on the effect of vitamin B6 on 5-hydroxytryptamine (serotonin) formation. |
|---|
| Journal |
J Biol Chem 227:617-24 (1957) |
|---|
| Other DBs |
| ExplorEnz - The Enzyme Database: | 4.1.1.28 |
| ExPASy - ENZYME nomenclature database: | 4.1.1.28 |
|
|---|
| LinkDB |
|
|---|
