KEGG   ENZYME: 4.1.1.99
Entry
EC 4.1.1.99                 Enzyme                                 

Name
phosphomevalonate decarboxylase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
ATP:(R)-5-phosphomevalonate carboxy-lyase (adding ATP; isopentenyl-phosphate-forming)
Reaction(IUBMB)
ATP + (R)-5-phosphomevalonate = ADP + phosphate + isopentenyl phosphate + CO2 [RN:R10561]
Reaction(KEGG)
R10561
Substrate
ATP [CPD:C00002];
(R)-5-phosphomevalonate [CPD:C01107]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
isopentenyl phosphate [CPD:C20345];
CO2 [CPD:C00011]
Comment
The enzyme participates in a mevalonate pathway that occurs in halophilic archaea. The activity is also present in eubacteria of the Chloroflexi phylum. cf. EC 4.1.1.33, diphosphomevalonate decarboxylase, and EC 4.1.1.110, bisphosphomevalonate decarboxylase.
History
EC 4.1.1.99 created 2014, modified 2018
Pathway
ec00900  Terpenoid backbone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K17942  phosphomevalonate decarboxylase
Genes
RRS: RoseRS_4285
RCA: Rcas_0936
HAL: VNG_0593G(dmd)
HSL: OE_1893F(mvaD)
HDL: HALDL1_07090
HHB: Hhub_1732(mvaD)
HJE: HacjB3_11155
HALH: HTSR_1043(mvaD) HTSR_1765
HHSR: HSR6_1076(mvaD) HSR6_1831(pmd)
HSU: HLASF_0833(mvaD)
HSF: HLASA_0830(mvaD)
HMA: rrnAC1489(dmd)
HHI: HAH_2062(dmd)
NPH: NP_1580A(mvaD)
NMO: Nmlp_1993(mvaD)
HUT: Huta_0691
HTI: HTIA_0600
HALA: Hrd1104_09580(mvaD)
HMU: Hmuk_2128
HALL: LC1Hm_1696(dmd)
HRR: HZS55_09955(mvaD)
HWA: HQ_1525A(mvaD)
HWC: Hqrw_1624(mvaD)
HVO: HVO_1412(mvaD)
HME: HFX_1486(dmd)
HALM: FCF25_13955(mvaD)
HLA: Hlac_1434
HALN: B4589_002050(mvaD)
HDF: AArcSl_0776(mvaD)
HTU: Htur_1087
NMG: Nmag_3235(mvaD)
NAT: NJ7G_3246
SALI: L593_12340
NBG: DV706_01870(mvaD)
NAS: GCU68_11880(mvaD)
 » show all
Reference
1  [PMID:24327557]
  Authors
Dellas N, Thomas ST, Manning G, Noel JP
  Title
Discovery of a metabolic alternative to the classical mevalonate pathway.
  Journal
Elife 2:e00672 (2013)
DOI:10.7554/eLife.00672
Reference
2  [PMID:24375100]
  Authors
Vannice JC, Skaff DA, Keightley A, Addo J, Wyckoff GJ, Miziorko HM.
  Title
Identification in Haloferax volcanii of Phosphomevalonate Decarboxylase and Isopentenyl Phosphate Kinase as Catalysts of the Terminal Enzymatic Reactions in  an Archaeal Alternate Mevalonate Pathway.
  Journal
J Bacteriol (2013)
DOI:10.1128/JB.01230-13
  Sequence
[hvo:HVO_1412]
Reference
3  [PMID:31268677]
  Authors
Thomas ST, Louie GV, Lubin JW, Lundblad V, Noel JP
  Title
Substrate Specificity and Engineering of Mevalonate 5-Phosphate Decarboxylase.
  Journal
ACS Chem Biol 14:1767-1779 (2019)
DOI:10.1021/acschembio.9b00322
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.99
IUBMB Enzyme Nomenclature: 4.1.1.99
ExPASy - ENZYME nomenclature database: 4.1.1.99
BRENDA, the Enzyme Database: 4.1.1.99
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