Entry |
|
Name |
aromatic-L-amino-acid decarboxylase;
DOPA decarboxylase;
tryptophan decarboxylase;
hydroxytryptophan decarboxylase;
L-DOPA decarboxylase;
aromatic amino acid decarboxylase;
5-hydroxytryptophan decarboxylase;
aromatic-L-amino-acid carboxy-lyase (tryptamine-forming)
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Class |
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
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Sysname |
aromatic-L-amino-acid carboxy-lyase
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Reaction(IUBMB) |
(1) L-dopa = dopamine + CO2 [RN: R02080];
(2) 5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2 [RN: R02701]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
A pyridoxal-phosphate protein. The enzyme also acts on some other aromatic L-amino acids, including L-tryptophan, L-tyrosine and L-phenylalanine.
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History |
EC 4.1.1.28 created 1961 (EC 4.1.1.26 and EC 4.1.1.27 both created 1961 and incorporated 1972)
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Pathway |
ec00950 | Isoquinoline alkaloid biosynthesis |
ec01110 | Biosynthesis of secondary metabolites |
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Orthology |
K01593 | aromatic-L-amino-acid/L-tryptophan decarboxylase |
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Genes |
» show all
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Reference |
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Authors |
Christenson JG, Dairman W, Udenfriend S. |
Title |
On the identity of DOPA decarboxylase and 5-hydroxytryptophan decarboxylase (immunological titration-aromatic L-amino acid decarboxylase-serotonin-dopamine-norepinephrine). |
Journal |
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Reference |
|
Authors |
LOVENBERG W, WEISSBACH H, UDENFRIEND S. |
Title |
Aromatic L-amino acid decarboxylase. |
Journal |
J Biol Chem 237:89-93 (1962) |
Reference |
|
Authors |
McGILVERY RW, COHEN PP |
Title |
The decarboxylation of L-phenylalanine by Streptococcus faecalis R. |
Journal |
J Biol Chem 174:813-6 (1948) |
Reference |
|
Authors |
SEKERIS CE |
Title |
[ON TYROSINE METABOLISM IN INSECTS. XII. PURIFICATION, PROPERTIES AND SUBSTRATE SPECIFICITY OF DOPA-DECARBOXYLASE]. |
Journal |
Hoppe Seylers Z Physiol Chem 332:70-8 (1963) |
Reference |
|
Authors |
WEISSBACH H, BOGDANSKI DF, REDFIELD BG, UDENFRIEND S. |
Title |
Studies on the effect of vitamin B6 on 5-hydroxytryptamine (serotonin) formation. |
Journal |
J Biol Chem 227:617-24 (1957) |
Other DBs |
ExplorEnz - The Enzyme Database: | 4.1.1.28 |
ExPASy - ENZYME nomenclature database: | 4.1.1.28 |
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LinkDB |
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